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Kaisorn L Chaichana et al.
Journal of neuroscience methods, 180(1), 116-125 (2009-05-12)
The discoveries of neural (NSCs) and brain tumor stem cells (BTSCs) in the adult human brain and in brain tumors, respectively, have led to a new era in neuroscience research. These cells represent novel approaches to studying normal phenomena such...
Pei-Yu Liu et al.
Electrophoresis, 33(19-20), 3079-3086 (2012-09-22)
A CD-modified CE method was established for quantitative determination of seven hydroxy acids in cosmetic products. This method involved chemometric experimental design aspects, including fractional factorial design and central composite design. Chemometric experimental design was used to enhance the method's...
Mitsuru Hanada et al.
Connective tissue research, 55(5-6), 378-383 (2014-08-21)
The purpose of this study was to investigate biochemical differences in collagen crosslinks from different locations within the ligaments and a tendon of the human knee. The anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial collateral ligament (MCL), lateral...
Charles Finsterwald et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(48), 15903-15915 (2015-12-04)
Arousal and stress critically regulate memory formation and retention. Increasing levels of stress produce an inverted U-shaped effect on cognitive performance, including the retention of explicit memories, and experiencing a severe stress during a traumatic event may lead to posttraumatic...
Abdul-Rauf Ibrahim et al.
International journal of molecular sciences, 16(4), 7960-7975 (2015-04-11)
The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems)...
Veniero Gambaro et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 68-76 (2014-03-25)
In vitro incubation with human liver microsomes of JWH-018, JWH-073, JWH-122 and for the first time 1-butyl-3-(1-(4-methyl)naphthoyl)indole (the 4-methylnaphthoyl analogue of JWH-073) was investigated to identify the principal metabolites of alkylindole synthetic cannabinoids, thus helping the discovering of synthetic cannabinoids...
Sabine Hauptstein et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 132-139 (2014-07-16)
The study was aimed to developed and investigate a novel polymer for intestinal drug delivery with improved mucoadhesive properties. Therefore Eudragit® L 100-55 (poly(methacrylic acid-co-ethyl acrylate)) was thiolated by covalent attachment of L-cysteine. The immobilized thiol groups were preactivated by...
Tiago Souza Dos Santos et al.
Behavioural brain research, 295, 45-63 (2015-04-07)
Serotonin 1A receptors (5-HT1ARs), which are widely distributed in the mammalian brain, participate in cognitive and emotional functions. In birds, 5-HT1ARs are expressed in prosencephalic areas involved in visual and cognitive functions. Diverse evidence supports 5-HT1AR-mediated 5-HT-induced ingestive and sleep...
Yang-Chi Fan et al.
Journal of AOAC International, 98(3), 575-579 (2015-05-31)
Danofloxacin is an antibacterial drug of the fluoroquinolone group developed for therapeutic purposes in veterinary medicine. The studies described here include investigations of the residues following a single dose or multiple doses of danofloxacin. Residue depletion studies were performed to...
Zedong Li et al.
The Analyst, 140(16), 5526-5535 (2015-06-17)
The integration of paper with an electrochemical device has attracted growing attention for point-of-care testing, where it is of great importance to fabricate electrodes on paper in a low-cost, easy and versatile way. In this work, we report a simple...
Luisa Islas et al.
International journal of pharmaceutics, 488(1-2), 20-28 (2015-04-22)
Acrylic acid (AAc) and poly(ethylene glycol) methacrylate (PEGMA) were singly and dually grafted onto poly(vinyl chloride) (PVC) urinary catheters with the aim of preventing biofouling by endowing the catheters with the ability to load and release antimicrobial agents and to...
Li-Hua Mu et al.
Biological & pharmaceutical bulletin, 37(6), 1035-1041 (2014-06-03)
The aim of this study was to explore whether the ethanolic extract of Ardisia gigantifolia rhizomes (AGB-5), a traditional herbal medicine from China, could affect the proliferation of human breast adenocarcinoma (MCF-7) cells in vitro and to explore the antitumor...
Franziska E Uhl et al.
The European respiratory journal, 46(4), 1150-1166 (2015-05-02)
Chronic obstructive pulmonary disease (COPD) is characterised by a progressive loss of lung tissue. Inducing repair processes within the adult diseased lung is of major interest and Wnt/β-catenin signalling represents a promising target for lung repair. However, the translation of...
L Boysen et al.
Poultry science, 92(5), 1425-1429 (2013-04-11)
When assessing effects of decontamination techniques on counts of Campylobacter spp. on broiler meat, it is essential that the results reflect the variations that may exist. Decontamination studies often use high inoculation levels (10(7) to 10(8) cfu) and one or...
Kishore Cholkar et al.
AAPS PharmSciTech, 15(6), 1454-1467 (2014-07-02)
The purpose of this study was to develop a clear aqueous mixed nanomicellar formulation (MNF) of dexamethasone utilizing both D-α-tocopherol polyethylene glycol-1000 succinate (Vit E TPGS) and octoxynol-40 (Oc-40). In this study, Vit E TPGS and Oc-40 are independent variables....
F Vela-Soria et al.
Talanta, 129, 209-218 (2014-08-17)
The population is continuously exposed to endocrine disrupting chemicals (EDCs). This has influenced an increase in diseases and syndromes that are more frequent nowadays. Therefore, it is necessary to develop new analytical procedures to evaluate the exposure with the ultimate...
Hossein Abdolmohammad-Zadeh et al.
Analytica chimica acta, 881, 54-64 (2015-06-05)
A simple dispersive solid-phase micro-extraction method based on CoFe2O4 nano-particles (NPs) functionalized with 8-hydroxyquinoline (8-HQ) with the aid of sodium dodecyl sulfate (SDS) was developed for separation of Al(III) ions from aqueous solutions. Al(III) ions are separated at pH 7...
Anne-Lise Marie et al.
Journal of pharmaceutical and biomedical analysis, 111, 64-70 (2015-04-12)
With the aim to determine the binding affinity of a new generation of recombinant antithrombin (AT) toward heparin, we developed a dynamic equilibrium-affinity capillary electrophoresis (DE-ACE) method. This method allows the determination of an AT-heparin binding constant (Kd) directly from...
J Rodenas-Montano et al.
Journal of chromatography. A, 1344, 31-41 (2014-04-29)
In micellar liquid chromatography (MLC), chromatographic peaks are more evenly distributed compared to conventional reversed-phase liquid chromatography (RPLC). This is the reason that most procedures are implemented using isocratic elution. However, gradient elution may be still useful in MLC to...
Jun Yeul Lim et al.
International journal of pharmaceutics, 492(1-2), 127-136 (2015-07-19)
To evaluate the oxidative stability of proteins, a model protein, etanercept, was exposed to oxidative stress conditions using hydrogen peroxide. Various amino acids were also evaluated on their antioxidant effect. Transition temperature (Tm), secondary structural content, hydrodynamic size, and aggregation...
Hannah N Ladenhauf et al.
Pediatric surgery international, 28(8), 805-814 (2012-07-24)
Sodium phosphate-containing laxatives are commonly used as first-line treatment option for constipation in children and adolescents. Hyperphosphatemia is an infrequent, but potentially life-threatening complication of laxative application. We report a case series of three children exhibiting severe hyperphosphatemia and hypocalcemia...
Nicolas Gautschi et al.
International journal of pharmaceutics, 491(1-2), 218-230 (2015-07-02)
There is a growing interest in drug-phospholipid complexes and similar formulations that are mostly solid dispersions with high drug load. This study aims to explore the feasibility of such phospholipid-based solid dispersions as well as to characterize them. A particular...
Joseph T Morott et al.
Journal of pharmaceutical sciences, 104(1), 124-134 (2014-11-21)
The primary aim of this research was to produce successfully taste masked formulations of Sildenafil Citrate (SC) using hot-melt extrusion (HME) technology. Multiple screw configurations and polymeric carriers were evaluated for their effects on taste masking efficiency, which was assessed...
Dennis Åsberg et al.
Journal of chromatography. A, 1362, 206-217 (2014-09-06)
This is the first investigation in a series that aims to enhance the scientific knowledge needed for reliable analytical method transfer between HPLC and UHPLC using the quality by design (QbD) framework. Here, we investigated the differences and similarities from...
Mostafa Roosta et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 975, 34-39 (2014-12-09)
In the present study, for the first time, a new extraction method based on "ultrasound assisted microextraction-nanomaterial solid phase dispersion (UAME-NMSPD)" was developed to preconcentrate the low quantity of thymol and carvacrol in pharmaceutical samples prior to their HPLC-UV separation/determination....
Jiri Zeravik et al.
Food chemistry, 194, 432-440 (2015-10-17)
Biosensors based on lactate oxidase, sarcosine oxidase and mixture of fumarase and sarcosine oxidase were used for monitoring of organic acids in wine samples. Additionally, tartaric acid was determined by modified colorimetric method based on formation of the vanadate-tartrate complex....
Raquel dos Santos et al.
Journal of chromatography. A, 1355, 115-124 (2014-06-21)
In this work, phenylboronic acid (PBA) was thoroughly investigated as a synthetic ligand for the purification of an immunoglobulin G (IgG) from a clarified cell supernatant from Chinese Hamster Ovary (CHO) cell cultures. In particular, the study was focused on...
Andrea Cossu et al.
International journal of pharmaceutics, 493(1-2), 233-242 (2015-08-02)
Conventional antifungal treatments against Candida albicans in the oral cavity often result in increased cytotoxicity. The goal of this study was to determine the potential of starch Pickering emulsion as a delivery vehicle for an antifungal natural phenolic compound such...
Elena V Piletska et al.
The Analyst, 140(9), 3113-3120 (2015-03-10)
Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled fashion. The present study describes the preparation of magnetic nano-sized Molecularly...
Asdren Zajmi et al.
PloS one, 10(6), e0128157-e0128157 (2015-06-02)
Staphylococci are facultative anaerobes, perfectly spherical un-encapsulated cocci, with a diameter not exceeding 1 micrometer in diameter. Staphylococcus aureus are generally harmless and remain confined to the skin unless they burrow deep into the body, causing life-threatening infections in bones...
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