Merck

[The use of hydroxamic acids and sodium nitrate to enhance the antitumor effect of cyclophosphamide].

Voprosy onkologii (2013-07-03)
T N Bogatyrenko, Z V Kuropteva, T E Sashenkova, L M Baĭder, N P Konovalova
RESUMEN

It has been showed that the introduction of nitrocompounds (as nitic oxide donors) in to the compositions of cyclophosphamide and hydroxamic acids for curing animals having leukemia P-388 increased duration of life by 290%. Thereby 40% of animals have recovered. The therapeutic dose cyclophosphamide have been reduced by 6 times.

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