Showing 1-30 of 56 resultados for "T8535"
Ulrich Valcourt et al.
Molecular biology of the cell, 16(4), 1987-2002 (2005-02-04)
Epithelial-mesenchymal transition (EMT) contributes to normal tissue patterning and carcinoma invasiveness. We show that transforming growth factor (TGF)-beta/activin members, but not bone morphogenetic protein (BMP) members, can induce EMT in normal human and mouse epithelial cells. EMT correlates with the...
Nobuhiro Ban et al.
The Journal of biological chemistry, 282(13), 9628-9634 (2007-02-03)
ABCA3 protein is expressed predominantly at the limiting membrane of the lamellar bodies in alveolar type II cells, and mutations in the ABCA3 gene cause lethal respiratory distress in newborn infants. To investigate the function of ABCA3 protein, we generated...
Pingxin Li et al.
Molecular and cellular biology, 28(15), 4745-4758 (2008-05-29)
Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this modification is reversed to repress the expression of p53 target genes is unclear. Here, we report that peptidylarginine deiminase 4, a histone citrullination enzyme...
Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria.
Jaglin XH
Nature Genetics, 41, 746-752 (2009)
Jürg P F Nüesch et al.
Virology, 331(1), 159-174 (2004-12-08)
During a productive infection, the prototype strain of parvovirus minute virus of mice (MVMp) induces dramatic morphological alterations to the fibroblast host cell A9, resulting in cell lysis and progeny virus release. In order to understand the mechanisms underlying these...
C Balaratnasingam et al.
Neuroscience, 177, 269-282 (2011-01-11)
Oligodendrocyte-derived myelin retards the ability of CNS axons to regenerate following transection. The intrinsic response of CNS axons to an axotomy insult may be vastly different in the absence of myelin. However, the paucity of adequate experimental models has limited...
Anne-Laure Durand et al.
International journal of molecular sciences, 21(17) (2020-09-04)
Osteoarthritis (OA) is a degenerative disease of the joints which is associated with an impaired production of the cartilage matrix by the chondrocytes. Here, we investigated the role of Lysine-Specific Demethylase-1 (LSD1), a chromatin remodeling enzyme whose role in articular...
Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2.
Copley CO
The Journal of Neuroscience, 33, 14001-14016 (2013)
A Banerjee et al.
The Journal of biological chemistry, 263(6), 3029-3034 (1988-02-25)
Mammalian brain tubulin consists of several isotypes of alpha and beta subunits that separate on polyacrylamide gels into three electrophoretic classes, designated alpha, beta 1, and beta 2. It has not been possible hitherto to resolve the different isotypes in...
ABCA3 as a Lipid Transporter in Pulmonary Surfactant Biogenesis
Ban N
The Journal of Biological Chemistry, 282, 9628-9634 (2007)
Hironao Nakayama et al.
The Journal of biological chemistry, 288(15), 10338-10348 (2013-02-23)
All members of the EGF family are produced as transmembrane precursors that are proteolytically processed into soluble forms by disintegrin and metalloproteinases (ADAMs) for autocrine/paracrine pathways. In turn, the ligand-activated EGF receptor (EGFR) induces the expression of EGF family members...
Andrea N Ladd et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 233(3), 783-793 (2005-04-15)
Cardiac troponin T (cTNT) exon 5 splicing is developmentally regulated such that it is included in embryonic but not adult heart. CUG-BP and ETR-3-like factor (CELF) proteins promote exon inclusion, whereas polypyrimidine tract binding protein (PTB) and muscleblind-like (MBNL) proteins...
Thyroid hormone regulates tubulin expression in mammalian liver. Effects of deleting thyroid hormone receptor-alpha or -beta.
Vallejo, et al.
American Journal of Physiology. Endocrinology and Metabolism, 289, E87-E94 (2006)
Han-Hsuan Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(27), 7325-7339 (2016-07-08)
Fragile X mental retardation protein (FMRP) is thought to regulate neuronal plasticity by limiting dendritic protein synthesis, but direct demonstration of a requirement for FMRP control of local protein synthesis during behavioral plasticity is lacking. Here we tested whether FMRP...
Gohar Ter-Avetisyan et al.
Frontiers in cellular neuroscience, 12, 153-153 (2018-07-03)
Bifurcation of axons from dorsal root ganglion (DRG) and cranial sensory ganglion (CSG) neurons is mediated by a cGMP-dependent signaling pathway composed of the ligand C-type natriuretic peptide (CNP), the receptor guanylyl cyclase Npr2 and the cGMP-dependent protein kinase I...
Cytoskeleton in action: Lissencephaly, a neuronal migration disorder
Moon HM
Wiley interdisciplinary reviews. Developmental biology, 2, 229-245 (2013)
Jeffrey K Huang et al.
BMC developmental biology, 7, 59-59 (2007-06-02)
Trigeminal nerves consist of ophthalmic, maxillary, and mandibular branches that project to distinct regions of the facial epidermis. In Xenopus embryos, the mandibular branch of the trigeminal nerve extends toward and innervates the cement gland in the anterior facial epithelium....
Caroline R McKeown et al.
The Journal of comparative neurology, 521(10), 2262-2278 (2012-12-15)
Nonmammalian vertebrates have a remarkable capacity to regenerate brain tissue in response to central nervous system (CNS) injury. Nevertheless, it is not clear whether animals recover lost function after injury or whether injury-induced cell proliferation mediates recovery. We address these...
Marcin Kowanetz et al.
The Journal of cell biology, 182(4), 655-662 (2008-08-30)
Signal transduction by transforming growth factor beta (TGFbeta) coordinates physiological responses in diverse cell types. TGFbeta signals via type I and type II receptor serine/threonine kinases and intracellular Smad proteins that regulate transcription. Strength and duration of TGFbeta signaling is...
Casey L Kilpatrick et al.
The Journal of biological chemistry, 291(53), 27371-27386 (2016-11-23)
The γ2 subunit of GABA type A receptors (GABAARs) is thought to be subject to palmitoylation by both Golgi-associated DHHC-type zinc finger protein (GODZ; also known as DHHC3) and its paralog Sertoli cell gene with a zinc finger domain-β (SERZ-β;...
Ayasa Nakamura et al.
PloS one, 14(1), e0210193-e0210193 (2019-01-11)
The human natural killer-1 (HNK-1) carbohydrate epitope, composed of a unique sulfated trisaccharide (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-R), is highly expressed during brain development and regulates higher brain function. However, it remains unclear which glycoprotein carries the HNK-1 epitope in the embryonic brain and...
Placido Illiano et al.
Biomolecules, 10(6) (2020-06-04)
The activity of the hypothalamus-pituitary-adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT Knockout (KO)...
Benoit M Meijer et al.
The Journal of biological chemistry, 292(19), 7784-7794 (2017-03-23)
Old long-lived proteins contain dehydroalanine (Dha) and dehydrobutyrine (Dhb), two amino acids engendered by dehydration of serines and threonines, respectively. Although these residues have a suspected role in protein cross-linking and aggregation, their direct implication has yet to be determined....
Lina Vardouli et al.
The Journal of biological chemistry, 280(12), 11448-11457 (2005-01-14)
Reorganization of the actin cytoskeleton in response to growth factor signaling, such as transforming growth factor beta (TGF-beta), controls cell adhesion, motility, and growth of diverse cell types. In Swiss3T3 fibroblasts, a widely used model for studies of actin reorganization...
Valentina A Kulichkova et al.
Oncotarget, 8(60), 102134-102149 (2017-12-20)
Proteasome-mediated proteolysis is important for many basic cellular processes. In addition to their functions in the cell, proteasomes have been found in physiological fluids of both healthy and diseased humans including cancer patients. Higher levels of these proteasomes are associated...
HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity.
Tarazona R
Journal of Immunology, 165, 6776-6782 (2000)
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 48(8), 3632-3644 (2007-07-27)
To investigate the axonal cytoskeleton changes occurring in the prelaminar region, lamina cribrosa, and postlaminar region of the porcine optic nerve after an acute increase in intraocular pressure (IOP) and whether this corresponds with axonal transport abnormalities. Six white Landrace...
Daniella L Muller et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 148-154 (2005-03-18)
Induction of the transcription factor deltaFosB was studied to examine neurochemical adaptations produced by repeated opiate administration. The mechanism of this induction was also investigated. The 35- to 37-kDa isoforms of deltaFosB, also referred to as the chronic Fras, were...
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 49(3), 986-999 (2008-03-11)
To study the time-dependent effects of elevated intraocular pressure (IOP) on axonal transport and cytoskeleton proteins in the porcine optic nerve head. Fifteen pigs were used for this study. Rhodamine-beta-isothiocyanate was injected into the vitreous of each eye to study...
Marcin Kowanetz et al.
Molecular and cellular biology, 24(10), 4241-4254 (2004-05-04)
Transforming growth factors beta (TGF-betas) inhibit growth of epithelial cells and induce differentiation changes, such as epithelial-mesenchymal transition (EMT). On the other hand, bone morphogenetic proteins (BMPs) weakly affect epithelial cell growth and do not induce EMT. Smad4 transmits signals...

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