Copper-catalyzed synthesis of quinoxalines with o-phenylenediamine and terminal alkyne in the presence of bases.

Organic letters (2011-08-03)
Wen Wang, Yongwen Shen, Xu Meng, Mingming Zhao, Yongxin Chen, Baohua Chen
RESUMEN

A novel way of synthesizing quinoxalines efficiently through cyclization of o-phenylenediamine and terminal alkyne by Cu(II) and bases is developed. This reaction proceeds smoothly to give the products in moderate to good yields.

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Sigma-Aldrich
o-Phenylenediamine, flaked, 99.5%
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o-Phenylenediamine, Peroxidase substrate, ≥98.0%, powder
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o-Phenylenediamine, tablet, 20 mg substrate per tablet
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