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Sébastien M Labbé et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 2046-2058 (2015-02-15)
The present study was designed to investigate the effects of cold on brown adipose tissue (BAT) energy substrate utilization in vivo using the positron emission tomography tracers [(18)F]fluorodeoxyglucose (glucose uptake), 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid [nonesterified fatty acid (NEFA) uptake], and [(11)C]acetate (oxidative...
Liwei Dong et al.
International journal of molecular sciences, 16(7), 14655-14668 (2015-07-02)
Echinacoside is a natural compound with potent reactive oxygen species (ROS)-scavenging and anti-oxidative bioactivities, which protect cells from oxidative damages. As cancer cells are often under intense oxidative stress, we therefore tested if Echinacoside treatment would promote cancer development. Surprisingly...
Joseph P Salisbury et al.
BMC genomics, 16, 166-166 (2015-04-17)
The brown ghost knifefish (Apteronotus leptorhynchus) is a weakly electric teleost fish of particular interest as a versatile model system for a variety of research areas in neuroscience and biology. The comprehensive information available on the neurophysiology and neuroanatomy of...
Susanne Burdak-Rothkamm et al.
Cancer letters, 356(2 Pt B), 454-461 (2014-10-12)
Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct...
F Caiazza et al.
British journal of cancer, 112(12), 1895-1903 (2015-05-27)
Identification and validation of a targeted therapy for triple-negative breast cancer (TNBC), that is, breast cancers negative for oestrogen receptors, progesterone receptors and HER2 amplification, is currently one of the most urgent problems in breast cancer treatment. EGFR is one...
P G Morgan et al.
Mitochondrion, 20, 95-102 (2014-12-23)
Single-gene mutations that disrupt mitochondrial respiratory chain function in Caenorhabditis elegans change patterns of protein expression and metabolites. Our goal was to develop useful molecular fingerprints employing adaptable techniques to recognize mitochondrial defects in the electron transport chain. We analyzed...
Daniel P Morris et al.
PloS one, 10(8), e0134442-e0134442 (2015-08-06)
In mammals, increasing evidence supports mechanisms of co-transcriptional gene regulation and the generality of genetic control subsequent to RNA polymerase II (Pol II) recruitment. In this report, we use Pol II Chromatin Immunoprecipitation to investigate relationships between the mechanistic events...
Ashutosh Kumar et al.
Mutagenesis, 30(2), 237-245 (2014-11-09)
Zinc oxide (ZnO) nanoparticles are the mostly used engineered metal oxide nanoparticles in consumer products. This has increased the likelihood of human exposure to this engineered nanoparticle (ENPs) through different routes. At present, the majority of the studies concerning ZnO...
Junwen Zheng et al.
Journal of immunology research, 2015, 738547-738547 (2015-11-12)
Respiratory syncytial virus (RSV) infection upregulates genes of the suppressor of cytokine signaling (SOCS) family, which utilize a feedback loop to inhibit type I interferon dependent antiviral signaling pathway. Here, we reconstituted RSV nonstructural (NS) protein expression plasmids (pNS1, pNS2...
Pamela J Skinner et al.
PloS one, 10(7), e0131993-e0131993 (2015-07-03)
Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment. The pathology of these diseases involves the conversion of a protease sensitive...
Shuhei Suzuki et al.
Oncotarget, 6(1), 458-470 (2014-12-05)
Chemoresistance associated with cancer stem cells (CSCs), which is now being held responsible for the pervasive therapy resistance of pancreatic cancer, poses a major challenge to the successful management of this devastating malignancy. However, the molecular mechanism underlying the marked...
Y Fujikawa et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(7), 1010-1023 (2015-05-12)
Enteric glial cells (EGCs) play important roles in enteric integrity and regulation of gastrointestinal function. However, whether EGCs undergo pathophysiological changes in stress-associated gastrointestinal disorders is unknown. We investigated structural and functional alterations in colonic EGCs and their roles in...
Jagmohan Singh et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G292-G300 (2015-07-04)
Changes in oxidative stress may affect basal tone and relaxation of the internal anal sphincter (IAS) smooth muscle in aging. We examined this issue by investigating the effects of the oxidative stress inducer 6-anilino-5,8-quinolinedione (LY-83583) in basal as well as...
Daniel K C Chung et al.
Nature communications, 6, 7742-7742 (2015-07-25)
DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for repair. How targeting is achieved and the DNA repair pathways involved in this process remain unclear. Here, we show that the kinesin-14 motor protein complex (Cik1-Kar3) cooperates...
Philip A Kern et al.
The Journal of clinical endocrinology and metabolism, 99(12), E2772-E2779 (2014-10-10)
Although brown adipose tissue (BAT) activity is increased by a cold environment, little is known of the response of human white adipose tissue (WAT) to the cold. We examined both abdominal and thigh subcutaneous (SC) WAT from 71 subjects who...
Shirley Brenner et al.
The Journal of biological chemistry, 290(45), 27384-27392 (2015-09-24)
Adipogenesis is a complex process, accompanied by a chain of interdependent events. Disruption of key events in this cascade may interfere with the correct formation of adipose tissue. Polyamines were demonstrated necessary for adipogenesis; however, the underlying mechanism by which...
Bingxiang Wang et al.
Journal of molecular and cellular cardiology, 82, 22-32 (2015-03-05)
Calcium-activated chloride channels (CaCCs) have been implicated in hypertension; however, the mechanism underlying their involvement is unknown. The aim of this study was to determine whether the CaCC ANO1 is involved in the pathogenesis of spontaneous hypertension. Arterial ANO1 expression...
Chun-Yi Chiu et al.
Ultrasound in medicine & biology, 41(7), 1842-1852 (2015-04-30)
This study was performed to investigate osteoblastogenesis of human mesenchymal stem cells (hMSCs) cultured in 3-D scaffolds stimulated with low-intensity pulsed ultrasound and to identify the underlying mechanism mediated by soluble receptor activator of nuclear factor kappa B ligand (sRANKL)...
R Novaković et al.
Molecular human reproduction, 21(6), 545-551 (2015-03-10)
The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study...
Imelda Rosalyn Sianipar et al.
Microbiology and immunology, 59(8), 466-476 (2015-06-27)
Hepatitis C virus (HCV) NS5A protein plays crucial roles in viral RNA replication, virus assembly, and viral pathogenesis. Although NS5A has no known enzymatic activity, it modulates various cellular pathways through interaction with cellular proteins. HCV NS5A (and other HCV...
Yong Deok Lee et al.
The Journal of biological chemistry, 290(10), 6522-6530 (2015-01-07)
Lipid raft microdomains have important roles in various cellular responses. Caveolae are a specialized type of lipid rafts that are stabilized by oligomers of caveolin proteins. Here, we show that caveolin-1 (Cav-1) plays a crucial role in the regulation of...
Chin-Cheng Su
International journal of molecular medicine, 34(6), 1661-1668 (2014-10-02)
Tanshinone IIA (Tan-IIA) is extracted from Danshen (Salviae Miltiorrhizae Radix) and is a natural anti-cancer agent, which possesses antitumor activity in a variety of human cancer cells. Tan-IIA can induce apoptosis and inhibit the proliferation of gastric cancer through different...
Kristina S Burrack et al.
PLoS pathogens, 11(10), e1005191-e1005191 (2015-10-06)
Arthritogenic alphaviruses, including Ross River virus (RRV) and chikungunya virus (CHIKV), are responsible for explosive epidemics involving millions of cases. These mosquito-transmitted viruses cause inflammation and injury in skeletal muscle and joint tissues that results in debilitating pain. We previously...
Michael Kuncewitch et al.
Shock (Augusta, Ga.), 43(3), 268-275 (2014-12-17)
Renal ischemia-reperfusion (IR) injury (IRI) after shock states or transplantation causes tissue damage and delayed graft function, respectively. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis. We therefore hypothesized that pharmacological activation of the Wnt/β-catenin signaling by the...
Xiangyou Hu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3806-3814 (2015-03-06)
Inhibition of β-site APP cleaving enzyme 1 (BACE1) is being pursued as a therapeutic target for treating patients with Alzheimer's disease because BACE1 is the sole β-secretase for generating β-amyloid peptide. Knowledge regarding the other cellular functions of BACE1 is...
Mélanie Bourque et al.
Neurobiology of aging, 35(10), 2347-2356 (2014-04-15)
Raloxifene, used in the clinic, is reported to protect brain dopaminergic neurons in mice. Raloxifene was shown to mediate an effect through the G protein-coupled estrogen receptor 1 (GPER1). We investigated if raloxifene neuroprotective effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated male mice...
Fu Huang et al.
The Journal of biological chemistry, 290(48), 28760-28777 (2015-10-10)
Histone H3 lysine 4 (H3K4) methylation is a dynamic modification. In budding yeast, H3K4 methylation is catalyzed by the Set1-COMPASS methyltransferase complex and is removed by Jhd2, a JMJC domain family demethylase. The catalytic JmjC and JmjN domains of Jhd2...
Rui Du et al.
Journal of experimental & clinical cancer research : CR, 33, 105-105 (2014-12-17)
Brachyury overexpression has been reported in various human malignant neoplasms, but its expression and function in hepatocellular carcinoma progression and metastasis remains unknown. The present study aimed to evaluate the critical role of Brachyury in HCC metastasis. The expression of...
Zhichao Zhang et al.
Stem cells and development, 24(22), 2709-2722 (2015-07-16)
Promoting both endogenous and exogenous neural stem cells' (NSCs) survival in the hostile host environments is essential to cell replacement therapy for central nervous system (CNS) disorders. Type 4 metabotropic glutamate receptor (mGluR4), one of the members of mGluRs, has...
Lauren Endres et al.
PloS one, 10(7), e0131335-e0131335 (2015-07-07)
Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translational modification. Cellular responses to ROS...
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