Showing 1-30 of 418 resultados for "V8137"
Koji Matsuhisa et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 865-880 (2020-01-10)
Intramembrane cleavage of transmembrane proteins is a fundamental cellular process to produce important signals that elicit biological responses. These proteolytic events are known as regulated intramembrane proteolysis (RIP). ATF6 and BBF2H7 are transmembrane basic leucine zipper transcription factors and are...
Stephanie R Monticelli et al.
Journal of virology, 94(7) (2020-01-17)
Orthopoxviruses produce two, antigenically distinct, infectious enveloped virions termed intracellular mature virions and extracellular virions. Extracellular virions are required for cell-to-cell spread and pathogenesis. Specific to the extracellular virion membrane, glycoproteins A33, A34, and B5 are highly conserved among orthopoxviruses...
Xinrong Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(1), 761-770 (2019-12-25)
Small RNAs (sRNAs) associate with Argonaute (AGO) proteins in effector complexes, termed RNA-induced silencing complexes (RISCs), which regulate complementary transcripts by translation inhibition and/or RNA degradation. In the unicellular alga Chlamydomonas, several metazoans, and land plants, emerging evidence indicates that...
K Vanessa Carias et al.
PloS one, 15(4), e0230874-e0230874 (2020-04-22)
MAGEL2 encodes the L2 member of the MAGE (melanoma antigen) protein family. Protein truncating mutations in MAGEL2 cause Schaaf-Yang syndrome, and MAGEL2 is one of a small set of genes deleted in Prader-Willi syndrome. Excessive daytime sleepiness, night-time or early...
Grzegorz Rebowski et al.
Science advances, 6(15), eaay8793-eaay8793 (2020-04-15)
About 80% of human proteins are amino-terminally acetylated (Nt-acetylated) by one of seven Nt-acetyltransferases (NATs). Actin, the most abundant protein in the cytoplasm, has its own dedicated NAT, NAA80, which acts posttranslationally and affects cytoskeleton assembly and cell motility. Here...
Claire E McKellar et al.
eLife, 9 (2020-06-26)
We describe the anatomy of all the primary motor neurons in the fly proboscis and characterize their contributions to its diverse reaching movements. Pairing this behavior with the wealth of Drosophila's genetic tools offers the possibility to study motor control...
Shamol Saha et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(29), 9210-9218 (2009-07-25)
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant familial Parkinson's disease. We generated lines of Caenorhabditis elegans expressing neuronally directed human LRRK2. Expressing human LRRK2 increased nematode survival in response to rotenone or paraquat, which are agents that cause...
Junghee Jin et al.
Molecular psychiatry, 25(5), 1035-1049 (2019-02-15)
Genetic polymorphisms of the L-type voltage-gated calcium channel (VGCC) are associated with psychiatric disorders including major depressive disorder. Alterations of S100A10 (p11) level are also implicated in the etiology of major depressive disorder. However, the existence of an endogenous regulator...
Guang-Yu Bai et al.
Development (Cambridge, England), 147(8) (2020-04-29)
Mammalian oocytes are arrested at G2/prophase of the first meiosis. After a hormone surge, oocytes resume meiosis, undergoing germinal vesicle breakdown (GVBD). This process is regulated by Cdk1/cyclin B1. Here, we report that Mis12 is required for G2/M transition by...
Jing Li et al.
Frontiers in physiology, 11, 708-708 (2020-07-17)
Background: Cardiac bridging integrator 1 (cBIN1) organizes transverse tubule (t-tubule) membrane calcium handling microdomains required for normal beat-to-beat contractility. cBIN1 is transcriptionally reduced in heart failure (HF). We recently found that cBIN1 pretreatment can limit HF development in stressed mice....
Ravit Gabay Yehezkely et al.
Developmental cell, 53(4), 406-417 (2020-05-04)
Integration of extracellular matrix (ECM)-derived cues into transcriptional programs is essential primarily in rapidly morphing environments, such as regenerating tissues. Here, we demonstrate that lysyl oxidase (Lox), known for its ECM-modifying activities, primarily collagen crosslinking, also directly regulates transcription factor...
LGR5 constitutively activates NF-?B signaling to regulate the growth of intestinal crypts.
Lai, et al.
Faseb Journal, 34, 15605-15620 (2021)
Conserved roles of chromatin remodellers in cohesin loading onto chromatin.
Mu?oz, et al.
Current Genetics, 66, 951-956 (2021)
Chi-Chung Wang et al.
Cancers, 11(12) (2019-12-19)
Metastasis is a predominant cause of cancer death and the major challenge in treating lung adenocarcinoma (LADC). Therefore, exploring new metastasis-related genes and their action mechanisms may provide new insights for developing a new combative approach to treat lung cancer....
John Cerrone et al.
Drug metabolism and disposition: the biological fate of chemicals, 48(7), 544-552 (2020-05-01)
Several cytochrome P450 enzymes are known to be down-regulated by nitric oxide (NO). CYP2A6 is responsible for the metabolism of nicotine and several other xenobiotics, but its susceptibility to down-regulation by NO has not been reported. To address this question...
Sayantanee Paul et al.
Molecular biology of the cell, 31(4), 235-243 (2020-01-09)
The extracellular signal-regulated kinase (ERK) pathway is an essential component of developmental signaling in metazoans. Previous models of pathway activation suggested that dissociation of activated dually phosphorylated ERK (dpERK) from MAPK/ERK kinase (MEK), a kinase that phosphorylates ERK, and other...
Salik Hussain et al.
eLife, 9 (2020-01-29)
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or danger-associated molecular patterns. TLR4, the prototypic receptor...
Tomáš Venit et al.
Scientific reports, 6, 30864-30864 (2016-08-03)
Plasma membrane tension is an important feature that determines the cell shape and influences processes such as cell motility, spreading, endocytosis and exocytosis. Unconventional class 1 myosins are potent regulators of plasma membrane tension because they physically link the plasma...
Kyun Ha Kim et al.
BMC complementary medicine and therapies, 20(1), 40-40 (2020-02-09)
Guettarda speciosa is mainly found in tropical areas in Asia. Although G. speciosa is traditionally used to treat some of the inflammatory disorders, the experimental evidence supporting the anti-inflammatory effect of G. speciosa is limited. Here, we sought to obtain...
Martin L Rennie et al.
EMBO reports, 21(7), e50133-e50133 (2020-06-09)
The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms of replication stress. A key step in the FA pathway is the monoubiquitination of each...
John L Ubels et al.
The CRISPR journal, 3(4), 284-298 (2020-08-25)
Humans carrying homozygous loss-of-function mutations in the Wnt co-receptor, low-density lipoprotein receptor-related protein 5 (LRP5), develop osteoporosis and a defective retinal vasculature known as familial exudative vitreoretinopathy (FEVR) due to disruption of the Wnt signaling pathway. The purpose of this...
Zhong Yao et al.
Nature communications, 11(1), 2440-2440 (2020-05-18)
Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal...
XueQiao Liu et al.
Journal of virology, 94(11) (2020-03-28)
Interferon alpha (IFN-α) and IFN-β are type I IFNs that are induced by virus infection and are important in the host's innate antiviral response. EBV infection activates multiple cell signaling pathways, resulting in the production of type I IFN which...

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