Showing 1-30 of 227 resultados for "T5192"
Dong Hyun Kim et al.
Cell death & disease, 10(8), 570-570 (2019-07-31)
The initiation of centrosome duplication is regulated by the Plk4/STIL/hsSAS-6 axis; however, the involvement of other centrosomal proteins in this process remains unclear. In this study, we demonstrate that Cep131 physically interacts with Plk4 following phosphorylation of residues S21 and...
Stanislav Vinopal et al.
PloS one, 7(1), e29919-e29919 (2012-01-12)
γ-Tubulin is the key protein for microtubule nucleation. Duplication of the γ-tubulin gene occurred several times during evolution, and in mammals γ-tubulin genes encode proteins which share ∼97% sequence identity. Previous analysis of Tubg1 and Tubg2 knock-out mice has suggested...
Thomas Juan et al.
Nature communications, 9(1), 1942-1942 (2018-05-18)
The establishment of left-right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including...
Chae-ryun Yi et al.
Journal of virology, 82(11), 5307-5315 (2008-03-28)
Abelson murine leukemia virus (Ab-MLV) arose from a recombination between gag sequences in Moloney MLV (Mo-MLV) and the c-abl proto-oncogene. The v-Abl oncoprotein encoded by Ab-MLV contains MA, p12, and a portion of CA sequences derived from the gag gene...
Davor Lessel et al.
The Journal of clinical investigation, 127(10), 3598-3608 (2017-08-29)
The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin ligase MDM2 via an autoregulatory feedback loop. In addition to its well-established role in tumorigenesis, p53 has also been associated...
Menuka Karki et al.
Nature communications, 8, 15803-15803 (2017-06-14)
The spindle assembly checkpoint (SAC) delays mitotic progression until all sister chromatid pairs achieve bi-orientation, and while the SAC can maintain mitotic arrest for extended periods, moderate delays in mitotic progression have significant effects on the resulting daughter cells. Here...
Kim Brint Pedersen et al.
Biochimica et biophysica acta, 1829(11), 1225-1235 (2013-10-09)
Pancreatic angiotensin-converting enzyme 2 (ACE2) has previously been shown to be critical for maintaining glycemia and β-cell function. Efforts to maintain or increase ACE2 expression in pancreatic β-cells might therefore have therapeutic potential for treating diabetes. In our study, we...
Sarah Croessmann et al.
Breast cancer research and treatment, 162(3), 451-464 (2017-02-13)
The combined contributions of oncogenes and tumor suppressor genes toward carcinogenesis remain poorly understood. Elucidation of cancer gene cooperativity can provide new insights leading to more effective use of therapies. We used somatic cell genome editing to introduce singly and...
Hua Deng et al.
Molecular biology of the cell, 21(19), 3304-3316 (2010-08-06)
The somatic muscles of Drosophila develop in a complex pattern that is repeated in each embryonic hemi-segment. During early development, progenitor cells fuse to form a syncytial muscle, which further differentiates via expression of muscle-specific factors that induce specific responses...
Robert Fragoza et al.
Nature communications, 10(1), 4141-4141 (2019-09-14)
Each human genome carries tens of thousands of coding variants. The extent to which this variation is functional and the mechanisms by which they exert their influence remains largely unexplored. To address this gap, we leverage the ExAC database of...
Shohei Yamamoto et al.
Biology open, 10(3) (2021-03-05)
The deuterosome is a non-membranous organelle involved in large-scale centriole amplification during multiciliogenesis. Deuterosomes are specifically assembled during the process of multiciliogenesis. However, the molecular mechanisms underlying deuterosome formation are poorly understood. In this study, we investigated the molecular properties...
The actin-binding and bundling protein, EPLIN, is required for cytokinesis.
Chircop, et al.
Cell Cycle, 8, 757-764 (2020)
Asher Castiel et al.
BMC cancer, 11, 412-412 (2011-09-29)
Cells of most human cancers have supernumerary centrosomes. To enable an accurate chromosome segregation and cell division, these cells developed a yet unresolved molecular mechanism, clustering their extra centrosomes at two poles, thereby mimicking mitosis in normal cells. Failure of...
A Toledo et al.
Brain structure & function, 224(6), 2121-2142 (2019-06-06)
Neurofibromatosis type 2 (NF2) patients are prone to develop glial-derived tumors in the peripheral and central nervous system (CNS). The Nf2 gene product -Merlin is not only expressed in glia, but also in neurons of the CNS, where its function...
Francisco Javier Rodriguez-Jimenez et al.
Frontiers in cell and developmental biology, 7, 334-334 (2020-01-11)
The neurogenic niche of the subventricular zone (SVZ) in adult brain tissue takes the form of a pinwheel-like cytoarchitectural structure, with mono-ciliated astrocytes displaying neural stem cell (NSC) characteristics present in the core surrounded by ciliated ependymal cells. For the...
Miju Kim et al.
Nature communications, 5, 5370-5370 (2014-11-05)
Primary cilia are microtubule-based organelles that protrude from polarized epithelial cells. Although many structural and trafficking molecules that regulate ciliogenesis have been discovered, signalling proteins are not well defined. Here we show that the MST1/2-SAV1 complex, a core component of...
Nicole L Umberger et al.
Molecular biology of the cell, 26(2), 350-358 (2014-11-14)
Primary cilia are built and maintained by intraflagellar transport (IFT), whereby the two IFT complexes, IFTA and IFTB, carry cargo via kinesin and dynein motors for anterograde and retrograde transport, respectively. Many signaling pathways, including platelet- derived growth factor (PDGF)-AA/αα...
Khaled Aziz et al.
The Journal of clinical investigation, 128(8), 3517-3534 (2018-07-24)
A homozygous truncating frameshift mutation in CEP57 (CEP57T/T) has been identified in a subset of mosaic-variegated aneuploidy (MVA) patients; however, the physiological roles of the centrosome-associated protein CEP57 that contribute to disease are unknown. To investigate these, we have generated...
Melissa J Bennett et al.
Cell cycle (Georgetown, Tex.), 11(16), 3045-3054 (2012-08-09)
Laulimalide is a natural product that has strong taxoid-like properties but binds to a distinct site on β-tubulin in the microtubule (MT) lattice. At elevated concentrations, it generates MTs that are resistant to depolymerization, and it induces a conformational state...
A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.
Castiel A
BMC Cancer, 11:412 (2011)
Z Matijasevic et al.
Oncogenesis, 5(10), e262-e262 (2016-10-04)
The MDMX (MDM4) oncogene is amplified or overexpressed in a significant percentage of human tumors. MDMX is thought to function as an oncoprotein by binding p53 tumor suppressor protein to inhibit p53-mediated transcription, and by complexing with MDM2 oncoprotein to...
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.
Cassimeris L and Morabito J
Molecular Biology of the Cell, 15(4), 1580-1590 (2004)
Monique C M Balemans et al.
Human molecular genetics, 22(5), 852-866 (2012-11-24)
Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that catalyzes mono- and dimethylation of histone H3 lysine 9, thereby epigenetically regulating transcription. Kleefstra syndrome (KS), is caused by haploinsufficiency of the EHMT1 gene, and is an example of...
Julia Vulprecht et al.
Journal of cell science, 125(Pt 5), 1353-1362 (2012-02-22)
Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a few proteins including PLK4, CPAP (CENPJ), SAS6, CEP192, CEP152 and CEP135 have thus far been identified to be required for centriole duplication. STIL (SCL/TAL1 interrupting locus...
Lourdes Valdés-Sánchez et al.
Human molecular genetics, 22(8), 1507-1515 (2013-01-09)
Ataxia-telangiectasia and Rad3 (ATR), a sensor of DNA damage, is associated with the regulation and control of cell division. ATR deficit is known to cause Seckel syndrome, characterized by severe proportionate short stature and microcephaly. We used a mouse model...
Michiru Nishita et al.
Scientific reports, 7(1), 1-1 (2017-01-28)
Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability...
Jana Rohožková et al.
Nucleus (Austin, Tex.), 10(1), 93-115 (2019-05-10)
During meiosis, homologous chromosomes undergo a dramatic movement in order to correctly align. This is a critical meiotic event but the molecular properties of this 'chromosomal dance' still remainunclear. We identified DEB-1 - an orthologue of mammalian vinculin - as...
Linda Viol et al.
The Journal of cell biology, 219(3) (2020-03-27)
Distal appendages (DAs) of the mother centriole are essential for the initial steps of ciliogenesis in G1/G0 phase of the cell cycle. DAs are released from centrosomes in mitosis by an undefined mechanism. Here, we show that specific DAs lose...
Galectin-8 Is Upregulated in Keratinocytes by IL-17A and Promotes Proliferation by Regulating Mitosis in Psoriasis.
Lo, et al.
The Journal of Investigative Dermatology, 141, 503-511 (2021)
Causes and consequences of gray matter heterotopia.
Watrin F
CNS Neuroscience & Therapeutics, 21(2), 112-122 (2015)

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