New diterpenoids and the bioactivity of Erythrophleum fordii.

Bioorganic & medicinal chemistry (2008-10-18)
Chuan-Chung Tsao, Yuh-Chiang Shen, Chung-Ren Su, Chia-Ying Li, Meei-Jen Liou, Nguyen-Xuan Dung, Tian-Shung Wu
RESUMEN

A phytochemical investigation of the leaves of Erythrophleum fordii Oliv. has led to the isolation of three new cassaine-type diterpenoids, erythrofordin A (1), erythrofordin B (2) and erythrofordin C (3), as well as a norcassaine diterpenoid with a novel skeleton, norerythrofordin A (4), and 27 known compounds (5-31). The structures of 1-4 were elucidated on the basis of spectroscopic analysis. Selected compounds from this plant were examined for anti-inflammatory activity. Taraxerol (16) displayed potent NO-reducing activity in microglial cells, and gallic acid (27) exhibited excellent DPPH radical-scavenging effects.

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Sigma-Aldrich
Gallic acid, 97.5-102.5% (titration)
Sigma-Aldrich
Gallic acid monohydrate, ACS reagent, ≥98.0%
Sigma-Aldrich
Gallic acid monohydrate, ≥99% (HPLC)
Sigma-Aldrich
Friedelin, technical grade