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x1126

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Katja Grabowski et al.
PloS one, 10(2), e0116807-e0116807 (2015-02-04)
Reactivation of fetal gene expression patterns has been implicated in common cardiac diseases in adult life including left ventricular (LV) hypertrophy (LVH) in arterial hypertension. Thus, increased wall stress and neurohumoral activation are discussed to induce the return to expression
M W Laschke et al.
European cells & materials, 28, 287-298 (2014-10-24)
Adipose tissue-derived microvascular fragments are promising vascularisation units for applications in the field of tissue engineering. Elderly patients are the major future target population of such applications due to an increasing human life expectancy. Therefore, we herein investigated the effect
Jisu Park et al.
PloS one, 10(11), e0141988-e0141988 (2015-11-05)
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells. Among the components of the chloroform extract, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol (DMPB) increased melanogenesis in
Mehran Dabaghian et al.
Antiviral research, 120, 23-31 (2015-05-20)
As the importance of virus-specific IgG2a and strong induction of Th1 type immune response for virus clearance was reported, conventional influenza vaccines induce a highly humoral immune response and fail to induce cytotoxic T-lymphocyte (CTL) immunity. Hence, in agreement with
Cagri T Unal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 853-863 (2015-01-16)
In addition to innervating the cerebral cortex, basal forebrain cholinergic (BFc) neurons send a dense projection to the basolateral nucleus of the amygdala (BLA). In this study, we investigated the effect of near physiological acetylcholine release on BLA neurons using
Yang Su et al.
Biochimica et biophysica acta, 1843(11), 2481-2491 (2014-07-09)
Excessive levels of the glycolysis metabolite methylglyoxal (MG) elicit enhanced expression of adhesion molecules which foster leukocyte-endothelial cell interactions. The signaling mechanisms involved remain elusive. To address this, we investigated the signal transduction of leukocyte- and endothelial-expressed phosphoinositide 3-kinase (PI3K)
Mariko Izumo et al.
eLife, 3 (2014-12-20)
In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout mice by using floxed Bmal1 and pan-neuronal Cre lines. The
Sarah Syeda et al.
Experimental neurology, 267, 1-12 (2015-03-01)
The injury inflammatory response mediated by the innate immune system is an important contributor to neurodegeneration in the central nervous system (CNS) and retina. A major branch of the innate immune system is regulated by the Toll-like receptors (TLRs), which
Ercan Malkoc et al.
Renal failure, 36(10), 1564-1569 (2014-09-23)
Extracorporeal shock wave lithotripsy (ESW) induces renal damage by excessive production of free oxygen radicals. Free Oxygen radicals cause cellular injury by inducing nicks in DNA. The enzyme poly(adenosine diphosphate-ribose) polymerase (PARP) involved in the process of repair of DNA
Tarık Akman et al.
Inflammation, 38(4), 1581-1588 (2015-02-18)
Cerebral ischemia is still one of the most important topics in neurosciences. Our study aimed to investigate the neuroprotective and anti-oxidant effects of glycyrrhizic acid on focal cerebral ischemia in rats. Twenty-four rats were divided equally into three groups. A
Philippe Foubert et al.
Cell transplantation, 24(7), 1343-1361 (2013-09-28)
Endothelial progenitor cell (EPC) transplantation has beneficial effects for therapeutic neovascularization. We therefore assessed the effect of a therapeutic strategy based on EPC administration in the healing of radiation-induced damage. To improve cell therapy for clinical use, we used pretreatment
HaeYong Kweon et al.
Biomaterials, 35(30), 8576-8584 (2014-07-16)
Grafted macromolecules often induce granuloma formation with foreign body giant cell (FBGC) infiltration, and this is the main reason for graft failure. Diacylglycerol kinase (DAGK) is an important intracellular mediator of FBGC formation in macrophages. In this study, 4-hexylresorcinol (4HR)
Antonio Frizziero et al.
Histology and histopathology, 30(9), 1079-1088 (2015-03-15)
Having previously demonstrated that detraining affects patellar tendon (PT) proteoglycan content and collagen fiber organization, we undertook the present study with two aims: to improve knowledge on the adaptation of PT and its enthesis to detraining from a histological and
Jung-Wan Choi et al.
The American journal of Chinese medicine, 43(1), 57-70 (2015-02-03)
This study was designed to determine the antinociceptive effect and related neuronal mechanism of electroacupuncture (EA) on paclitaxel (PTX)-induced neuropathic pain in mice. PTX (4 mg/kg, i.p.) was administered once a day for 5 consecutive days to induce neuropathic pain.
Irina Leonardi et al.
International journal of experimental pathology, 96(3), 151-162 (2015-02-27)
Trichuris suis ova (TSO) have shown promising results in the treatment of inflammatory bowel disease (IBD) but the mechanisms which underlies this therapeutic effect cannot be studied in mice and rats as T. suis fails to colonize the rodent intestine, whilst
Silvia Maestroni et al.
Acta ophthalmologica, 93(3), e218-e222 (2014-10-02)
To verify the effect of vasostatin-1 (VS-1), an anti-angiogenic fragment of chromogranin A, in the prevention of choroidal neovascularization (CNV) in an established mouse model of laser-induced ocular neovascularization. Bruch's membrane, the innermost layer of the choroid, was broken by
Guadalupe Delgado et al.
Thyroid : official journal of the American Thyroid Association, 25(3), 352-360 (2015-02-11)
Iodine is a crucial component of thyroid hormones, and several reports have shown that iodine per se is implicated in the physiopathology of other organs. Innovative ion chromatography detection following a four-step temperature ramp microwave digestion in 25-50 mM nitric acid
Kang-Mi Pang et al.
Bio-medical materials and engineering, 25(1), 25-38 (2015-01-15)
This study investigated the biologic properties of nano-hydroxyapatite (nHAp) using the rat calvarial defect, ectopic bone formation, and rabbit tibia implant installation models. Animals were divided into two groups: those implanted with nHAp, and negative controls (Collagen). Eight weeks after
Giovanna Lollo et al.
International journal of pharmaceutics, 495(2), 972-980 (2015-10-03)
In this work, multifunctional lipid nanocapsules (M-LNC) were designed to combine the activity of the cytotoxic drug paclitaxel (PTX) with the immunostimulant CpG. This nanosystem, consisting of modified lipid nanocapsules coated with a cationic polymeric shell composed of chitosan (CS)
Jun Yong Lee et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(1), 124-131 (2014-11-26)
To date, heat conduction from heat sources to tissue has been estimated by complex mathematical modeling. In the present study, we developed an intuitive in vitro skin burn model that illustrates heat conduction patterns inside the skin. This was composed
Jane-Fang Yu et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 45(4), 787-791 (2015-01-31)
The Formosan serow (Capricornis swinhoei) is a rare endemic species found in Taiwan. Few studies, including studies on anesthetic protocols, have been conducted on this species. This study evaluates the anesthetic effectiveness of intramuscular xylazine-ketamine and dexmedetomidine-ketamine on captive Formosan
Matej Kranjc et al.
Radiology, 274(1), 115-123 (2014-08-22)
To investigate the feasibility of magnetic resonance (MR) electric impedance tomography ( EIT electric impedance tomography ) technique for in situ monitoring of electric field distribution during in vivo electroporation of mouse tumors to predict reversibly electroporated tumor areas. All
Silvia Ribback et al.
Oncotarget, 6(15), 13036-13048 (2015-05-08)
Activation of the PI3K/AKT/mTOR pathway is a crucial molecular event in human clear cell renal cell carcinoma (ccRCC), and is also upregulated in diabetic nephropathy. In diabetic rats metabolic changes affect the renal distal tubular epithelium and lead to glycogen-storing
Piyanuch Wonganan et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1191-1201 (2014-04-26)
HC-04 cells were evaluated as an in vitro model for mechanistic study of changes in the function of hepatic CYP3A during virus infection. Similar to in vivo observations, infection with a first generation recombinant adenovirus significantly inhibited CYP3A4 catalytic activity
Melanie Lipp et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 252(6), 943-949 (2014-04-15)
The VEGF-A family plays a crucial role in the induction of pathological corneal neovascularization. The role of the different VEGF-A isoforms during lymphangiogenesis is only little-known. Current anti-angiogenic therapies in the eye and other organs inhibit all VEGF-A isoforms, and
F Salamanna et al.
Connective tissue research, 56(1), 35-43 (2014-10-22)
The purpose of this study was to investigate tenocyte mechanobiology after sudden-detraining and to examine the hypothesis that repeated peri-patellar injections of hyaluronic acid (HA) on detrained patellar tendon (PT) may reduce and limit detrained-associated damage in tenocytes. Twenty-four male
Tiberiu Popescu et al.
Life sciences, 117(2), 75-83 (2014-10-07)
The study investigated the effects of the combined treatment Parecoxib (Pcox) and 5,10,15,20-tetra-sulphonato-phenyl-porphyrin(TSPP)-mediated photodynamic therapy on Walker 256 carcinosarcoma. Five groups of male Wistar rats were used: the control group, treated with TSPP, group 2, irradiated 24 h thereafter, group
Hideaki Morita et al.
PloS one, 10(7), e0134226-e0134226 (2015-08-01)
IL-25, IL-33 and TSLP are produced predominantly by epithelial cells and are known to induce Th2-type cytokines. Th2-type cytokines are involved not only in host defense against nematodes, but also in the development of Th2-type allergic diseases. TSLP was reported
Takahiro Kondo et al.
Neuroscience research, 98, 35-44 (2015-06-21)
Using histological and electrophysiological methods, we identified the neuroanatomical properties of the common marmoset corticospinal tract (CST), which underlies hand/arm motor control. Biotinylated dextran amine (BDA) was injected into the primary motor cortex to anterogradely label CST axons in the
Francisco J Valiente-Soriano et al.
Investigative ophthalmology & visual science, 56(3), 1924-1936 (2015-02-28)
To study the responses of the general population of retinal ganglion cells (Brn3a(+)RGCs) versus the intrinsically photosensitive RGCs (melanopsin-expressing RGCs [m(+)RGCs]) to ocular hypertension (OHT), the effects of brain-derived neurotrophic factor (BDNF) on the survival of axonally intact and axonally
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