Showing 1-30 of 105 resultados for "SML0370"
Guangfeng Zhao et al.
Scientific reports, 5, 7647-7647 (2015-01-07)
Chemotherapy treatment in women can frequently cause damage to the ovaries, which may lead to primary ovarian insufficiency (POI). In this study, we assessed the preventative effects of hyaluronic acid (HA) in immunosuppressive drug-induced POI-like rat models and investigated the...
A Valiani et al.
Bratislavske lekarske listy, 118(10), 591-597 (2017-12-05)
Due to very sluggish turnover at the molecular and cellular level, the healing of chondral damages has been considered difficult. In the current study, the effects of the Kartogenin, a small heterocyclic molecule on chondrogenic differentiation of stem cells was...
Shang Li et al.
EBioMedicine, 36, 539-552 (2018-10-08)
The ovulatory dysfunction mechanisms underlying polycystic ovary syndrome (PCOS) are not completely understood. And the roles of EPHA7 and EPHA7-regulated pathway factors in the pathogenesis of anovulation remain to be elucidated. We used human granulosa cells (hGCs) of PCOS and...
Xin Huang et al.
Reproductive biology and endocrinology : RB&E, 16(1), 73-73 (2018-08-05)
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. An lncRNA, namely, Prader-Willi region nonprotein coding RNA 2 (PWRN2), was up-regulated in the cumulus cells of patients with PCOS. However, the molecular mechanism of PWRN2 in...
Astrud R Tuck et al.
Endocrine, 48(2), 686-695 (2014-07-06)
Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothesised that KITL gene expression...
Jianying Zhang et al.
Bone research, 2 (2014-11-25)
Tendon-bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartogenin (KGN), a biocompound, to...
Seeun Park et al.
Environmental toxicology and pharmacology, 38(3), 845-851 (2014-12-03)
Simazine is a suspected endocrine disruptor and the second most commonly detected pesticide in surface and groundwater worldwide. We evaluated the toxicity of simazine in female mouse offspring with in utero and lactational exposure to the agent. Pregnant mice were...
Yulin Li et al.
Journal of cellular physiology, 234(5), 7435-7447 (2018-12-24)
Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in child-bearing-age women. It is characterized by ovulation dysfunction, polycystic ovaries, and hyperandrogenism. Inflammation is likely to be a crucial contributor to the pathogenesis of PCOS. However...
Binbin Wang et al.
Human reproduction (Oxford, England), 32(10), 2138-2146 (2017-09-25)
Does a novel heterozygous KHDRBS1 variant, identified using whole-exome sequencing (WES) in two patients with primary ovarian insufficiency (POI) in a pedigree, cause defects in mRNA alternative splicing? The heterozygous variant of KHDRBS1 was confirmed to cause defects in alternative...
Mariarosaria Lang-Muritano et al.
The Journal of clinical endocrinology and metabolism, 103(10), 3748-3756 (2018-08-17)
Estrogen resistance due to mutations in the estrogen receptor α gene (ESR1) has been described in men and women and is characterized by osteoporosis, delayed bone age and continuous growth in adulthood, and delayed puberty and multiple ovarian cysts in...
Yuan Ni et al.
The Journal of endocrinology (2019-07-26)
Prenatal ethanol exposure (PEE) adversely affects the offspring reproductive system. We aimed to confirm the susceptibility to premature ovarian insufficiency (POI) in female PEE offspring and elucidate its intrauterine programming mechanism. The pregnant Wistar female rats were intragastrically administered with...
Justyna Gogola et al.
Toxicology in vitro : an international journal published in association with BIBRA, 65, 104769-104769 (2020-01-11)
Insulin-like growth factor-1 (IGF1) is a hormone involved in cell proliferation. We previously showed that IGF1 directly stimulates cell proliferation in granulosa cell tumors (GCTs). Estrogen regulates IGF1 expression in several reproductive organs including the uterus and ovaries. This study...
Yoshitaka Imamichi et al.
Scientific reports, 7(1), 8374-8374 (2017-08-23)
Diethylstilbestrol (DES), a strong estrogenic compound, is well-known to affect the reproductive system. In this study, we investigated the effects of DES administration on gonadotropin levels and ovarian steroidogenesis in prepubertal rats. DES treatment acutely reduced serum LH levels, followed...
Jun-Peng Dong et al.
Cell death & disease, 10(11), 791-791 (2019-10-19)
Granulosa cells (GCs) play a critical role in driving the formation of ovarian follicles and building the cumulus-oocyte complex surrounding the ovum. We are particularly interested in assessing oocyte quality by examining the detailed gene expression profiles of human cumulus...
Po-Han Lin et al.
Biomolecules, 9(8) (2019-08-03)
Women with polycystic ovary syndrome (PCOS) have been reported to have an elevated serum advanced glycation end product (AGE) level. However, the effect of AGEs on the pathophysiological ovarian granulosa cells of PCOS is still unclear. In this study, five...
Dean Wang et al.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 34(9), 2579-2587 (2018-07-25)
To investigate the use of kartogenin (KGN) in augmenting healing of the repaired enthesis after rotator cuff repair in a murine model. Seventy-two C57BL/6 wild-type mice underwent unilateral detachment and transosseous repair of the supraspinatus tendon augmented with either fibrin...
Hanyong Jin et al.
PloS one, 11(7), e0159112-e0159112 (2016-07-16)
Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve. However, the mechanisms of AMH regulation...
Pei Xu et al.
The Journal of clinical endocrinology and metabolism, 104(7), 2547-2560 (2018-11-27)
Women with obesity usually need larger doses of FSH for ovarian stimulation, resulting in poor outcomes; however, the mechanism is still unclear. To investigate the molecular regulation of FSH receptor (FSHR) expression associated with obesity. Case-control study to improve in...
Chuan-Jin Yu et al.
Biochemical and biophysical research communications (2020-02-23)
Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by hyperandrogenism, polycystic ovaries, and anovulation. Previous studies have revealed that androgen receptors (ARs) are strongly associated with hyperandrogenism and abnormalities in folliculogenesis in patients with PCOS. However, the...
Gengxiang Wu et al.
Molecular and cellular endocrinology, 506, 110760-110760 (2020-02-20)
Long non-coding RNAs (lncRNAs) play a vital role in the progression of many human diseases. The aim of this study is to explore the relationship between lncRNA-ovarian cancer associated 1 (Lnc-OC1) and PCOS. In this study, we found that Lnc-OC1...
Yinxia Li et al.
Animal reproduction science, 196, 19-27 (2018-07-19)
The Nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene encodes a nuclear receptor that regulates the transcription of genes involved in steroidogenesis, follicular development and female fertility. Little, however, is known about the relationship of this gene with...
Chanwei Jia et al.
Gene, 744, 144591-144591 (2020-03-30)
Polycystic ovary syndrome (PCOS) is a kind of endocrine disease among women across the global. Recently, many researches have reported circular RNAs can act as significant molecular biomarkers for diseases, especially in tumors. Several Circular RNAs are reported to be...
Yuping Wu et al.
Reproductive biology and endocrinology : RB&E, 16(1), 85-85 (2018-09-05)
Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, although some studies have indicated the involvement of endoplasmic reticulum stress (ERS). The aim...
He Huang et al.
The American journal of sports medicine, 45(14), 3289-3297 (2017-09-02)
The meniscus is one of the most commonly injured parts of the body, and meniscal healing is difficult. Kartogenin (KGN) induces tendon stem cells (TSCs) to differentiate into cartilage cells in vitro and form meniscus-like tissue in vivo. A damaged...
Kevin Yu et al.
PloS one, 14(6), e0217211-e0217211 (2019-06-07)
Fetal development is thought to proceed in a sterile environment. Recent reports of the presence of bacterial DNA in human placenta, the transfer of live bacteria from mother to fetus after hypoxia in the pregnant sheep, and the presence of...
Feng Liu et al.
Stem cell research & therapy, 10(1), 201-201 (2019-07-10)
The meniscus tear is one of the most common knee injuries particularly seen in athletes and aging populations. Subchondral bone sclerosis, irreparable joint damage, and the early onset of osteoarthritis make the injured meniscus heal difficultly. The study was performed...
Shanling Yi et al.
American journal of physiology. Endocrinology and metabolism, 319(1), E91-E101 (2020-04-29)
Mitochondrial injury in granulosa cells is associated with the pathogenesis of polycystic ovary syndrome (PCOS). However, the protective effects of melatonin against mitochondrial injury in the granulosa cells of PCOS remain unclear. In this study, decreased mitochondrial membrane potential and...
Yuxia Song et al.
Molecular and cellular endocrinology, 494, 110478-110478 (2019-06-08)
MicroRNAs (miRNAs) are a group of negative regulators of gene expression that function at the posttranscriptional level. Dysregulation of miRNAs is involved in many pathophysiological processes, including polycystic ovary syndrome (PCOS). In this study, we first detected the expression levels...
Kai Zhu et al.
Reproduction (Cambridge, England), 155(6), 505-514 (2018-04-08)
Polycystic ovary syndrome, a common condition characterized by endocrine dysfunction, menstrual irregularity, anovulation and polycystic ovaries, affects 5-7% of reproductive-age women. RAB5B, which is identified by a genome-wide association study as a risk locus for this syndrome, encodes a small...
Photo-cross-linked scaffold with kartogenin-encapsulated nanoparticles for cartilage regeneration
Shi D, et al.
ACS Nano, 10(1), 1292-1299 (2016)

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