Merck

Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.

Bioorganic & medicinal chemistry letters (2011-08-26)
Rohidas S Sulake, Chinpiao Chen, Huei-Ru Lin, Ahai-Chang Lua
PMID21865041
RESUMEN

A convenient synthesis of ketamine metabolite dehydronorketamine-d(4), starting from commercially available deuterium labeled bromochlorobenzene, was achieved. Key steps include Grignard reaction, regioselective hydroxybromination, Staudinger reduction, and dehydrohalogenation.

MATERIALES
Referencia del producto
Marca
Descripción del producto
23570
Sigma-Aldrich
Chlorobenzene, puriss. p.a., ACS reagent, ≥99.5% (GC)
319996
Sigma-Aldrich
Chlorobenzene, ACS reagent, ≥99.5%
40006
Supelco
Chlorobenzene solution, certified reference material, 5000 μg/mL in methanol
284513
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Chlorobenzene, anhydrous, 99.8%
08650
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270644
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101389
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Chlorobenzene, ReagentPlus®, 99%