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Makiko Shimizu et al.
Molecular genetics and metabolism, 107(3), 330-334 (2012-07-24)
Loss-of-function mutations of flavin-containing monooxygenase 3 (FMO3), the enzyme responsible for trimethylamine N-oxygenation, cause the inherited disorder trimethylaminuria, or fish odor syndrome. The aim of this study was to further investigate the inter-individual variations of FMO3 activity in a Japanese...
Wei Feng et al.
Scientific reports, 5, 17422-17422 (2015-12-04)
Photothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes...
Nancy D Epsky et al.
Journal of economic entomology, 105(2), 471-479 (2012-05-23)
Tests were conducted that evaluated efficacy of wax matrix bait stations for Ceratitis capitata (Wiedemann) adults in Guatemala. Bait stations were exposed to outdoor conditions to determine effect of weathering on longevity as indicated by bait station age. Results of...
Keitaro Yokoyama et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 17(6), 1032-1036 (2002-05-29)
Pteridine metabolism is impaired in the uraemic state. This may affect cardiovascular function and contribute to malnutrition. We wished to clarify further the impact of impaired pteridine metabolism. Using the HPLC method, the plasma concentrations of endogenous pteridines were determined...
Moritz Butscheid et al.
Naunyn-Schmiedeberg's archives of pharmacology, 375(6), 401-406 (2007-06-16)
Advanced glycation end products (AGEs), e.g., carboxymethyllysine (CML) or imidazolone are involved in several age-related disorders. Concerning their accumulation, the importance of hepatic and renal function is controversially discussed. To test whether impairment of hepatic or renal function will affect...
W Doehner et al.
American heart journal, 141(5), 792-799 (2001-04-26)
Chronic heart failure (CHF) is a hyperuricemic state, and capillary endothelium is the predominant site of xanthine oxidase in the vasculature. Upregulated xanthine oxidase activity (through production of toxic free radicals) may contribute to impaired regulation of vascular tone in...
Marcus A Bain et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 21(5), 1300-1304 (2006-01-13)
Trimethylamine (TMA) is a short-chain tertiary aliphatic amine that is derived from the diet either directly from the consumption of foods high in TMA or by the intake of food high in precursors to TMA, such as trimethylamine-N-oxide (TMNO), choline...
C K Chao et al.
The Journal of nutritional biochemistry, 1(2), 89-97 (1990-02-01)
Choline is a component of the normal diet, and when humans ingest large amounts they excrete trimethylamine (which can impart a fishy body odor). In the presence of nitrite, trimethylamine can be converted to dimethylnitrosamine, a potent carcinogen. Bacteria in...
Marcus A Bain et al.
Current drug metabolism, 6(3), 227-240 (2005-06-25)
Trimethylamine (TMA) is a volatile tertiary aliphatic amine that is derived from the diet either directly from the consumption of foods containing TMA, or by the intake of food containing precursors to TMA such as trimethylamine-N-oxide (TMNO), choline and L-carnitine....
J Wang et al.
Poultry science, 91(9), 2221-2228 (2012-08-23)
To evaluate the effect of flavin-containing monooxygenase 3 (FMO3) genotype and dietary choline supplementation on trimethylamine (TMA) metabolism in HyLine Brown laying hens, a 3 × 2 two-factorial arrangement was employed with FMO3 genotypes (AA, AT, and TT) and dietary...
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and...
Marilyn C Erickson et al.
Journal of food protection, 78(12), 2156-2169 (2015-11-29)
Microbial spoilage of salmon occurs during extended refrigerated storage and is often accompanied by unpleasant aromas. When spoilage is detected, it is assumed that consumers will reject the product for consumption. Because sensory panels of trained individuals or consumers are...
Hyeryeong Jeon et al.
Macromolecular rapid communications, 33(11), 972-976 (2012-04-12)
Polydiacetylenes (PDAs), a family of conjugated polymers, are very intriguing materials in several aspects. Especially, the stimulus-induced apparent blue-to-red transition of the PDAs has led to the development of a variety of PDA-based chemosensors. In the current work, we synthesized...
Jack D Sobel et al.
European journal of obstetrics, gynecology, and reproductive biology, 163(1), 81-84 (2012-04-24)
To compare diagnosis of bacterial vaginosis according to the Amsel criteria with measurement by ion mobility spectrometry (IMS) of the biogenic amines that are present in vaginal discharge fluid. Duplicate samples of vaginal fluid were collected from 115 unselected and...
B C Sweatman et al.
Journal of pharmaceutical and biomedical analysis, 11(8), 651-664 (1993-08-01)
Extensive assignments of resonances in the 600 MHz 1H-NMR spectra of cerebrospinal fluid are reported. These have been achieved by the measurement of a combination of two-dimensional experiments comprising homonuclear J-resolved, COSY45, and double-quantum filtered COSY (DQCOSY) spectra. By these...
Joshua Boateng et al.
International journal of biological macromolecules, 79, 63-71 (2015-05-06)
Lyophilized wafers comprising sodium alginate (SA) and gelatin (GE) (0/100, 75/25, 50/50, 25/75, 0/100 SA/GE, respectively) with silver sulfadiazine (SSD, 0.1% w/w) have been developed for potential application on infected chronic wounds. Polymer-drug interactions and physical form were characterized by...
Converging on a mechanism for choline degradation.
Christopher J Thibodeaux et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(52), 21184-21185 (2012-12-18)
Seung Hwan Lee et al.
Biosensors & bioelectronics, 71, 179-185 (2015-04-25)
A bioelectronic nose based on a novel microfluidic system (μBN) was fabricated to detect gaseous trimethylamine (TMA) in real-time. Single-walled carbon nanotube-field effect transistors (SWNT-FETs) were functionalized with olfactory receptor-derived peptides (ORPs) that can recognize the TMA molecules. The ORP-coated...
Yong Yu et al.
Nature communications, 3, 1252-1252 (2012-12-06)
Polycystic kidney disease (PKD) family proteins associate with transient receptor potential (TRP) channel family proteins to form functionally important complexes. PKD proteins differ from known ion channel-forming proteins and are generally thought to act as membrane receptors. Here we find...
Abhishek Bhattacharya et al.
Cell, 176(5), 1174-1189 (2019-01-29)
The specific patterns and functional properties of electrical synapses of a nervous system are defined by the neuron-specific complement of electrical synapse constituents. We systematically examined the molecular composition of the electrical connectome of the nematode C. elegans through a genome-...
A S K Dzik-Jurasz et al.
The British journal of radiology, 76(907), 483-486 (2003-07-15)
The sampling of gall bladder bile for analytical studies remains an invasive procedure. We demonstrate the application of the non-invasive methodology of (1)H-MR spectroscopy to the qualitative and quantitative assessment of human gall bladder bile in vivo. Spectral profiles in...
Md Mahmudur Rahman et al.
Journal of chromatography. A, 1314, 241-248 (2013-09-28)
An experimental technique based on sorbent tube-thermal desorption-gas chromatography (ST-TD-GC) was investigated for the simultaneous determination of a cluster of eight volatile odorants (propionic acid, n-butyric acid, i-valeric acid, n-valeric acid, trimethylamine, phenol, indole, and skatole) and a reference compound...
D O McGregor et al.
Kidney international, 59(6), 2267-2272 (2001-05-31)
Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown. Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine...
D S Raj et al.
Blood purification, 18(2), 97-102 (2000-06-06)
The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD....
Xishan Guo et al.
The Analyst, 138(18), 5265-5273 (2013-07-19)
A novel gas sensor based on composite films of poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) and single-walled carbon nanotubes (SWCNTs) was fabricated for the detection of fishy trimethylamine (TMA) vapor. The SWCNTs were functionalized by O2 plasma treatment to improve their solubility in the...
Hyung-Sik Woo et al.
Nanotechnology, 23(24), 245501-245501 (2012-05-30)
Highly selective and sensitive detection of trimethylamine (TMA) was achieved by the decoration of discrete p-type Cr(2)O(3) nanoparticles on n-type ZnO nanowire (NW) networks. Semielliptical Cr(2)O(3) nanoparticles with lateral widths of 3-8 nm were deposited on ZnO NWs by the...
David Leys et al.
Biochemical Society symposium, (71)(71), 1-14 (2005-03-22)
TMADH (trimethylamine dehydrogenase) is a complex iron-sulphur flavoprotein that forms a soluble electron-transfer complex with ETF (electron-transferring flavoprotein). The mechanism of electron transfer between TMADH and ETF has been studied using stopped-flow kinetic and mutagenesis methods, and more recently by...
Two-cationic 2-methylbenzothiazole derivatives as green light absorbed sensitizers in initiation of free radical polymerization.
Janina Kabatc et al.
Colloid and polymer science, 293(7), 1865-1876 (2015-07-07)
Okhil K Nag et al.
Journal of pharmaceutical sciences, 104(1), 114-123 (2014-11-14)
We report the synthesis of an acyl-anchored superhydrophilic polymer (SHP) for external surface modification of liposome surface. N¹-(2-aminoethyl)-N⁴-hexadecyl-2-tetradecylsuccinamide conjugated with SHP (HDAS-SHP) was synthesized and used for modifying the liposome surface. Unlike polyethylene glycol (PEG)-phospholipids, which are commonly used for...
Genetic polymorphism of trimethylamine N-oxidation.
R Ayesh et al.
Pharmacology & therapeutics, 45(3), 387-401 (1990-01-01)
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