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Lenka Skalska et al.
The EMBO journal, 34(14), 1889-1904 (2015-06-13)
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target selection and gene activation in each context. To investigate the influence of chromatin organisation and dynamics on the response to Notch signalling, we
Yiming Zheng et al.
Nature cell biology, 22(3), 297-309 (2020-02-19)
Non-centrosomal microtubule-organizing centres (ncMTOCs) have a variety of roles that are presumed to serve the diverse functions of the range of cell types in which they are found. ncMTOCs are diverse in their composition, subcellular localization and function. Here we
Chenyu Pan et al.
EMBO reports, 18(11), 1922-1934 (2017-09-10)
The Hh pathway controls many morphogenetic processes in metazoans and plays important roles in numerous pathologies and in cancer. Hh signaling is mediated by the activity of the Gli/Ci family of transcription factors. Several studies in
Zoe Pillidge et al.
EMBO reports, 20(5) (2019-03-28)
Notch signaling plays a key role in many cell fate decisions during development by directing different gene expression programs via the transcription factor CSL, known as Su(H) in Drosophila Which target genes are responsive to Notch signaling is influenced by
Natalie J Kirkland et al.
Current biology : CB, 30(13), 2419-2432 (2020-05-16)
Cell divisions are essential for tissue growth. In pseudostratified epithelia, where nuclei are staggered across the tissue, each nucleus migrates apically before undergoing mitosis. Successful apical nuclear migration is critical for planar-orientated cell divisions in densely packed epithelia. Most previous
Katrin Strassburger et al.
Development (Cambridge, England), 144(13), 2529-2538 (2017-05-21)
The
Giri Raj Dahal et al.
Development (Cambridge, England), 144(15), 2771-2783 (2017-07-08)
Loss of embryonic ion channel function leads to morphological defects, but the underlying reason for these defects remains elusive. Here, we show that inwardly rectifying potassium (Irk) channels regulate release of the
Sarah Mische et al.
Molecular biology of the cell, 19(11), 4918-4929 (2008-09-19)
The dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. Previous work has established that the LIC homodimer binds directly to the dynein
Shuhei Kimura
FEBS letters, 587(7), 922-929 (2013-03-05)
Spermiogenesis is a dynamic process leading to alterations in cell morphology. In spermiogenesis, the roles of the histone chaperones are largely unknown. Here, I report the unexpected roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1)
Raquel Perez-Gomez et al.
Scientific reports, 10(1), 4401-4401 (2020-03-12)
Mitochondrial dysfunctions belong amongst the most common metabolic diseases but the signalling networks that lead to the manifestation of a disease phenotype are often not well understood. We identified the subunits of respiratory complex I, III and IV as mediators
Emily Tubman et al.
Cellular and molecular bioengineering, 11(1), 25-36 (2018-03-20)
The microtubule motor protein kinesin-5 is well known to establish the bipolar spindle by outward sliding of antiparallel interpolar microtubules. In yeast, kinesin-5 also facilitates chromosome alignment "congression" at the spindle equator by preferentially depolymerizing long kinetochore microtubules (kMTs). The
Arthur Luhur et al.
G3 (Bethesda, Md.), 10(12), 4541-4551 (2020-10-09)
Successful Drosophila cell culture relies on media containing xenogenic components such as fetal bovine serum to support continuous cell proliferation. Here, we report a serum-free culture condition that supports the growth and proliferation of Drosophila S2R+ and Kc167 cell lines.
Taiichi Tsuyama et al.
The Journal of cell biology, 216(3), 815-834 (2017-02-18)
Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism specifically impact neuronal intracellular processes and cause neuropathological events is still unclear. We here dissect the molecular mechanism by which
Stephen K K Chan et al.
PLoS genetics, 13(11), e1007096-e1007096 (2017-11-21)
Repressors are frequently deployed to limit the transcriptional response to signalling pathways. For example, several co-repressors interact directly with the DNA-binding protein CSL and are proposed to keep target genes silenced in the absence of Notch activity. However, the scope
Rosalind Hale et al.
eLife, 4 (2015-02-25)
To understand how long-range patterning gradients are interpreted at the cellular level, we investigate how a gradient of expression of the Four-jointed kinase specifies planar polarised distributions of the cadherins Fat and Dachsous in the Drosophila wing. We use computational
Ahmed Sabri et al.
PloS one, 6(4), e18847-e18847 (2011-04-29)
Aphidius ervi (Hymenoptera: Braconidae) is an entomophagous parasitoid known to be an effective parasitoid of several aphid species of economic importance. A reduction of its production cost during mass rearing for inundative release is needed to improve its use in
Remigio Picone et al.
PLoS biology, 8(11), e1000542-e1000542 (2010-11-26)
Because physical form and function are intimately linked, mechanisms that maintain cell shape and size within strict limits are likely to be important for a wide variety of biological processes. However, while intrinsic controls have been found to contribute to
Remigio Picone et al.
PLoS biology, 8(11), e1000542-e1000542 (2010-11-26)
Because physical form and function are intimately linked, mechanisms that maintain cell shape and size within strict limits are likely to be important for a wide variety of biological processes. However, while intrinsic controls have been found to contribute to
Min Zhao et al.
Genetics, 178(4), 1947-1971 (2008-04-24)
Fasciclin2 (Fas2) and Discslarge (Dlg) localize to the basolateral junction (BLJ) of Drosophila follicle epithelial cells and inhibit their proliferation and invasion. To identify a BLJ signaling pathway we completed a genomewide screen for mutants that enhance dlg tumorigenesis. We
Kentaro Kato et al.
PLoS biology, 9(8), e1001133-e1001133 (2011-09-14)
Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces
Y Asano et al.
HFSP journal, 3(3), 194-203 (2009-07-30)
Lamellipodia are broad actin-based structures that define the protruding edge of many motile animal cells. Here we identify a Drosophila homolog of the p21-activated kinases (Paks) as a novel inhibitor of Rac-mediated lamellipodial formation: Pak3 overexpression mimics a loss of
Xueyang Pan et al.
Current biology : CB, 29(17), 2840-2851 (2019-08-20)
Properly timed production of steroid hormones by endocrine tissues regulates juvenile-to-adult transitions in both mammals (puberty) and holometabolous insects (metamorphosis). Nutritional conditions influence the temporal control of the transition, but the mechanisms responsible are ill defined. Here we demonstrate that
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
Himani Pathak et al.
Life science alliance, 4(8) (2021-06-19)
In Drosophila, nutrient status is sensed by the fat body, a functional homolog of mammalian liver and white adipocytes. The fat body conveys nutrient information to insulin-producing cells through humoral factors which regulate Drosophila insulin-like peptide levels and insulin signalling.
Nathan D Elrod et al.
Molecular cell, 76(5), 738-752 (2019-12-07)
The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in early elongation, remaining engaged with the 25- to 60-nt-long nascent
Maria-Del-Carmen Diaz-de-la-Loza et al.
Developmental cell, 46(1), 23-39 (2018-07-06)
Epithelial tissues can elongate in two dimensions by polarized cell intercalation, oriented cell division, or cell shape change, owing to local or global actomyosin contractile forces acting in the plane of the tissue. In addition, epithelia can undergo morphogenetic change
Shuhei Kimura
FEBS letters, 587(7), 922-929 (2013-03-05)
Spermiogenesis is a dynamic process leading to alterations in cell morphology. In spermiogenesis, the roles of the histone chaperones are largely unknown. Here, I report the unexpected roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1)
Caroline Mauvezin et al.
Nature communications, 6, 7007-7007 (2015-05-12)
The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with incoming vesicles from the autophagic
Brian J Beliveau et al.
Nature communications, 6, 7147-7147 (2015-05-13)
Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying nuclear structure and organization. Here we report two advances in FISH-based imaging. We first describe the in situ visualization of single-copy regions of the genome using two single-molecule
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