Showing 1-30 of 59 resultados for "


Casey L Kilpatrick et al.
The Journal of biological chemistry, 291(53), 27371-27386 (2016-11-23)
The γ2 subunit of GABA type A receptors (GABAARs) is thought to be subject to palmitoylation by both Golgi-associated DHHC-type zinc finger protein (GODZ; also known as DHHC3) and its paralog Sertoli cell gene with a zinc finger domain-β (SERZ-β;...
Ayasa Nakamura et al.
PloS one, 14(1), e0210193-e0210193 (2019-01-11)
The human natural killer-1 (HNK-1) carbohydrate epitope, composed of a unique sulfated trisaccharide (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-R), is highly expressed during brain development and regulates higher brain function. However, it remains unclear which glycoprotein carries the HNK-1 epitope in the embryonic brain and...
Lina Vardouli et al.
The Journal of biological chemistry, 280(12), 11448-11457 (2005-01-14)
Reorganization of the actin cytoskeleton in response to growth factor signaling, such as transforming growth factor beta (TGF-beta), controls cell adhesion, motility, and growth of diverse cell types. In Swiss3T3 fibroblasts, a widely used model for studies of actin reorganization...
Placido Illiano et al.
Biomolecules, 10(6) (2020-06-04)
The activity of the hypothalamus-pituitary-adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT Knockout (KO)...
Valentina A Kulichkova et al.
Oncotarget, 8(60), 102134-102149 (2017-12-20)
Proteasome-mediated proteolysis is important for many basic cellular processes. In addition to their functions in the cell, proteasomes have been found in physiological fluids of both healthy and diseased humans including cancer patients. Higher levels of these proteasomes are associated...
Benoit M Meijer et al.
The Journal of biological chemistry, 292(19), 7784-7794 (2017-03-23)
Old long-lived proteins contain dehydroalanine (Dha) and dehydrobutyrine (Dhb), two amino acids engendered by dehydration of serines and threonines, respectively. Although these residues have a suspected role in protein cross-linking and aggregation, their direct implication has yet to be determined....
Cytoskeleton in action: Lissencephaly, a neuronal migration disorder
Moon HM
Wiley interdisciplinary reviews. Developmental biology, 2, 229-245 (2013)
Caroline R McKeown et al.
The Journal of comparative neurology, 521(10), 2262-2278 (2012-12-15)
Nonmammalian vertebrates have a remarkable capacity to regenerate brain tissue in response to central nervous system (CNS) injury. Nevertheless, it is not clear whether animals recover lost function after injury or whether injury-induced cell proliferation mediates recovery. We address these...
Jeffrey K Huang et al.
BMC developmental biology, 7, 59-59 (2007-06-02)
Trigeminal nerves consist of ophthalmic, maxillary, and mandibular branches that project to distinct regions of the facial epidermis. In Xenopus embryos, the mandibular branch of the trigeminal nerve extends toward and innervates the cement gland in the anterior facial epithelium....
Marcin Kowanetz et al.
The Journal of cell biology, 182(4), 655-662 (2008-08-30)
Signal transduction by transforming growth factor beta (TGFbeta) coordinates physiological responses in diverse cell types. TGFbeta signals via type I and type II receptor serine/threonine kinases and intracellular Smad proteins that regulate transcription. Strength and duration of TGFbeta signaling is...
HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity.
Tarazona R
Journal of Immunology, 165, 6776-6782 (2000)
Han-Hsuan Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(27), 7325-7339 (2016-07-08)
Fragile X mental retardation protein (FMRP) is thought to regulate neuronal plasticity by limiting dendritic protein synthesis, but direct demonstration of a requirement for FMRP control of local protein synthesis during behavioral plasticity is lacking. Here we tested whether FMRP...
Gohar Ter-Avetisyan et al.
Frontiers in cellular neuroscience, 12, 153-153 (2018-07-03)
Bifurcation of axons from dorsal root ganglion (DRG) and cranial sensory ganglion (CSG) neurons is mediated by a cGMP-dependent signaling pathway composed of the ligand C-type natriuretic peptide (CNP), the receptor guanylyl cyclase Npr2 and the cGMP-dependent protein kinase I...
Thyroid hormone regulates tubulin expression in mammalian liver. Effects of deleting thyroid hormone receptor-alpha or -beta.
Vallejo, et al.
American Journal of Physiology. Endocrinology and Metabolism, 289, E87-E94 (2006)
Nobuhiro Ban et al.
The Journal of biological chemistry, 282(13), 9628-9634 (2007-02-03)
ABCA3 protein is expressed predominantly at the limiting membrane of the lamellar bodies in alveolar type II cells, and mutations in the ABCA3 gene cause lethal respiratory distress in newborn infants. To investigate the function of ABCA3 protein, we generated...
Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria.
Jaglin XH
Nature Genetics, 41, 746-752 (2009)
Ulrich Valcourt et al.
Molecular biology of the cell, 16(4), 1987-2002 (2005-02-04)
Epithelial-mesenchymal transition (EMT) contributes to normal tissue patterning and carcinoma invasiveness. We show that transforming growth factor (TGF)-beta/activin members, but not bone morphogenetic protein (BMP) members, can induce EMT in normal human and mouse epithelial cells. EMT correlates with the...
Pingxin Li et al.
Molecular and cellular biology, 28(15), 4745-4758 (2008-05-29)
Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this modification is reversed to repress the expression of p53 target genes is unclear. Here, we report that peptidylarginine deiminase 4, a histone citrullination enzyme...
Andrea N Ladd et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 233(3), 783-793 (2005-04-15)
Cardiac troponin T (cTNT) exon 5 splicing is developmentally regulated such that it is included in embryonic but not adult heart. CUG-BP and ETR-3-like factor (CELF) proteins promote exon inclusion, whereas polypyrimidine tract binding protein (PTB) and muscleblind-like (MBNL) proteins...
C Balaratnasingam et al.
Neuroscience, 177, 269-282 (2011-01-11)
Oligodendrocyte-derived myelin retards the ability of CNS axons to regenerate following transection. The intrinsic response of CNS axons to an axotomy insult may be vastly different in the absence of myelin. However, the paucity of adequate experimental models has limited...
Jürg P F Nüesch et al.
Virology, 331(1), 159-174 (2004-12-08)
During a productive infection, the prototype strain of parvovirus minute virus of mice (MVMp) induces dramatic morphological alterations to the fibroblast host cell A9, resulting in cell lysis and progeny virus release. In order to understand the mechanisms underlying these...
Hironao Nakayama et al.
The Journal of biological chemistry, 288(15), 10338-10348 (2013-02-23)
All members of the EGF family are produced as transmembrane precursors that are proteolytically processed into soluble forms by disintegrin and metalloproteinases (ADAMs) for autocrine/paracrine pathways. In turn, the ligand-activated EGF receptor (EGFR) induces the expression of EGF family members...
A Banerjee et al.
The Journal of biological chemistry, 263(6), 3029-3034 (1988-02-25)
Mammalian brain tubulin consists of several isotypes of alpha and beta subunits that separate on polyacrylamide gels into three electrophoretic classes, designated alpha, beta 1, and beta 2. It has not been possible hitherto to resolve the different isotypes in...
Jing Wang et al.
Biochemical and biophysical research communications, 419(2), 262-267 (2012-02-22)
The 3'-untranslated regions (3'-UTRs) of growth-associated protein 43 (GAP-43), which is crucial for neural development and axonal regeneration, are highly conserved among vertebrates. Previous studies in mammals have identified one U-rich cis element within GAP-43 3'-UTR and several trans factors...
ABCA3 as a Lipid Transporter in Pulmonary Surfactant Biogenesis
Ban N
The Journal of Biological Chemistry, 282, 9628-9634 (2007)
Anne-Laure Durand et al.
International journal of molecular sciences, 21(17) (2020-09-04)
Osteoarthritis (OA) is a degenerative disease of the joints which is associated with an impaired production of the cartilage matrix by the chondrocytes. Here, we investigated the role of Lysine-Specific Demethylase-1 (LSD1), a chromatin remodeling enzyme whose role in articular...
Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2.
Copley CO
The Journal of Neuroscience, 33, 14001-14016 (2013)
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).
Basciano PA
British Journal of Haematology, 160, 237-243 (2013)
Lina Vardouli et al.
The FEBS journal, 275(16), 4074-4087 (2008-07-18)
In previous studies, we have demonstrated that RhoA/B-dependent signaling regulates TGFbeta-induced rapid actin reorganization in Swiss 3T3 fibroblasts. Here we report that TGFbeta regulates long-term actin remodeling by increasing the steady-state mRNA levels of the RhoB gene in mouse Swiss...
Catherine O Copley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(35), 14001-14016 (2013-08-30)
The distinctive planar polarity of auditory hair cells is evident in the polarized organization of the stereociliary bundle. Mutations in the core planar cell polarity gene Van Gogh-like 2 (Vangl2) result in hair cells that fail to properly orient their...