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Young-Eui Kim et al.
PLoS pathogens, 11(3), e1004785-e1004785 (2015-03-27)
Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such as cell proliferation, apoptosis, gene regulation, and DNA damage response. PML also acts as a restriction
Biao Wang et al.
Oncotarget, 6(18), 16019-16030 (2015-04-25)
The oncolytic measles virus Edmonston (MV-Edm) strain shows considerable oncolytic activity against a variety of human tumors. In this study, we report MV-Edm is able to trigger apoptosis pathways in infected tumor cells and elucidate the roles of cellular apoptosis
Patrick Scheiermann et al.
Scientific reports, 5, 8521-8521 (2015-02-18)
Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner
Huiqing Liang et al.
International journal of molecular sciences, 16(11), 27749-27756 (2015-11-28)
Gardenoside is one of the most important effective extractions of a herb for its hepatoprotective properties. The aim of this study was to address the mechanism of Gardenoside on HepG2 cellular steatosis induced by free fatty acids (FFAs). The model
Erin K Z Kirschmann et al.
Learning & memory (Cold Spring Harbor, N.Y.), 21(11), 606-615 (2014-10-18)
Conditioned stimuli (CS) can modulate reward-seeking behavior. This modulatory effect can be maladaptive and has been implicated in excessive reward seeking and relapse to drug addiction. We previously demonstrated that exposure to an appetitive CS causes an increase in the
Jean-Nicolas Gallant et al.
Cancer discovery, 5(11), 1155-1163 (2015-08-20)
Oncogenic EGFR mutations are found in 10% to 35% of lung adenocarcinomas. Such mutations, which present most commonly as small in-frame deletions in exon 19 or point mutations in exon 21 (L858R), confer sensitivity to EGFR tyrosine kinase inhibitors (TKI).
Lenka Roubalová et al.
Bioorganic & medicinal chemistry, 23(17), 5402-5409 (2015-08-12)
Quercetin 3'-O-sulfate is one of the main metabolites of the natural flavonoid quercetin in humans. This study was designed to prepare quercetin 3'-O-sulfate (1), isoquercitrin 4'-O-sulfate (2) and taxifolin 4'-O-sulfate (3) by the sulfation of quercetin, isoquercitrin (quercetin 3-O-glucoside) and
X Teng et al.
Oral diseases, 21(2), 185-194 (2014-03-13)
Heightened levels of sEcad are found in the serum of patients with cancer and correlate with an unfavorable prognosis and later-stages of disease. In this study, we explored whether sEcad is elevated in human OPSCC specimens and FaDu cells. Additionally
Nathalie Kersual et al.
mAbs, 6(5), 1314-1326 (2014-12-18)
Ovarian cancer has the highest mortality rate among gynecologic malignancies. The monoclonal antibody 12G4 specifically recognizes the human Müllerian inhibiting substance type II receptor (MISRII) that is strongly expressed in human granulosa cell tumors (GCT) and in the majority of
Anne-Theres Henze et al.
Nature communications, 5, 5582-5582 (2014-11-26)
Solid tumours are exposed to microenvironmental factors such as hypoxia that normally inhibit cell growth. However, tumour cells are capable of counteracting these signals through mechanisms that are largely unknown. Here we show that the prolyl hydroxylase PHD3 restrains tumour
Bruna L B Pereira et al.
Nutrients, 7(11), 9640-9649 (2015-11-28)
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n
J Schrader et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(2), 118-125 (2014-11-14)
Class 1A phosphoinositide 3-kinase (PI3K) is essential for beta-cell growth and survival. Although PI3K has been studied extensively in diabetes the effect of alternatively spliced isoforms of the catalytic subunit p85α on beta cell proliferation and survival remains to be
Shingo Shimada et al.
Surgery today, 45(7), 892-903 (2014-11-05)
Hydrogen sulfide (H2S) ameliorates hepatic ischemia and reperfusion injury (IRI), but the precise mechanism remains elusive. We investigated whether sodium hydrogen sulfide (NaHS), a soluble derivative of H2S, would ameliorate hepatic IRI, and if so, via what mechanism. Mice were
Evelyn E Newby et al.
International dental journal, 63 Suppl 2, 39-47 (2014-01-10)
To compare the effect of 40 seconds versus 2 minutes brushing on saliva and dental biofilm fluid fluoride in children ages 4-5 years over 1 hour. This was a single-blind, cross-over, randomised, two-period clinical study in healthy children. Three days
Cuyue Tang et al.
Biochemical pharmacology, 91(4), 543-551 (2014-08-06)
Two investigational compounds (FRM-1, (R)-7-fluoro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and FRM-2, (R)-7-cyano-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide) resided in rat brain longer than in systemic circulation. In Caco-2 directional transport studies, they both showed good intrinsic passive permeability but differed significantly in efflux susceptibility (efflux ratio of <2 and
Irene Gallina et al.
Nature communications, 6, 6533-6533 (2015-03-31)
DNA replication stress is a source of genomic instability. Here we identify changed mutation rate 1 (Cmr1) as a factor involved in the response to DNA replication stress in Saccharomyces cerevisiae and show that Cmr1--together with Mrc1/Claspin, Pph3, the chaperonin
L N Munsie et al.
Human molecular genetics, 24(6), 1691-1703 (2014-11-25)
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosomal protein sorting and intracellular trafficking. We recently linked a mutation in VPS35 (p.D620N) to familial parkinsonism. Here, we characterize human VPS35 and retromer function
Hyung Suk Oh et al.
mBio, 6(3), e00345-e00315 (2015-05-28)
We have shown previously that A-type lamins and intranuclear localization of the herpes simplex virus (HSV) genome are critical for the formation of the VP16 activator complex on HSV immediate-early (IE) gene promoters in murine cells, which implies a critical
Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3
Zou B, et al.
Oncology Reports, 38(3), 1431-1441 (2017)
Saif Ahmad et al.
Journal of neuroimmunology, 277(1-2), 96-104 (2014-12-03)
Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previously demonstrated that the anti-inflammatory effect of
Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty
Marianne Le Gall et al.
Molecular cancer therapeutics, 14(11), 2595-2605 (2015-09-12)
KIT is a cell surface tyrosine kinase receptor whose ligand stem cell factor (SCF) triggers homodimerization and activation of downstream effector pathways involved in cell survival, proliferation, homing, or differentiation. KIT-activating mutations are major oncogenic drivers in subsets of acute
Dominique A Salazar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(25), 9315-9328 (2015-06-26)
Mutations in the human progranulin gene resulting in protein haploinsufficiency cause frontotemporal lobar degeneration with TDP-43 inclusions. Although progress has been made in understanding the normal functions of progranulin and TDP-43, the molecular interactions between these proteins remain unclear. Progranulin
M Yue et al.
Neurobiology of disease, 78, 172-195 (2015-04-04)
Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase
Teresa Obis et al.
Molecular brain, 8(1), 80-80 (2015-12-03)
Various protein kinase C (PKC) isoforms contribute to the phosphorylating activity that modulates neurotransmitter release. In previous studies we showed that nPKCε is confined in the presynaptic site of the neuromuscular junction and its presynaptic function is activity-dependent. Furthermore, nPKCε
Ratchada Cressey et al.
Indian journal of experimental biology, 52(12), 1173-1181 (2015-02-06)
In this study, we explored the effects of consumption of banana in thirty hypercholesterolemic and fifteen type 2 diabetic subjects. They were given a daily dose of 250 or 500 grams of banana for breakfast for 12 weeks. Fasting serum
Yasmina Belarbi et al.
The Journal of clinical endocrinology and metabolism, 100(8), E1084-E1088 (2015-05-29)
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. In white adipose tissue (WAT), recent studies suggest that miRNA levels are altered in various metabolic diseases, including obesity. The objective of the study was to determine whether adipocyte-expressed miRNAs altered by
Petcharat Kraivaphan et al.
The Journal of clinical dentistry, 24(1), 20-24 (2013-04-04)
The purpose of this study was to determine the viability of dental plaque at 12 hours following brushing with Colgate Great Regular Flavor (0.83% MFP), Crest Pro-Health (0.454% SnF), and Colgate Total Clean Mint Toothpaste (0.3% triclosan/ copolymer/0.22% NaF). Thirty-two
J P Randall et al.
Australian dental journal, 60(3), 368-374 (2014-10-29)
Streptococcus mutans is an important bacterial species implicated in dental caries. This laboratory study compared the antimicrobial activity of a number of fluoride containing and herbal dentifrices and their components against S. mutans. An agar diffusion method was used with
J Juhasova et al.
Cellular and molecular neurobiology, 35(1), 57-70 (2014-12-10)
Expression of doublecortin (DCX), a 43-53 kDa microtubule binding protein, is frequently used as (i) an early neuronal marker to identify the stage of neuronal maturation of in vivo grafted neuronal precursors (NSCs), and (ii) a neuronal fate marker transiently
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