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Justin L Luebke et al.
Metallomics : integrated biometal science, 5(4), 335-342 (2013-02-07)
Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor) is a member of the CsoR family of transition metal sensing metalloregulatory proteins. Unlike CsoR, CstR does not form a stable complex with transition metals but instead reacts with sulfite to form a...
Hui Liu et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 483-491 (2014-09-24)
Leydig cells are the primary source of testosterone in the testes, and their steroidogenic function is strictly controlled by the hypothalamus-pituitary-gonad axis. Emerging evidence has indicated that fibroblast growth factors play a role in regulating stem Leydig cell development and...
Dan Vershkov et al.
Cell reports, 26(10), 2531-2539 (2019-03-07)
Fragile X syndrome (FXS) is caused primarily by a CGG repeat expansion in the FMR1 gene that triggers its transcriptional silencing. In order to investigate the regulatory layers involved in FMR1 inactivation, we tested a collection of chromatin modulators for...
Towards obtaining long term embryonic stem cell like cultures from a marine flatfish, Scophtalmus maximus
Holen E and Hamre K
Fish Physiology and Biochemistry, 29(3), 245-252 (2003)
Dongwook Lee et al.
Fish physiology and biochemistry, 41(6), 1569-1576 (2015-08-05)
This study was conducted to identify embryonic stem cell (ESC) activities of a long-term cultured embryonic cell line previously derived from blastula-stage Oryzias dancena embryos. Five sub-cell lines were established from the embryonic cell line via clonal expansion of single...
H Luo et al.
Cell death & disease, 4, e481-e481 (2013-02-09)
Mounting evidence shows that selenium possesses chemotherapeutic potential against tumor cells, including leukemia, prostate cancer and colorectal cancer (CRC) cells. However, the detailed mechanism by which sodium selenite specifically kills tumor cells remains unclear. Herein, we demonstrated that supranutritional doses...
Larbi Amazit et al.
The Journal of biological chemistry, 290(36), 21876-21889 (2015-07-24)
Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are clinically useful for...
Arti Shukla et al.
The American journal of pathology, 175(5), 2197-2206 (2009-10-10)
Little is known about the cellular mechanisms contributing to the development and chemoresistance of malignant mesothelioma (MM), an aggressive asbestos-associated tumor. A human mesothelial cell line (LP9/TERT-1) and isolated human pleural mesothelial cells showed rapid and protracted asbestos-induced cAMP response...
J I Eze et al.
Experimental parasitology, 135(2), 331-336 (2013-08-07)
Trypanosomosis has been associated with immunosuppression, anemia and oxidative damage while selenium possesses both immunostimulatory and antioxidative effects. This study was designed to assess the effect of dietary selenium supplementation on parasitemia, anemia, survival pattern and serum protein profiles of...
Hitoshi Ueno et al.
Biological & pharmaceutical bulletin, 37(8), 1352-1358 (2014-08-05)
Although supplementation with the selenocompound, sodium selenite has been shown to stimulate the concanavalin A-induced T-cell mitogenic response, the mechanisms responsible remain unclear. This study was conducted to evaluate the relationships between the induction of apoptosis, formation of tumor necrosis...
Vivek Narayan et al.
The Journal of nutritional biochemistry, 26(2), 138-145 (2014-12-03)
Acetylation of histone and non-histone proteins by histone acetyltransferases plays a pivotal role in the expression of proinflammatory genes. Given the importance of dietary selenium in mitigating inflammation, we hypothesized that selenium supplementation may regulate inflammatory gene expression at the...
Fabiola Rusolo et al.
Molecules (Basel, Switzerland), 18(3), 2549-2562 (2013-02-28)
The need to explore new alternative therapeutic strategies and chemoprevention methods for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays a critical role in physiological processes, and is used in cancer chemoprevention. The aim of this...
Ibtissem Ben Amara et al.
Environmental toxicology, 28(11), 630-643 (2011-09-03)
There is considerable interest in the study of free radical-mediated damage to biological systems due to pesticide exposure. However, there is a lack of consensus as to which determinations are best used to quantify future risks arising from xenobiotic exposure...
Jianjun Hu et al.
Human molecular genetics, 23(17), 4663-4673 (2014-04-25)
Filamin B (FlnB) is an actin-binding protein thought to transduce signals from various membrane receptors and intracellular proteins onto the actin cytoskeleton. Formin1 (Fmn1) is an actin-nucleating protein, implicated in actin assembly and intracellular signaling. Human mutations in FLNB cause...
Lei Rao et al.
International journal of nanomedicine, 9, 4819-4828 (2014-11-08)
As a potential protein therapeutic for type 2 diabetes mellitus (T2DM), BAY 55-9837 is limited by poor stability and a very short half-life in vivo. The purpose of this study was to construct a novel nanostructured biomaterial by conjugating BAY...
C Linscheid et al.
Placenta, 36(8), 832-838 (2015-06-23)
Maternal T-cells reactive towards paternally inherited fetal minor histocompatibility antigens are expanded during pregnancy. Placental trophoblast cells express at least four fetal antigens, including human minor histocompatibility antigen 1 (HA-1). We investigated oxygen as a potential regulator of HA-1 and...
Yongchao Li et al.
American journal of physiology. Cell physiology, 309(8), C532-C540 (2015-08-14)
Loss of oligodendrocytes as the result of central nervous system disease causes demyelination that impairs axon function. Effective directional migration of endogenous or grafted oligodendrocyte precursor cells (OPCs) to a lesion is crucial in the neural remyelination process. In this...
Urška Kristan et al.
Biological trace element research, 151(2), 240-246 (2012-12-18)
The distribution and speciation of selenium (Se) in freshwater fish (muscle and liver tissue) from lakes in Argentina was investigated. Three introduced species, brown trout (Salmo trutta), rainbow trout (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis), and one native species...
Hatice Baş et al.
Environmental toxicology and pharmacology, 39(3), 1019-1026 (2015-04-12)
The adverse effects of lead nitrate (LN) and the preventive role of sodium selenite were investigated in diabetic and non-diabetic rat blood by measuring trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP), malondialdehyde (MDA) levels and activities of...
Maren Lindner et al.
Brain : a journal of neurology, 138(Pt 7), 1875-1893 (2015-04-25)
Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the underlying cellular and molecular mechanisms remain poorly understood. We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of...
Qingjie Wang et al.
American journal of physiology. Heart and circulatory physiology, 309(11), H1894-H1903 (2015-10-11)
Epoxyeicosatrienoic acids (EETs) have beneficial effects on cardiovascular disease. Soluble epoxide hydrolase (sEH) metabolizes EETs to less active diols, thus diminishing their biological activity. sEH inhibitors can suppress the progression of atherosclerotic lesions in animal models. However, the regulation of...
Takeshi Imai et al.
Bioscience, biotechnology, and biochemistry, 78(8), 1376-1380 (2014-08-19)
Selenite is a selenium source for selenoprotein biosynthesis in mammalian cells. Although previous studies have suggested the involvement of glutathione (GSH) and/or thioredoxin reductase in selenite metabolism, intracellular selenite metabolism remains largely unknown. Here, we report that GSH depletion did...
Laetitia Asser et al.
Molecular and cellular endocrinology, 395(1-2), 1-9 (2014-07-25)
Glucocorticoid receptor (GR), a ubiquitous transcriptional factor, regulates target gene expression upon activation by glucocorticoids, notably cortisol, a corticosteroid hormone synthesized in the adrenal cortex. We thus hypothesized that both GR and cortisol might be involved in the regulation of...
Małgorzata Anita Bryszewska et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 29, 91-98 (2014-12-04)
In this study, we investigate the type and quantity of selenium compounds in fish and marine organisms, using ion-pair reversed phase LC–ICP-MS, developed and applied for the analysis of Atlantic cod, Atlantic salmon, Greenland halibut, Atlantic herring, blue mussel, common...
Alper Yazici et al.
Cutaneous and ocular toxicology, 33(4), 327-332 (2014-03-20)
The aim of this study is to evaluate the retinal toxicity of cisplatin and neuroprotective effect of selenium in cisplatin-related retinal toxicity. Eighteen adult Wistar-Albino rats were divided into three groups. Group 1 (n = 6) received intraperitoneal (i.p.) injection...
Terry W Moody et al.
Journal of molecular neuroscience : MN, 56(3), 663-672 (2015-03-13)
Cholecystokinin (CCK) receptors are G-protein coupled receptors (GPCR) which are present on lung cancer cells. CCK-8 stimulates the proliferation of lung cancer cells, whereas the CCK2R receptor antagonist CI-988 inhibits proliferation. GPCR for some gastrointestinal hormones/neurotransmitters mediate lung cancer growth...
Rooban B Nahomi et al.
The Biochemical journal, 465(1), 115-125 (2014-10-22)
Previous studies have identified peptides in the 'crystallin-domain' of the small heat-shock protein (sHSP) α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in heat-shock protein Hsp20 (G71HFSVLLDVKHFSPEEIAVK91) and Hsp27 (D93RWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin also have robust...
Simon Godin et al.
Journal of agricultural and food chemistry, 63(28), 6484-6492 (2015-07-15)
Two forms of selenium (Se) supplementation of fish feeds were compared in two different basal diets. A 12-week feeding trial was performed with rainbow trout fry using either a plant-based or a fish meal-based diet. Se yeast and selenite were...
Francisco Javier Rodriguez-Jimenez et al.
International journal of molecular sciences, 16(11), 26608-26618 (2015-11-13)
Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role of Connexin 50 (Cx50) in cell fate modulation of adult spinal cord derived neural precursors located...
A Dalle Zotte et al.
Poultry science, 94(9), 2114-2123 (2015-07-29)
This study investigated the impact of 2 coccidiosis control systems (vaccine vs anticoccidial) and 2 feeding plans (standard energy vs low energy content, the latter supplemented with threonine and enzymes in the second half of the production cycle) on white...
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