Merck

Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi.

Frontiers in microbiology (2021-02-09)
Chun-Lan Xie, Duo Zhang, Ting Lin, Zhi-Hui He, Qing-Xiang Yan, Qi Cai, Xiao-Kun Zhang, Xian-Wen Yang, Hai-Feng Chen
RESUMEN

Two new (1-2) and three known (3-5) sorbicillinoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580. Compounds 1 and 2, named sorbicatechols C and D, were two new hybrid dihydrosorbillinoids. Their structures were established mainly by spectroscopic analyses and electronic circular dichroism (ECD) calculations. All five isolates were tested for antiproliferative activities against four tumor cell lines of MCF-7, HT-29, HuH-7, and LNCap. Compounds 2 and 5 inhibited HT-29 cells in a good dose-dependent manner. Mechanism investigation uncovered that they could significantly induce cell cycle G2-M phase arresting by increasing the protein levels of p-H3 and cyclin B1.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Octadecylsilane, 97%
Sigma-Aldrich
4′,6-Diamidino-2-phenylindole dihydrochloride, powder, BioReagent, suitable for cell culture, ≥98% (HPLC and TLC), suitable for fluorescence