Merck
Search Within
Applied Filters:
Keyword:'t3559'
Showing 1-30 of 177 results for "

t3559

" within Papers
Sort by Relevance
Yanhua Rao et al.
PloS one, 9(12), e114087-e114087 (2014-12-11)
Primary cilia are specialized, acetylated microtubule-based signaling processes. Cilium assembly is activated by cellular quiescence and requires reconfiguration of microtubules, the actin cytoskeleton, and vesicular trafficking machinery. How these components are coordinated to activate ciliogenesis remains unknown. Here we identify
Pauline C Conroy et al.
Cell cycle (Georgetown, Tex.), 11(20), 3769-3778 (2012-10-17)
Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a wide range of human diseases. Centrosomes
Wei Zhao et al.
The Journal of cell biology, 212(7), 829-843 (2016-03-24)
Faithful chromosome segregation with bipolar spindle formation is critical for the maintenance of genomic stability. Perturbation of this process often leads to severe mitotic failure, contributing to tumorigenesis. MLL5 has been demonstrated to play vital roles in cell cycle progression
In Keol Baek et al.
Cytoskeleton (Hoboken, N.J.), 74(1), 18-28 (2016-12-10)
Mammalian cells are capable of de novo centriole formation after the removal of existing centrioles. This suggests that de novo centriole assembly is repressed in normally duplicating cells to maintain a constant number of centrioles in the cells. However, neither
Involvement of centrosome amplification in radiation-induced mitotic catastrophe.
Dodson, et al.
Cell Cycle, 6, 364-370 (2020)
Nam-Gyun Kim et al.
The Journal of cell biology, 210(3), 503-515 (2015-07-29)
The Hippo pathway is involved in the regulation of contact inhibition of proliferation and responses to various physical and chemical stimuli. Recently, several upstream negative regulators of Hippo signaling, including epidermal growth factor receptor ligands and lysophosphatidic acid, have been
Thomas D Manes et al.
Arteriosclerosis, thrombosis, and vascular biology, 36(9), 1910-1918 (2016-07-23)
Circulating human T effector memory cell (TEM) recognition of nonself MHC (major histocompatibility complex) molecules on allograft endothelial cells can initiate graft rejection despite elimination of professional antigen-presenting cells necessary for naive T-cell activation. Our previous studies of CD4 TEM
Melissa C Humbert et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(48), 19691-19696 (2012-11-15)
Mutations affecting ciliary components cause a series of related genetic disorders in humans, including nephronophthisis (NPHP), Joubert syndrome (JBTS), Meckel-Gruber syndrome (MKS), and Bardet-Biedl syndrome (BBS), which are collectively termed "ciliopathies." Recent protein-protein interaction studies combined with genetic analyses revealed
Yuanyuan Li et al.
Journal of the American Society of Nephrology : JASN, 27(12), 3628-3638 (2016-05-08)
The gene for ADP ribosylation factor-like GTPase 13B (Arl13b) encodes a small GTPase essential for cilia biogenesis in multiple model organisms. Inactivation of arl13b in zebrafish leads to a number of phenotypes indicative of defective cilia, including cystic kidneys. In
Annett Stange et al.
Journal of virology, 82(20), 9858-9869 (2008-08-08)
Glycoproteins of several viruses have the capacity to induce release of noninfectious, capsidless particulate structures containing only the viral glycoprotein. Such structures are often called subviral particles (SVP). Foamy viruses (FVs), a special type of retroviruses with a replication strategy
Haining Zhou et al.
Nature communications, 7, 10151-10151 (2016-01-09)
The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1-Mad2 is crucial for SAC activation. However, the mechanism by which Mad1-Mad2 accumulation
Fatima Sedjaï et al.
Journal of cell science, 123(Pt 14), 2391-2401 (2010-06-17)
Cilia and flagella are evolutionary conserved organelles that generate fluid movement and locomotion, and play roles in chemosensation, mechanosensation and intracellular signalling. In complex organisms, cilia are highly diversified, which allows them to perform various functions; however, they retain a
Eduarda Dráberová et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(5), 1828-1846 (2017-01-26)
γ-Tubulins are highly conserved members of the tubulin superfamily essential for microtubule nucleation. Humans possess 2 γ-tubulin genes. It is thought that γ-tubulin-1 represents a ubiquitous isotype, whereas γ-tubulin-2 is found predominantly in the brain, where it may be endowed
Raz Ben-Yair et al.
Development (Cambridge, England), 138(19), 4155-4166 (2011-08-20)
The plane of cell divisions is pivotal for differential fate acquisition. Dermomyotome development provides an excellent system with which to investigate the link between these processes. In the central sheet of the early dermomyotome, single epithelial cells divide with a
Haining Zhou et al.
BMC biology, 17(1), 73-73 (2019-09-16)
Spindle microtubule organization, regulated by microtubule-associated proteins, is critical for cell division. Proper organization of kinetochore fiber (K-fiber), connecting spindle poles and kinetochores, is a prerequisite for precise chromosomal alignment and faithful genetic material transmission. However, the mechanisms of K-fiber
M Ciciarello et al.
The Journal of biological chemistry, 276(22), 19205-19213 (2001-05-29)
Growing evidence indicates a central role for p53 in mediating cell cycle arrest in response to mitotic spindle defects so as to prevent rereplication in cells in which the mitotic division has failed. Here we report that a transient inhibition
Hsiao-Hui Kuo et al.
Cell division, 16(1), 8-8 (2021-12-20)
Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) and allow HSP expression during mitosis.
Alejandro Urdiciain et al.
Biology, 10(6) (2021-06-03)
Glioblastoma multiforme, the most common type of malignant brain tumor as well as the most aggressive one, lacks an effective therapy. Glioblastoma presents overexpression of mesenchymal markers Snail, Slug, and N-Cadherin and of the autophagic marker p62. Glioblastoma cell lines
Long Liu et al.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, 13(4), 212-220 (2020-03-11)
In birds, the female is heterogametic (ZW) and the male homogametic (ZZ). The small W chromosome comprises only 28 protein coding genes (homologues to Z chromosome counterparts) and a number of repeat regions. Here, we report our analysis of one
Yetunde Adesanya Ogungbenro et al.
The Journal of cell biology, 217(4), 1205-1215 (2018-02-15)
The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNTROB in hTERT-RPE1 cells and observed an increased frequency of monocentriolar and acentriolar cells. Using a
Szilard Szikora et al.
Journal of cell science, 126(Pt 1), 254-262 (2012-10-19)
Nuclei wriggle in the cells of the follicle epithelium of the Drosophila pre-vitellogenic egg primordia. Although similar phenomena have been reported for a number of cultured cell types and some neurons in the zebrafish embryo, the mechanism and importance of
Gen Shiratsuchi et al.
Journal of cell science, 124(Pt 17), 2964-2975 (2011-09-01)
Centriole duplication occurs once per cell cycle through the assembly of daughter centrioles on the side wall of pre-existing centrioles. Little is known about the molecules involved in the assembly of new centrioles. Here, we identify CRC70 as a Chlamydomonas
Akihito Inoko et al.
The Journal of cell biology, 197(3), 391-405 (2012-04-25)
The primary cilium is an antenna-like organelle that modulates differentiation, sensory functions, and signal transduction. After cilia are disassembled at the G0/G1 transition, formation of cilia is strictly inhibited in proliferating cells. However, the mechanisms of this inhibition are unknown.
Nirmal Dutta et al.
Biology open, 5(9), 1283-1289 (2016-08-06)
RPGR (retinitis pigmentosa GTPase regulator) is a ciliary protein associated with several forms of inherited retinal degenerative diseases. PDE6D is a ubiquitously expressed prenyl-binding protein and involved in ciliary targeting of prenylated proteins. The current working model for the RPGR
Jason Ioannidis et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(10) (2021-03-05)
In birds, males are the homogametic sex (ZZ) and females the heterogametic sex (ZW). Primary sex determination is thought to depend on a sex chromosome gene dosage mechanism, and the most likely sex determinant is the Z chromosome gene Doublesex
Marsha C Lampi et al.
PloS one, 11(1), e0147033-e0147033 (2016-01-14)
Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors whose pleiotropic effects include disrupting small
Henderika M J Hut et al.
Molecular biology of the cell, 14(5), 1993-2004 (2003-06-13)
A well-established function of centrosomes is their role in accomplishing a successful mitosis that gives rise to a pair of identical daughter cells. We recently showed that DNA replication defects and DNA damage in Drosophila embryos trigger centrosomal changes, but
Zhe Zhang et al.
Cancer research, 74(22), 6635-6647 (2014-09-26)
Prostate cancer is thought to be driven by oxidative stress, lipid metabolism, androgen receptor (AR) signaling, and activation of the PI3K-AKT-mTOR pathway, but it is uncertain how they may become coordinated during progression to castration-resistant disease that remains incurable. The
Qi Wang et al.
Molecular and cellular biology, 22(10), 3450-3459 (2002-04-25)
Human Polo-like kinase 3 (Plk3, previously termed Prk or Fnk) is involved in regulation of cell cycle progression through the M phase (B. Ouyang, H. Pan, L. Lu, J. Li, P. Stambrook, B. Li, and W. Dai, J. Biol. Chem.
Anne-Marie Flanagan et al.
Molecular biology of the cell, 28(6), 736-745 (2017-01-20)
Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker made up of rootletin filaments anchored to the
Page 1 of 6
Page 1 of 6