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Ulrike Fischer et al.
Oncotarget, 6(9), 7023-7039 (2015-03-12)
In development of amphibians and flies, gene amplification is one of mechanisms to increase gene expression. In mammalian cells, gene amplification seems to be restricted to tumorigenesis and acquiring of drug-resistance in cancer cells. Here, we report a complex gene...
Valerie L Flax et al.
The American journal of clinical nutrition, 99(4), 950-956 (2014-02-07)
Selenium is found in soils and is essential for human antioxidant defense and immune function. In Malawi, low soil selenium and dietary intakes coupled with low plasma selenium concentrations in HIV infection could have negative consequences for the health of...
Simon P W Hageman et al.
Water research, 47(7), 2118-2128 (2013-03-15)
Removal of the toxic selenium compounds selenite and selenate from waste water before discharge is becoming increasingly imperative in industrialized countries. Bacteria can reduce selenate to selenite, but also further to elemental selenium, selenide or organic selenium. In this paper...
Hong Gao et al.
Environmental toxicology and pharmacology, 37(3), 1079-1089 (2014-05-02)
The aim of this work was to investigate genomic DNA damage in human oral cavity cells after exposure to different tobacco product preparations (TPPs). The oral carcinoma cell line 101A, gingival epithelial cells HGEC, and gingival fibroblasts HGF were exposed...
Kenjiro Bandow et al.
Bone, 74, 125-133 (2014-12-17)
Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been...
Youbin Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(5), 1986-1998 (2015-04-15)
Urothelial carcinoma-associated 1 (UCA1) is a recently identified long non coding RNA (lncRNA). However, few studies have explored its role in cardiomyocytes after focal cardiac ischemia reperfusion injury (CIR). Rat CIR models were established using ligation of the Lower Anterior...
Simon Pecha et al.
Scientific reports, 9(1), 9831-9831 (2019-07-10)
Human iPSC-derived engineered heart tissue (hEHT) has been used to remuscularize injured hearts in a guinea pig infarction model. While beneficial effects on cardiac remodeling have been demonstrated, the arrhythmogenic potential of hEHTs is a major concern. We investigated whether...
Carla Mulas et al.
Lab on a chip, 20(14), 2580-2591 (2020-06-24)
Combining live imaging with the ability to retrieve individual cells of interest remains a technical challenge. Combining imaging with precise cell retrieval is of particular interest when studying highly dynamic or transient, asynchronous, or heterogeneous cell biological and developmental processes....
Kun Wang et al.
Nature communications, 6, 6779-6779 (2015-04-11)
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report...
Maria Teresa Dell'Anno et al.
The Journal of clinical investigation, 124(7), 3215-3229 (2014-06-18)
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional...
Yuka Hattori et al.
PloS one, 10(10), e0140121-e0140121 (2015-10-29)
Acute kidney injury (AKI) is a critical condition associated with high mortality. However, the available treatments for AKI are limited. Stem cells from human exfoliated deciduous teeth (SHED) have recently gained attention as a novel source of stem cells. The...
Arumugam Ramachandran Muralidharan et al.
Journal of chemical information and modeling, 55(8), 1686-1697 (2015-08-14)
Calpains belong to the family of calcium-dependent, structurally related intracellular cysteine proteases that exhibit significant functions in evolution of different types of cataracts in human as well as animal models. Application of calpain inhibitors generated through a virtual screening workflow...
Chien-Chia Su et al.
Molecular vision, 21, 633-643 (2015-06-23)
To optimize isolation of viable bovine corneal endothelial cells (BCECs), we evaluated the effectiveness of various preparation protocols. This entailed comparing the effects of collagenase A and trypsin in the presence and absence of a Rho kinase inhibitor, Y-27632, on...
Riham S Said et al.
PloS one, 7(12), e50928-e50928 (2012-12-14)
Radiotherapy is a major factor contributing to female infertility by inducing premature ovarian failure (POF). Therefore, the need for an effective radioprotective agent is evident. The present study investigated the mechanism of potential radioprotective effect of sodium selenite on radiation-induced...
Catarina Galinha et al.
Journal of food science and technology, 52(7), 4236-4245 (2015-07-04)
Agronomic biofortification of staple crops is an effective way to enhance their contents in essential nutrients up the food chain, with a view to correcting for their deficiencies in animal or human status. Selenium (Se) is one such case, for...
Celine Thiry et al.
Biological trace element research, 152(1), 152-160 (2013-02-12)
Most European people have selenium (Se) intake inferior to recommended values that are considered necessary to ensure the beneficial action of antioxidant selenoproteins. People could therefore tend to have recourse to Se-enriched food supplements (FS) aiming to increase their Se...
Stephanie Graser et al.
Bone, 79, 150-161 (2015-06-03)
Patients suffering from the rare hereditary disease hypophosphatasia (HPP), which is based on mutations in the ALPL gene, tend to develop central nervous system (CNS) related issues like epileptic seizures and neuropsychiatric illnesses such as anxiety and depression, in addition...
J-Y Wang et al.
Oncogene, 34(33), 4358-4367 (2014-11-11)
Tumor metastasis is the major cause of death among cancer patients, with >90% of cancer-related death attributable to the spreading of metastatic cells to secondary organs. Store-operated Ca(2+) entry (SOCE) is the predominant Ca(2+) entry mechanism in most cancer cells...
D A McCreedy et al.
Biomaterials science, 2(11), 1672-1682 (2014-10-28)
Embryonic stem (ES) cells can be differentiated into many neural cell types that hold great potential as cell replacement therapies following spinal cord injury (SCI). Coupling stem cell transplantation with biomaterial scaffolds can produce a unified combination therapy with several...
Dominique J P M Stumpel et al.
European journal of cancer (Oxford, England : 1990), 51(14), 2008-2021 (2015-07-21)
MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of childhood ALL, displaying a chemotherapy-resistant phenotype, and unique histone modifications, gene expression signatures and DNA methylation patterns. MLL-rearranged infant ALL responds remarkably well to nucleoside analogue drugs...
Franziska Hiller et al.
Inflammatory bowel diseases, 21(9), 2078-2089 (2015-06-27)
The selenoprotein glutathione peroxidase 2 (GPx2) is highly expressed in the gastrointestinal epithelium. During inflammatory bowel disease and colorectal cancer, GPx2 expression is enhanced. We analyzed GPx2 expression and transcriptional regulation during the different phases of dextran sulfate sodium (DSS)-induced...
Y Ci et al.
Cell death & disease, 5, e1542-e1542 (2014-11-28)
Reactive oxygen species (ROS) have an important role in regulating various cellular processes. Our previous study confirmed that selenite, an anti-tumour agent, triggered apoptosis through the production of ROS in multiple types of cancer cells. In this study, we discovered...
Nikolce Gjorevski et al.
Scientific reports, 5, 11458-11458 (2015-07-15)
Collective cell migration drives tissue remodeling during development, wound repair, and metastatic invasion. The physical mechanisms by which cells move cohesively through dense three-dimensional (3D) extracellular matrix (ECM) remain incompletely understood. Here, we show directly that migration of multicellular cohorts...
Kang Sun et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 36-41 (2012-11-10)
Selenium, an essential trace element, can also be toxic at higher levels of exposure. Several lines of evidence show epigallocatechin-3-gallate (EGCG), a predominant component of green tea catechins with numerous health benefits, can ameliorate the toxicity of many agents. A...
Zhu-Xu Zhang et al.
Transplantation, 99(5), 916-924 (2015-02-27)
Chronic allograft injury remains the leading cause of late kidney graft loss despite improvements in immunosuppressive drugs and a reduction in acute T cell-mediated rejection. We have recently demonstrated that natural killer (NK) cells are cytotoxic to tubular epithelial cells...
Young-Hoon Kim et al.
Nature communications, 6, 7451-7451 (2015-06-17)
Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion...
Dongmei Sun et al.
Molecular and cellular biochemistry, 401(1-2), 21-26 (2014-12-03)
L-Sox5 is a member of sex-determining region Y-type high mobility group box (SOX) family of transcription factors. We assessed the effects of retroviral overexpression of L-Sox5 on chondrocyte differentiation using the clonal murine cell line ATDC5. We observed a temporal-restricted...
Kun Wang et al.
Nature communications, 6, 7619-7619 (2015-07-18)
Mitochondrial fragmentation plays an important role in the progression of cardiac diseases, such as myocardial infarction and heart failure. Mitochondrial network is controlled by many factors in different cell types. Here we show that the interplay between E2F1, miR-421 and...
Tamara Winkler et al.
PloS one, 9(6), e98444-e98444 (2014-06-04)
Intervertebral discs (IVDs) are strong fibrocartilaginous joints that connect adjacent vertebrae of the spine. As discs age they become prone to failure, with neurological consequences that are often severe. Surgical repair of discs treats the result of the disease, which...
Canonical TGF-beta signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression
Nakashima H, et al.
The Journal of Neuroscience, 2423-2417 (2018)
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