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" within Papeles
Serafula Filou et al.
PloS one, 10(3), e0121209-e0121209 (2015-03-19)
ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion, proliferation and migration. Through their thrombospondin
Rana N El-Danaf et al.
Neural development, 10, 19-19 (2015-07-16)
The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been the primary focus, however much less is known about the maturation of
Tuoen Liu et al.
Cancer letters, 357(1), 231-241 (2014-12-03)
We previously identified and characterized a 66-68 kDa membrane-associated, tyrosine phosphorylated protein in murine leukemia L1210 cells as HSC70 which is a methotrexate (MTX)-binding protein. In order to further characterize the functional role of HSC70 in regulating MTX resistance in L1210
Bei Liu et al.
Molecular neurobiology, 50(2), 327-338 (2014-01-28)
Efflux of monocaroxylates like lactate, pyruvate, and ketone bodies from astrocytes through monocarboxylate transporter 4 (MCT4) supplies the local neuron population with metabolic intermediates to meet energy requirements under conditions of increased demand. Disruption of this astroglial-neuron metabolic coupling pathway
Maria D Dănilă et al.
Canadian journal of physiology and pharmacology, 93(9), 819-825 (2015-09-01)
Monoamine oxidases (MAOs) have recently emerged as important mitochondrial sources of oxidative stress in the cardiovascular system. Generation of reactive oxygen species during the brief episodes of ischemic preconditioning (IPC) is responsible for the cardioprotection at reperfusion. The aim of
Katja Horling et al.
Human molecular genetics, 24(4), 1007-1018 (2014-10-10)
In humans, lack of phenylalanine hydroxylase (Pah) activity results in phenylketonuria (PKU), which is associated with the development of severe mental retardation after birth. The underlying mechanisms, however, are poorly understood. Mutations of the Pah gene in Pah(enu2)/c57bl6 mice result
Zenan Wang et al.
Journal of applied toxicology : JAT, 35(8), 909-917 (2014-12-17)
Conventional two-dimensional (2D) monolayer cultures of HepaRG cells allow in vitro maintenance of many liver-specific functions. However, cellular dedifferentiation and functional deterioration over an extended culture period in the conventional 2D HepaRG culture have hampered its applications in drug testing.
JiYoung Hong et al.
Virology journal, 12, 101-101 (2015-07-05)
In Korea, every vaccine lot is tested by the National Center for Lot Release (NCLR) in accordance with the national lot release procedures to ensure the safety and efficacy of vaccines. These quality tests examine the virus content in varicella
Guang Rong et al.
Journal of physiology and biochemistry, 71(3), 455-470 (2015-07-23)
Although podocyte apoptosis has been shown to be induced by the accumulation of advanced oxidation protein products (AOPPs), the mechanisms through which AOPPs trigger apoptosis in these cells remain unclear. In this study, we investigated the role of endoplasmic reticulum
Julien Heroult et al.
Analytical and bioanalytical chemistry, 406(16), 3919-3927 (2014-05-13)
This work represents a first systematic approach to the size-based elemental quantification and size estimation of metal(loid) oxide nanoparticles such as silica (SiO2) in a real food matrix using asymmetric flow field-flow fractionation coupled online with inductively coupled plasma mass
Federica Ianni et al.
Journal of pharmaceutical and biomedical analysis, 116, 40-46 (2015-01-27)
In two-dimensional HPLC (2D-HPLC) "heart-cut" applications, two columns are connected in series via a switching valve and volume fractions from the "primary" column are re-injected on the "secondary" column. The heart-cut 2D-HPLC system here described was implemented by connecting a
Ana Sousa-Herves et al.
Nanoscale, 7(9), 3933-3940 (2014-12-23)
An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated
Céline Lacroix et al.
The Journal of antimicrobial chemotherapy, 69(10), 2723-2732 (2014-06-21)
To study the characteristics and the mode of action of the anti-rhinovirus compound 4-[1-hydroxy-2-(4,5-dimethoxy-2-nitrophenyl)ethyl]benzonitrile (LPCRW_0005). The antiviral activity of LPCRW_0005 was evaluated in a cytopathic effect reduction assay against a panel of human rhinovirus (HRV) strains. To unravel its precise
Andrea Derksen et al.
PloS one, 9(10), e110089-e110089 (2014-10-11)
Infections by influenza A viruses (IAV) are a major health burden to mankind. The current antiviral arsenal against IAV is limited and novel drugs are urgently required. Medicinal plants are known as an abundant source for bioactive compounds, including antiviral
Richard R Goulet et al.
Environmental toxicology and chemistry, 34(3), 562-574 (2014-12-06)
Treated effluent discharge from uranium (U) mines and mills elevates the concentrations of U, calcium (Ca), magnesium (Mg), and sulfate (SO4 (2-) ) above natural levels in receiving waters. Many investigations on the effect of hardness on U toxicity have
K-W Lee et al.
Molecular psychiatry, 20(12), 1546-1556 (2015-09-16)
Mood disorders and antidepressant therapy involve alterations of monoaminergic and glutamatergic transmission. The protein S100A10 (p11) was identified as a regulator of serotonin receptors, and it has been implicated in the etiology of depression and in mediating the antidepressant actions
Hehai Pan et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(8), 1523-1535 (2015-02-14)
LIM mineralization protein-1 (LMP-1) is an intracellular regulator of bone formation. Upregulation of bone morphogenetic proteins (BMPs) and stabilization of BMP/Smad signaling have been proven to be the key mechanisms through which LMP-1 enhances osteogenesis. However, how LMP-1 regulates BMPs
Harvey L Bumpers et al.
The Journal of surgical research, 194(2), 319-326 (2015-01-27)
Innovative technologies for drug discovery and development, cancer models, stem cell research, tissue engineering, and drug testing in various cell-based platforms require an application similar to the in vivo system. We developed for the first time nanomagnetically levitated three-dimensional (3-D) cultures
Damião Pergentino de Sousa et al.
Natural product communications, 10(11), 1893-1896 (2016-01-12)
Aromatic plants produce volatile substances with high therapeutic potential. In view of the need for new respiratory and cardiovascular system pharmacological agents, the present study reports on the spasmolytic activity of two enantiomers of carvone and limonene, constituents of essential
Marie R Webster et al.
Pigment cell & melanoma research, 28(2), 184-195 (2014-11-20)
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond
Jing-Shu Zhang et al.
PloS one, 10(3), e0122175-e0122175 (2015-03-26)
Tocotrienols have been shown many biologic functions such as antioxidant, anti-cancer, maintaining fertility and regulating the immune system and so on. In this study, after feeding with tocotrienol-rich fraction from palm oil (TRF) for 2 weeks, Balb/c nude mice were
Baiping Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(40), 13314-13325 (2014-10-03)
Impaired neurogenesis in the adult hippocampus has been implicated in AD pathogenesis. Here we reveal that the APP plays an important role in the neural progenitor proliferation and newborn neuron maturation in the mouse dentate gyrus. APP controls adult neurogenesis
P Ranawat et al.
Andrologia, 46(6), 650-658 (2013-07-16)
Resveratrol has been considered as an antioxidant in biological system. However, its role in male reproductive biology has not yet been evaluated in much detail. Present study analysed its effect on male reproductive function in adult mouse, after its intraperitoneal
Oesophageal bezoar induced by black beans successfully removed by associating endoscopy and oral sodium bicarbonate.
Miao-Yan Chen et al.
Acta gastro-enterologica Belgica, 76(3), 347-347 (2013-11-23)
Antonio Lacquaniti et al.
Radiology, 267(1), 86-93 (2013-01-09)
To evaluate the utility of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) in depicting an event of contrast material-induced nephropathy (CIN) in patients who received iodinated contrast media, gadoterate meglumine, or radiopharmaceutical technetium-99m ((99m)Tc) and to evaluate the protective effect
Oriol Penon et al.
Journal of colloid and interface science, 462, 154-165 (2015-10-12)
The preparation of novel porphyrin derivatives and their immobilization onto iron oxide nanoparticles to build up suitable nanotools for potential use in photodynamic therapy (PDT) has been explored. To achieve this purpose, a zinc porphyrin derivative, ZnPR-COOH, has been synthesized
Matthew A Churchward et al.
Molecular brain, 7, 85-85 (2014-11-27)
As the primary immune cells of the central nervous system, microglia contribute to development, homeostasis, and plasticity of the central nervous system, in addition to their well characterized roles in the foreign body and inflammatory responses. Increasingly, inappropriate activation of
J Matos et al.
Environmental research, 143(Pt B), 123-129 (2015-09-28)
This study aimed to identify the benefit and risk associated with raw and cooked blue shark consumption taking into account the bioaccessibility of Se, Hg and MeHg, by using in vitro digestion method. Selenium, Hg and MeHg levels were higher
Girish Ramachandran et al.
PLoS neglected tropical diseases, 9(1), e3394-e3394 (2015-01-09)
Invasive non-typhoidal Salmonella (iNTS) are an important cause of septicemia in children under the age of five years in sub-Saharan Africa. A novel genotype of Salmonella enterica subsp. enterica serovar Typhimurium (multi-locus sequence type [ST] 313) circulating in this geographic
Fengtian Xue et al.
CNS & neurological disorders drug targets, 13(4), 558-566 (2013-10-31)
Traumatic brain injury causes progressive neurodegeneration associated with chronic microglial activation. Recent studies show that neurodegeneration and neuroinflammation after traumatic brain injury can be inhibited as late as one month in animals by the activation of the metabotropic glutamate receptor
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