Induction of skin sensitization is augmented in Nrf2-deficient mice.

Archives of toxicology (2012-11-13)
Jochem W van der Veen, Eric R Gremmer, Jolanda P Vermeulen, Henk van Loveren, Janine Ezendam

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

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1-Chloro-2,4-dinitrobenzene, ≥99%
1-Chloro-2,4-dinitrobenzene, 97%