Merck

Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.

Bioorganic & medicinal chemistry letters (2011-08-26)
Rohidas S Sulake, Chinpiao Chen, Huei-Ru Lin, Ahai-Chang Lua
RESUMEN

A convenient synthesis of ketamine metabolite dehydronorketamine-d(4), starting from commercially available deuterium labeled bromochlorobenzene, was achieved. Key steps include Grignard reaction, regioselective hydroxybromination, Staudinger reduction, and dehydrohalogenation.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Chlorobenzene, puriss. p.a., ACS reagent, ≥99.5% (GC)
Sigma-Aldrich
Chlorobenzene, ACS reagent, ≥99.5%
Supelco
Chlorobenzene solution, certified reference material, 5000 μg/mL in methanol
Sigma-Aldrich
Chlorobenzene, anhydrous, 99.8%
Supelco
Chlorobenzene, analytical standard
Sigma-Aldrich
Chlorobenzene, suitable for HPLC, 99.9%
Sigma-Aldrich
Chlorobenzene, ReagentPlus®, 99%