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Vincent O Oninla et al.
Journal of lipid research, 55(12), 2606-2619 (2014-10-24)
During endocytosis, membrane components move to intraluminal vesicles of the endolysosomal compartment for digestion. At the late endosomes, cholesterol is sorted out mainly by two sterol-binding proteins, Niemann-Pick protein type C (NPC)1 and NPC2. To study the NPC2-mediated intervesicular cholesterol
Yunxia Lu et al.
Life sciences, 92(24-26), 1165-1173 (2013-05-18)
Obesity is associated with hypertriglyceridemia and elevated circulating free fatty acids (FFA), resulting in endothelial dysfunction. Endoplasmic reticulum (ER) stress has been implicated in many of these processes. To determine if ER stress participates in palmitate-induced apoptosis, we investigated the
Soo Jin Yang et al.
PloS one, 9(8), e105456-e105456 (2014-08-19)
Sirtuin (Sirt), a sensor of the cell metabolic state, regulates glucose and lipid metabolism. The aim of this study was to address whether rosiglitazone (RGZ) alters hepatic Sirt1 and whether Sirt1 and/or Sirt6 have a regulatory role in the protective
Sabeera Bonala et al.
Molecular endocrinology (Baltimore, Md.), 27(9), 1518-1535 (2013-08-10)
Obesity is associated with insulin resistance and abnormal peripheral tissue glucose uptake. However, the mechanisms that interfere with insulin signaling and glucose uptake in human skeletal muscle during obesity are not fully characterized. Using microarray, we have identified that the
Y Min et al.
Diabetologia, 47(1), 75-81 (2003-11-25)
Gestational diabetes is a metabolic disorder affecting 2-5% of women and is a predictor of obesity, Type 2 diabetes mellitus and cardiovascular disease. Insulin resistance, a characteristic of gestational diabetes and obesity, is correlated with the fatty acids profile of
Junfei Jin et al.
American journal of physiology. Endocrinology and metabolism, 305(7), E853-E867 (2013-08-08)
Periodontal disease is more prevalent and severe in patients with diabetes than in nondiabetic patients. In addition to diabetes, a large number of studies have demonstrated an association between obesity and chronic periodontal disease. However, the underlying mechanisms have not
Yaping Zhang et al.
Clinica chimica acta; international journal of clinical chemistry, 437, 31-37 (2014-07-13)
Changes in the levels of lipids are associated with breast cancer (BC). Disease-specific serum free fatty acids (FFAs) were quantified using chip-based direct-infusion nanoelectrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (CBDInanoESI-FTICR MS) in the negative ion mode. Multiple point
Megumi Ishii et al.
Archives of biochemistry and biophysics, 566, 26-35 (2014-12-21)
Obesity-associated insulin resistance is a major pathogenesis of type 2 diabetes mellitus and is characterized by defects in insulin signaling. High concentrations of plasma free fatty acids (FFAs) are involved in the etiology of obesity-associated insulin resistance. However, the detailed
Dong-il Kim et al.
Diabetes, 64(1), 60-71 (2014-09-05)
Arginine methylation is responsible for diverse biological functions and is mediated by protein arginine methyltransferases (PRMTs). Nonalcoholic fatty liver disease (NAFLD) is accompanied by excessive hepatic lipogenesis via liver X receptor α (LXRα). Thus we examined the pathophysiological role of
Christian Zorzetto et al.
Fitoterapia, 100, 95-109 (2014-12-03)
In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Islands where they are traditionally used as diuretic, wound healing, vermifuge, sedative and
V N Titov et al.
Klinicheskaia meditsina, 91(1), 20-27 (2013-05-11)
LDLP and VLDLP have different biological functions: phylogenetically older LDLP transfer FA that serve as substrates for intracellular production of energy and ATP while VLDLP transfer FA--precursors of cell membranes and eicosanoids. The cells absorb LDLP via apoB-100 endocytosis and
Shuang-Xi Li et al.
Cancer, 120(10), 1520-1531 (2014-05-28)
The functions of cytoskeleton-associated membrane protein 4 (CKAP4), one kind of type II transmembrane protein, are associated with the palmitoyl acyltransferase DHHC2. The objective of the current study was to investigate CKAP4/DHHC2 expression and its prognostic significance in patients with
Lam N Nguyen et al.
Journal of virology, 88(21), 12311-12325 (2014-08-15)
The hepatitis C virus (HCV) life cycle is tightly regulated by lipid metabolism of host cells. In order to identify host factors involved in HCV propagation, we have recently screened a small interfering RNA (siRNA) library targeting host genes that
M P Ip et al.
Clinical chemistry, 23(1), 35-40 (1977-01-01)
We describe a new and specific method for measurement of lecithin palmitic acid in amniotic fluid. Dipalmitoyl lecithin, the major alveolar surfactant, has previously been estimated by measuring the lecithin-sphingomyelin ratio, total lecithin, total phospholipid phosphorus, and (or) total palmitic
Tanit L Gabriel et al.
Diabetes, 63(10), 3310-3323 (2014-05-03)
In obesity, adipose tissue (AT) contains crown-like structures where macrophages surround nonviable adipocytes. To understand how AT macrophages (ATMs) contribute to development of insulin resistance, we examined their character in more detail. In silico analysis of F2 mouse populations revealed
Liang Dong et al.
The Journal of biological chemistry, 288(40), 28641-28655 (2013-08-21)
Prostaglandin endoperoxide H synthase-2 (PGHS-2), also known as cyclooxygenase-2 (COX-2), is a sequence homodimer. However, the enzyme exhibits half-site heme and inhibitor binding and functions as a conformational heterodimer having a catalytic subunit (Ecat) with heme bound and an allosteric
S B Han et al.
International journal of cosmetic science, 36(6), 588-597 (2014-09-16)
Quercetin, a phenolic compound isolated from plants, can act as an antioxidant to protect the skin from oxidative stress induced by ultraviolet rays. The aims of this work were (i) to compare the physical characterization of quercetin-loaded solid lipid nanoparticles
Uncoupling AMPK from autophagy: a foe that hinders the beneficial effects of metformin treatment on metabolic syndrome-associated atherosclerosis? Focus on "glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells".
Wen-Xing Ding
American journal of physiology. Cell physiology, 308(3), C246-C248 (2014-12-17)
F Guneral et al.
Clinical chemistry, 40(6), 862-866 (1994-06-01)
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days to 16 years, subdivided into five age groups. We quantified 69
Prakash Ramalingam et al.
Pharmaceutical research, 32(2), 389-402 (2014-08-02)
Solid lipid nanoparticles (SLNs) have been proposed as a colloidal carrier system that could enhance the oral bioavailability of curcumin. However, a burst release of the loaded drug, which occurs in acidic environments, has been a main obstacle to the
Yun-Ying Huang et al.
Apoptosis : an international journal on programmed cell death, 19(11), 1559-1570 (2014-09-15)
Palmitate, a common saturated free fatty acid (FFA), has been demonstrated to induce preadipocyte apoptosis in the absence of adipogenic stimuli, suggesting that preadipocytes may be prone to apoptosis under adipogenic insufficient conditions, like type 2 diabetes mellitus (T2DM). ClC-3
Masayuki Hatanaka et al.
Diabetes, 63(10), 3404-3415 (2014-05-20)
Saturated free fatty acids (FFAs) have complex effects on the islet β-cell, acutely promoting adaptive hyperplasia but chronically impairing insulin release. The acute effects of FFAs remain incompletely defined. To elucidate these early molecular events, we incubated mouse β-cells and
Meei-Hua Lin et al.
The Journal of investigative dermatology, 135(2), 462-470 (2014-09-04)
Fatty acid transport protein (FATP) 4 is one of a family of six FATPs that facilitate long- and very-long-chain fatty acid uptake. Mice lacking FATP4 are born with tight, thick skin and a defective barrier; they die neonatally because of
R P Mensink
Therapeutische Umschau. Revue therapeutique, 52(8), 509-514 (1995-08-01)
When various fats and oils are given to humans, marked differences in the concentrations of serum lipids and lipoproteins will be observed. Relative to dietary carbohydrates, lauric, myristic and palmitic acid, which are saturated fatty acids, but also trans fatty
Dong Chang et al.
Journal of the American College of Nutrition, 33(5), 406-411 (2014-08-01)
To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria.
Sharon M Louie et al.
Biochimica et biophysica acta, 1831(10), 1566-1572 (2013-07-23)
De novo lipogenesis is considered the primary source of fatty acids for lipid synthesis in cancer cells, even in the presence of exogenous fatty acids. Here, we have used an isotopic fatty acid labeling strategy coupled with metabolomic profiling platforms
Nolwenn Joffin et al.
Molecular nutrition & food research, 58(9), 1765-1775 (2014-06-11)
During aging, increased visceral adipose tissue (AT) mass may result in impaired metabolic status. A citrulline (CIT)-supplemented diet reduces AT mass in old rats. We hypothesized that CIT could directly affect fatty acid (FA) metabolism in retroperitoneal AT. A 24-h
Wenjie Ma et al.
The American journal of clinical nutrition, 101(1), 153-163 (2014-12-21)
Experimental evidence suggests that hepatic de novo lipogenesis (DNL) affects insulin homeostasis via synthesis of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). Few prospective studies have used fatty acid biomarkers to assess associations with type 2 diabetes. We
Microdetermination of long-chain fatty acids in plasma and tissues.
Dole P V and Meinertz H.
The Journal of Biological Chemistry, 235(9), 2595-2599 (1960)
Akira Kotani et al.
Journal of pharmaceutical and biomedical analysis, 97, 47-53 (2014-05-13)
The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) were also obtained to examine
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