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Janneke Hilderink et al.
Journal of cellular and molecular medicine, 19(8), 1836-1846 (2015-03-18)
Clinical islet transplantation is a promising treatment for patients with type 1 diabetes. However, pancreatic islets vary in size and shape affecting their survival and function after transplantation because of mass transport limitations. To reduce diffusion restrictions and improve islet
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
Eva Herzog et al.
Anesthesiology, 122(2), 387-398 (2014-11-25)
Edoxaban is an oral, selective direct factor Xa inhibitor approved in Japan for venous thromboembolism prevention after orthopedic surgery. Data are lacking regarding reversal strategies for edoxaban; this study assessed whether four-factor prothrombin complex concentrate (Beriplex/Kcentra; CSL Behring GmbH, Marburg
Navid Adnani et al.
Marine drugs, 13(10), 6082-6098 (2015-09-26)
With respect to bacterial natural products, a significant outcome of the genomic era was that the biosynthetic potential in many microorganisms surpassed the number of compounds isolated under standard laboratory growth conditions, particularly among certain members in the phylum Actinobacteria.
John M Franck et al.
Progress in nuclear magnetic resonance spectroscopy, 74, 33-56 (2013-10-03)
Liquid state Overhauser effect Dynamic Nuclear Polarization (ODNP) has experienced a recent resurgence of interest. The ODNP technique described here relies on the double resonance of electron spin resonance (ESR) at the most common, i.e. X-band (∼10GHz), frequency and ¹H
Egor V Verbitskiy et al.
Journal of fluorescence, 25(3), 763-775 (2015-03-31)
Novel donor-π-acceptor dyes bearing the pyrimidine unit as an electron-withdrawing group have been synthesized by using combination of two processes, based on the microwave-assisted Suzuki cross-coupling reaction and nucleophilic aromatic substitution of hydrogen. Spectral properties of the obtained dyes in
Felix Grases et al.
The Journal of urology, 194(3), 812-819 (2015-03-31)
The main aim of the current study was to evaluate the effectiveness of mixtures of magnesium, citrate and phytate as calcium oxalate crystallization inhibitors. A turbidimetric assay in synthetic urine was performed to obtain induction times for calcium oxalate crystallization
Sandeep Kumar et al.
Journal of nanoscience and nanotechnology, 14(6), 4331-4336 (2014-04-18)
Carbon nanotubes (CNTs) are attracting increasing research interest as promising adsorbents for harmful cations, anions, and other organic and inorganic impurities present in natural sources of water. This study examined the feasibility of removing Rhodamine B dye from aqueous solutions
Laure-Anais Vincent et al.
Fundamental & clinical pharmacology, 29(2), 164-177 (2015-01-21)
On account of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) remains a therapeutic challenge. This study focuses on acquired resistance to vinca alkaloids (VAs) using VA-resistant MM cell lines (CAL1R-VCR, CAL1R-VDS, and
Xuesong Guo et al.
Journal of environmental sciences (China), 25(4), 645-651 (2013-08-09)
In the Orbal oxidation ditch, denitrification is primarily accomplished in the outer channel. However, the detailed characteristics of the flow field and dissolved oxygen (DO) distribution in the outer channel are not well understood. Therefore, in this study, the flow
Richard J Flannery et al.
American journal of physiology. Renal physiology, 309(8), F697-F707 (2015-08-21)
Defects in primary cilia lead to a variety of human diseases. One of these, polycystic kidney disease, can be caused by defects in a Ca²⁺-gated ion channel (TRPP2) found on the cilium. Other ciliary functions also contribute to cystogenesis, and
Diana Adliene et al.
Radiation protection dosimetry, 165(1-4), 406-409 (2015-03-31)
Evaluation of the new lead-free optically transparent nanocomposites is provided in this paper along with the introduction to their fabrication technologies and the results of investigation of their X-ray attenuating and optical properties before and after their exposure to high
Helen M Ashmead et al.
Biopolymers, 103(5), 260-270 (2014-11-25)
Proteins hold great promise in forming complex nanoscale structures which could be used in the development of new nanomaterials, devices, biosensors, electronics, and pharmaceuticals. The potential to produce nanomaterials from proteins is well supported by the numerous examples of self-assembling
Xiao Ma et al.
Molecular medicine reports, 11(2), 1228-1234 (2014-11-06)
Previous studies have suggested that hepatocyte apoptosis may be a fundamental underlying mechanism of liver injury and diseases, such as liver fibrosis. Relaxin‑3 has been reported to have anti‑fibrotic actions in the heart and to attenuate isoproterenol‑induced myocardial injury; however
Stefan Wagner et al.
Bioorganic & medicinal chemistry, 23(12), 2839-2847 (2015-04-25)
Phosphopeptide mimetics containing the 4-phosphonocarbonyl phenylalanine (pcF) as a photo-active phosphotyrosine isoster are developed as potent, light-switchable inhibitors of the protein tyrosine phosphatase PTP1B. The photo-active inhibitors 6-10 are derived from phosphopeptide substrates and are prepared from the suitably protected
Shelly R H Pecorella et al.
American journal of physiology. Lung cellular and molecular physiology, 309(8), L857-L871 (2015-07-19)
The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here we examined whether CO breathing can be
Marlene Kaposi et al.
Dalton transactions (Cambridge, England : 2003), 44(36), 15976-15983 (2015-08-19)
Amino-functionalised metal-organic frameworks UiO-66 and -67 were post-synthetically modified with salicylaldehyde. A molybdenum complex was immobilised on the resulting materials. They were characterised by (13)C-MAS-NMR, XPS and PXRD to confirm immobilisation and stability. The immobilised complex is an active and
Marzena Medrek et al.
Acta poloniae pharmaceutica, 70(4), 659-665 (2013-08-08)
The fullerene C60 has chemical properties which seem to predestinate it to be effective transporter of drugs in biological system. To prove this, the DFT/B3LYP (6-31G*) calculations were performed especially in order to determine the structures and energies of the
Rebecca Klar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7600-7615 (2015-05-15)
Of the eight metabotropic glutamate (mGlu) receptor subtypes, only mGlu7 is expressed presynaptically at the Schaffer collateral (SC)-CA1 synapse in the hippocampus in adult animals. Coupled with the inhibitory effects of Group III mGlu receptor agonists on transmission at this
Stephan Blüml et al.
Arthritis research & therapy, 17, 230-230 (2015-08-27)
Autoreactive T cells are a central element in many systemic autoimmune diseases. The generation of these pathogenic T cells is instructed by antigen-presenting cells (APCs). However, signaling pathways in APCs that drive autoimmune diseases, such as rheumatoid arthritis, are not
Bulent Uludag et al.
The journal of adhesive dentistry, 16(6), 523-529 (2014-09-30)
To evaluate the microleakage of Cerec 3, IPS e.max Press, and Turkom-Cera inlays cemented with three self-adhesive resin cements. Ninety standardized class III MOD cavities were prepared in intact human mandibular third molars. Ceramic inlays were fabricated according to the
Claudia Stäubert et al.
Oncotarget, 6(23), 19706-19720 (2015-04-04)
Cancer cells exhibit characteristic changes in their metabolism with efforts being made to address them therapeutically. However, targeting metabolic enzymes as such is a major challenge due to their essentiality for normal proliferating cells. The most successful pharmaceutical targets are
Lena Neufeld et al.
International journal of pharmaceutics, 491(1-2), 170-179 (2015-06-28)
A new design for nanocomposite hydrogels based on cross-linked chitosan for the delivery of mesalamine is presented. To enhance drug loading in chitosan, the mineral montmorillonite was incorporated into the matrix. The exfoliated silica montmorillonite nanosheets form interactions with both
Daniel Garcia-Seco et al.
PloS one, 10(11), e0142639-e0142639 (2015-11-13)
Application of a plant growth promoting rhizobacterium (PGPR), Pseudomonas fluorescens N21.4, to roots of blackberries (Rubus sp.) is part of an optimised cultivation practice to improve yields and quality of fruit throughout the year in this important fruit crop. Blackberries
Mohammad Namavari et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(2), 168-176 (2014-10-04)
To develop novel positron emission tomography (PET) agents for visualization and therapy monitoring of bacterial infections. It is known that maltose and maltodextrins are energy sources for bacteria. Hence, (18)F-labelled maltose derivatives could be a valuable tool for imaging bacterial
F Paradis et al.
Journal of animal science, 93(7), 3331-3341 (2015-10-07)
In beef cattle, production feedstuffs are the largest variable input cost. Beef cattle also have a large carbon footprint, raising concern about their environmental impact. Unfortunately, only a small proportion of dietary energy is directed toward protein deposition and muscle
Els van Pamel et al.
Analytical and bioanalytical chemistry, 407(15), 4485-4494 (2015-03-31)
This study concerns a validated liquid chromatographic/tandem mass spectrometric (LC-MS/MS) multiresidue method for the simultaneous detection, identification, and quantitation of 15 nonsteroidal anti-inflammatory drugs (NSAIDs) in bovine meat and milk. The NSAIDs considered are carprofen, diclofenac, flufenamic acid, flunixin (5-hydroxyflunixin
Daniel J O'Sullivan et al.
BMC microbiology, 15, 266-266 (2015-11-19)
The aim of this study was to employ high-throughput DNA sequencing to assess the incidence of bacteria with biogenic amine (BA; histamine and tyramine) producing potential from among 10 different cheeses varieties. To facilitate this, a diagnostic approach using degenerate
Andrew M Novick et al.
Neuropharmacology, 97, 194-200 (2015-06-10)
Being bullied during adolescence is associated with later mental illnesses characterized by deficits in cognitive tasks mediated by prefrontal cortex (PFC) dopamine (DA). Social defeat of adolescent male rats, as a model of teenage bullying victimization, results in medial PFC
Ok Joo Lee et al.
Journal of biomedical nanotechnology, 10(7), 1294-1303 (2014-05-09)
Several auto- or alloplastic dermal substitutes have been used for full thickness skin defects. However, there is no ideal dermal substitute that is biocompatible and offers adequate mechanical properties and sufficient thickness and volume. Silk fibroin can be considered a
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