Showing 1-11 of 11 resultados for "T0557"
Salma Alavi et al.
Cell, 181(7), 1533-1546 (2020-07-08)
The gut microbiome is the resident microbial community of the gastrointestinal tract. This community is highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal pathogens is poorly understood. Using transplantation of human microbiomes into several animal models...
Susanne Naumann et al.
Nutrients, 11(6) (2019-06-28)
Dietary fibres are reported to interact with bile acids, preventing their reabsorption and promoting their excretion into the colon. We used a method based on in vitro digestion, dialysis, and kinetic analysis to investigate how dietary fibre enriched food ingredients...
Marc J Tol et al.
Autophagy, 14(3), 437-449 (2018-02-20)
In recent years, the lysosome has emerged as a highly dynamic, transcriptionally regulated organelle that is integral to nutrient-sensing and metabolic rewiring. This is coordinated by a lysosome-to-nucleus signaling nexus in which MTORC1 controls the subcellular distribution of the microphthalmia-transcription...
Kalinne Kelly Lima Gadelha et al.
Experimental physiology, 104(2), 199-208 (2018-12-19)
What is the central question of this study? Is the responsiveness of isolated segments of the rat oesophagus to contractile or relaxant stimuli susceptible to acute luminal exposure of the oesophagus to an acid solution that contains pepsin and bile...
Stefanie Mühlfeld et al.
Hepatology (Baltimore, Md.), 56(6), 2387-2397 (2012-07-19)
The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcellular localization of Ntcp was...
Kai Zheng et al.
Molecular nutrition & food research, 64(14), e1901231-e1901231 (2020-06-02)
The development of novel compounds that trigger non-apoptotic cell death may represent alternative therapeutic strategies for esophageal squamous cell carcinoma (ESCC) treatment. Cellular senescence suppresses tumorigenesis by halting the proliferation of tumor cells, implying the induction of senescence as a...
Emanuel Berger et al.
Biochemical and biophysical research communications, 409(4), 610-615 (2011-05-25)
Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to...
Amal Salhi et al.
Biochimie, 169, 106-120 (2019-07-10)
Porcine pancreatic extracts (PPE), also named pancreatin, are commonly used as a global source of pancreatic enzymes for enzyme replacement therapy in patients with exocrine pancreatic insufficiency. They are considered as a good substitute of human pancreatic enzymes and they...
Susan A Joyce et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(20), 7421-7426 (2014-05-07)
Alterations in the gastrointestinal microbiota have been implicated in obesity in mice and humans, but the key microbial functions influencing host energy metabolism and adiposity remain to be determined. Despite an increased understanding of the genetic content of the gastrointestinal...
Daniel Steil et al.
Journal of lipid research, 56(12), 2322-2336 (2015-10-16)
Shiga toxins (Stxs) are produced by enterohemorrhagic Escherichia coli (EHEC), which cause human infections with an often fatal outcome. Vero cell lines, derived from African green monkey kidney, represent the gold standard for determining the cytotoxic effects of Stxs. Despite...
Vishal Singh et al.
Cell, 175(3), 679-694 (2018-10-20)
Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet...

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