Merck

A new approach for diffusive sampling based on SPME for occupational exposure assessment.

Journal of occupational and environmental hygiene (2013-01-30)
P Marín, J F Periago, C Prado
RESUMEN

Passive sampling is a well-established methodology for the evaluation of exposures to environmental volatile organic compounds (VOCs). The solid-phase microextraction (SPME) technique is a reliable means of sampling VOCs in air. SPME is also being applied as a passive sampler to determine time-weighted average exposure. The use of SPME as a diffusive sampler was evaluated. The passive sampler is based on the use of a cylindrical diffusion cell (porous hydrophobic polyethylene) with an 80 μm carboxen/polydimethylsiloxane fiber to obtain radial diffusion of the analytes to the sorbent. Standard atmospheres of organic vapors in air were used to determine the experimental uptake rates for toluene and chlorobenzene. Toluene concentrations between 2 and 38 mg/m(3) with sampling times between 15 and 60 min were evaluated, as well as chlorobenzene concentrations between 2 and 47 mg/m(3) with sampling times between 30 and 60 min. The mean diffusive uptake rate was 2.14 mL/min for toluene and 2.57 mL/min for chlorobenzene, and no statistical significant effects of concentration and sampling time were observed under the studied conditions for the two compounds. Relative standard deviation ranged from 2.6 to 6.5%. The performance of the sampler under varying concentrations of toluene was also tested, showing that the sampler reflects the average exposure concentration. Effects of temperature, relative humidity, velocity of the air, back diffusion, competitive adsorption, and the stability of chlorobenzene in the sampler were also studied. Sampler behavior was tested in gas stations, and the results were successfully compared with a 3M-3500 diffusive sampler. The results are promising for using this new SPME device for diffusive monitoring for occupational exposure assessment.

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SPME fiber assembly Divinylbenzene/Carboxen/Polydimethylsiloxane (DVB/CAR/PDMS), for use with autosampler, needle size 23 ga, metal alloy fiber, fiber L 1 cm
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SPME fiber assembly Divinylbenzene/Carboxen/Polydimethylsiloxane (DVB/CAR/PDMS), for use with autosampler, needle size 23 ga, metal alloy fiber, fiber L 2 cm
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 85 μm (CAR/PDMS), for use with autosampler, needle size 23 ga, metal alloy fiber
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SPME fiber assembly Divinylbenzene/Carboxen/Polydimethylsiloxane (DVB/CAR/PDMS), needle size 23 ga, StableFlex, for use with manual holder/autosampler, fiber L 2 cm
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SPME fiber assembly Divinylbenzene/Carboxen/Polydimethylsiloxane (DVB/CAR/PDMS), needle size 23 ga, StableFlex, for use with autosampler
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 85 μm (CAR/PDMS), needle size 23 ga, StableFlex, for use with autosampler
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SPME fiber assembly Divinylbenzene/Carboxen/Polydimethylsiloxane (DVB/CAR/PDMS), needle size 24 ga, StableFlex, for use with manual holder/autosampler
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 75 μm (CAR/PDMS), needle size 24 ga, for use with autosampler
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Carboxen® Adsorbent, matrix Carboxen® 1000, 60-80 mesh, bottle of 10 g
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 75 μm (CAR/PDMS), needle size 23 ga, for use with manual holder
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 75 μm (CAR/PDMS), needle size 23 ga, for use with autosampler
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 75 μm (CAR/PDMS), for use with manual holder, needle size 24 ga
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 85 μm (CAR/PDMS), needle size 24 ga, for use with manual holder, StableFlex fiber
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SPME fiber assembly Carboxen/Polydimethylsiloxane (CAR/PDMS), df 85 μm (CAR/PDMS), needle size 24 ga, StableFlex, for use with autosampler
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SPME fiber assembly Divinylbenzene/Carboxen/Polydimethylsiloxane (DVB/CAR/PDMS), needle size 24 ga, for use with manual holder
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Carboxen® Adsorbent, matrix Carboxen® 564, 20-45 mesh, bottle of 10 g
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Carboxen® Adsorbent, matrix Carboxen® 1003, 40-60 mesh, bottle of 10 g
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Sigma-Aldrich
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Carboxen®-1010 PLOT Capillary GC Column, L × I.D. 30 m × 0.53 mm, average thickness 30 μm
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Chlorobenzene, analytical standard