Merck

[The effect of nitrates on the outcome of acute experimental ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2013-02-08)
V S Kuzenkov, A L Krushinskiĭ, V P Reutov
RESUMEN

Effects of nitrates NaNO(3), KNO(3), Mg(NO(3)) 2 on animals (Wistar rats) were studied on the basis of the experimental model of ischemic stroke induced by the occlusion of two carotid arteries. The animals were divided into two groups: the main group (n=60) and the control group (n=30). Three series of experiments were conducted. In each experiment, the rats of the main group were treated with one of nitrates and the control group was treated with physiological solution. It has been shown that nitrates exert either positive or negative effect depending on the cation type, nitrate concentration and the duration of their action on the dynamics of neurologic disturbances. Conditions of the development of neuroprotective effect of nitrates are discussed.

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