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PHG0007

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C Arimany-Nardi et al.
British journal of pharmacology, 171(16), 3868-3880 (2014-05-02)
Inhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across the plasma membrane. The aim of this study was to identify transporter proteins...
Junghui Koo et al.
The Journal of biological chemistry, 290(22), 14120-14129 (2015-04-22)
Rictor, an essential component of mTOR complex 2 (mTORC2), plays a pivotal role in regulating mTOR signaling and other biological functions. Posttranslational regulation of rictor (e.g. via degradation) and its underlying mechanism are largely undefined and thus are the focus...
Karolin Zerulla et al.
PloS one, 9(4), e94819-e94819 (2014-04-16)
Haloferax volcanii uses extracellular DNA as a source for carbon, nitrogen, and phosphorous. However, it can also grow to a limited extend in the absence of added phosphorous, indicating that it contains an intracellular phosphate storage molecule. As Hfx. volcanii...
Marta Luna-Sánchez et al.
EMBO molecular medicine, 7(5), 670-687 (2015-03-25)
Primary coenzyme Q10 (CoQ10) deficiency is due to mutations in genes involved in CoQ biosynthesis. The disease has been associated with five major phenotypes, but a genotype-phenotype correlation is unclear. Here, we compare two mouse models with a genetic modification...
Frédéric Lamoth et al.
Journal of clinical microbiology, 53(10), 3176-3181 (2015-07-24)
Invasive mold infections are life-threatening diseases for which appropriate antifungal therapy is crucial. Their epidemiology is evolving, with the emergence of triazole-resistant Aspergillus spp. and multidrug-resistant non-Aspergillus molds. Despite the lack of interpretive criteria, antifungal susceptibility testing of molds may...
Arturo Luna-Tapia et al.
Antimicrobial agents and chemotherapy, 59(4), 2410-2420 (2015-02-11)
The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of "toxic" sterol intermediates are both thought to compromise plasma membrane function. However, the effects of ergosterol depletion upon the...
Chloe Kim et al.
Nanoscale, 7(42), 17820-17826 (2015-10-13)
Current diagnostic methods for traumatic brain injury (TBI), which accounts for 15% of all emergency room visits, are limited to neuroimaging modalities. The challenges of accurate diagnosis and monitoring of TBI have created the need for a simple and sensitive...
Dominique E Williams et al.
Chembiochem : a European journal of chemical biology, 16(10), 1474-1482 (2015-05-09)
With the goal of designing a lysosomal phospholipase mimic, we optimized experimental variables to enhance Ce(IV) -assisted hydrolysis of phosphatidylcholine (PC) liposomes. Our best result was obtained with the chelating agent bis-tris propane (BTP). Similar to the hydrolytic enzyme, Ce(IV)...
Seyed-Fakhreddin Torabi et al.
Journal of molecular evolution, 81(5-6), 225-234 (2015-11-19)
We report an investigation of the functional relationship between two independently selected RNA-cleaving DNAzymes, NaA43, and Ce13, through in vitro selection. The NaA43 DNAzyme was obtained through a combination of gel-based and column-based in vitro selection in the presence of...
Tania L Gonzalez et al.
Nucleic acids research, 43(14), 7152-7161 (2015-07-04)
Effector-triggered immunity (ETI) is activated when plant disease resistance (R) proteins recognize the presence of pathogen effector proteins delivered into host cells. The ETI response generally encompasses a defensive 'hypersensitive response' (HR) that involves programmed cell death at the site...
Shota Tanaka et al.
Biological & pharmaceutical bulletin, 38(3), 435-440 (2015-03-12)
Epithelial-mesenchymal transition (EMT) and changes in the expression of the microRNA-200 (miR-200) family were examined in the human colorectal cancer (CRC) cell line SW620 with acquired oxaliplatin (L-OHP) resistance. Two CRC cell lines, SW480, derived from primary CRC, and SW620...
Shunsuke Izaki et al.
Journal of pharmaceutical sciences, 104(6), 1929-1937 (2015-03-27)
Development of high-concentration antibody formulations for subcutaneous administration remains challenging. Recently, a precipitation-redissolution method was proposed to prepare suspensions or precipitates of salt-dissociable protein-poly(amino acid) complexes. To elucidate the utility of this method for protein therapy, we investigated the feasibility...
Rajendra Prasad et al.
Nucleic acids research, 42(10), 6337-6351 (2014-04-29)
Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme NAD(+) and plays multifaceted roles in cellular responses to genotoxic stress, including DNA repair. It had been shown that mouse...
Jiping Zhao et al.
Inflammation, 38(4), 1464-1472 (2015-02-07)
The aim of our study was to elucidate the function and signaling pathway of found in inflammatory zone 1 (FIZZ1) in airway remodeling in asthma. We used a mice model sensitized and challenged by ovalbumin (OVA) to evaluate the expression...
Ryan D Beveridge et al.
Cell cycle (Georgetown, Tex.), 13(21), 3450-3459 (2014-12-09)
We previously identified and characterized TELO2 as a human protein that facilitates efficient DNA damage response (DDR) signaling. A subsequent yeast 2-hybrid screen identified LARG; Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (also known as Arhgef12), as a potential novel TELO2...
Ryan J Lopez et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 78-87 (2015-05-27)
Pyrroloquinoline quinone dependent soluble glucose dehydrogenase (PQQ-sGDH) enzymatic MWCNT electrodes were p roduced using 1-pyrenecarboxylic acid (PCA) activated through carbodiimide functionalization and 1-Pyrenebutyric acid N-hydroxysuccinimide ester (PBSE) as tethering agents. At 600 mV potential, the current density generated by the...
Tanya L Johnson et al.
Journal of bacteriology, 196(24), 4245-4252 (2014-10-01)
Gram-negative bacteria have evolved several highly dedicated pathways for extracellular protein secretion, including the type II secretion (T2S) system. Since substrates secreted via the T2S system include both virulence factors and degradative enzymes, this secretion system is considered a major...
Kailash P Patra et al.
Infection and immunity, 83(5), 1799-1808 (2015-02-19)
A vaccine to prevent the transmission of malaria parasites from infected humans to mosquitoes is an important component for the elimination of malaria in the 21st century, yet it remains neglected as a priority of malaria vaccine development. The lead...
Tomoaki Harada et al.
Physical chemistry chemical physics : PCCP, 16(28), 14947-14952 (2014-06-17)
Luminescent europium (Eu) and dysprosium (Dy) doped yttrium-vanadate (Y-V) nanoparticles (NPs) were synthesized in the cavity of the protein, apoferritin. Y-V NPs were synthesized by incubating a solution of apoferritin with Y(3+) and VO3(-) ions in the presence of ethylene...
Tara L Croston et al.
American journal of physiology. Heart and circulatory physiology, 307(1), H54-H65 (2014-04-30)
The mitochondrion has been implicated in the development of diabetic cardiomyopathy. Examination of cardiac mitochondria is complicated by the existence of spatially distinct subpopulations including subsarcolemmal (SSM) and interfibrillar (IFM). Dysfunction to cardiac SSM has been reported in murine models...
Nan Zhang et al.
BMC genomics, 16, 685-685 (2015-09-09)
Bacillus amyloliquefaciens SQR9 is a plant growth-promoting rhizobacteria (PGPR) with outstanding abilities to enhance plant growth and to control soil-borne diseases. Root exudates is known to play important roles in plant-microbe interactions. To explore the rhizosphere interactions and plant-beneficial characteristics...
Patricia L Bustos et al.
Parasitology, 142(8), 1024-1032 (2015-04-01)
Cyclosporin A (CsA) specifically inhibits the mitochondrial permeability transition pore (mPTP). Opening of the mPTP, which is triggered by high levels of matrix [Ca2+] and/or oxidative stress, leads to mitochondrial dysfunction and thus to cell death by either apoptosis or...
Seock Hwan Choi et al.
Journal of biomedical materials research. Part A, 103(4), 1391-1403 (2014-07-22)
Acellular scaffolds, possessing an intact three-dimensional extracellular matrix (ECM) architecture and biochemical components, are promising for regeneration of complex organs, such as the kidney. We have successfully developed a porcine renal acellular scaffold and analyzed its physical/biochemical characteristics, biocompatibility, and...
Mrinalini Balki et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 61(9), 808-818 (2014-06-08)
To compare the in vitro contractile responses to oxytocin, ergonovine, prostaglandin F2 alpha (PGF2α), and misoprostol in isolated myometrium from non-labouring and labouring pregnant women. Myometrial strips obtained from labouring (with or without oxytocin augmentation) and non-labouring women undergoing Cesarean...
P Massoner et al.
British journal of cancer, 111(5), 955-964 (2014-07-06)
Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an...
Hikmet Nural-Guvener et al.
International journal of molecular sciences, 16(5), 11482-11499 (2015-05-23)
Recent studies have linked histone deacetylases (HDAC) to remodeling of the heart and cardiac fibrosis in heart failure. However, the molecular mechanisms linking chromatin remodeling events with observed anti-fibrotic effects are unknown. Here, we investigated the molecular players involved in...
Cheng Guo Li et al.
Lab on a chip, 15(16), 3286-3292 (2015-07-21)
The development of real-time innocuous blood diagnosis has been a long-standing goal in healthcare; an improved, miniature, all-in-one point-of-care testing (POCT) system with low cost and simplified operation is highly desired. Here, we present a one-touch-activated blood multidiagnostic system (OBMS)...
Brian R Fritz et al.
Nucleic acids research, 42(10), 6774-6785 (2014-05-06)
In vitro ribosome construction could enable studies of ribosome assembly and function, provide a route toward constructing minimal cells for synthetic biology, and permit the construction of ribosome variants with new functions. Toward these long-term goals, we recently reported on...
Yi-Chun Chen et al.
BMC infectious diseases, 15, 277-277 (2015-07-22)
This study aimed to investigate the rate of fluconazole-non-susceptible Cryptococcus neoformans in Southern Taiwan for the period 2001-2012 and analyze the risk factors for acquiring it among patients with invasive cryptococcosis. All enrolled strains were isolated from blood or cerebrospinal...
Karol Szczepanek et al.
Basic research in cardiology, 110(6), 53-53 (2015-09-12)
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that contributes a crucial role in protection against ischemia (ISC)-reperfusion (REP) injury by driving expression of anti-apoptotic and anti-oxidant genes. STAT3 is also present in the mitochondria, where...
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