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  • Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.

Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.

Proceedings of the National Academy of Sciences of the United States of America (2009-07-01)
Caroline E von Allmen, Nicole Schmitz, Monika Bauer, Heather J Hinton, Michael O Kurrer, Regula B Buser, Myriam Gwerder, Simone Muntwiler, Tim Sparwasser, Roger R Beerli, Martin F Bachmann
ABSTRACT

Suppression by natural CD4(+)CD25(+) regulatory T cells (Tregs) is one mechanism by which tolerance is maintained. However, the way in which Tregs mediate suppression is not well understood. Here, we show that secreted phospholipase A2 (sPLA2)-IID is selectively produced by Tregs. sPLA2-IID is a potent mediator of Treg function, because it strongly suppressed proliferation of CD4(+) and CD8(+) T cells in vitro and in vivo in a manner independent of its catalytic activity. Furthermore, sPLA2-IID promoted the differentiation of Tregs, presumably via attenuating signaling through the PI3K/Akt/mammalian target of rapamycin pathway. Importantly, administration of a sPLA2-IID-Fc fusion protein inhibited disease development in murine models of colitis and multiple sclerosis, suggesting that sPLA2-IID's immunosuppressive function might be exploited therapeutically.

MATERIALS
Product Number
Brand
Product Description

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