Merck

Hydrogen sulfide in hemostasis: friend or foe?

Chemico-biological interactions (2014-04-22)
Beata Olas
RESUMEN

Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Hydrogen sulfide, like carbon monoxide (CO) or nitric oxide (NO) is a signaling molecule in different biological systems, including the cardiovascular system. Moreover, hydrogen sulfide plays a role in the pathogenesis of various cardiovascular diseases. It modulates different elements of hemostasis (activation of blood platelet, and coagulation process) as well as proliferation and apoptosis of vascular smooth muscle cells. However, the biological role and the therapeutic potential of H2S is not clear. This review summarizes the different functions of hydrogen sulfide in hemostasis.

MATERIALES
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Sigma-Aldrich
L-Homocysteine, ≥98.0% (NT)
Sigma-Aldrich
Hydrogen sulfide, ≥99.5%
Sigma-Aldrich
Hydrogen sulfide, purum, ≥99.0%
Sigma-Aldrich
L-Cysteine, from non-animal source, BioReagent, suitable for cell culture, ≥98%
Sigma-Aldrich
L-Cysteine, 97%
Sigma-Aldrich
L-Cysteine, ≥97%, FG
SAFC
L-Cysteine
Sigma-Aldrich
L-Cysteine, BioUltra, ≥98.5% (RT)
Supelco
L-Cysteine, certified reference material, TraceCERT®
Sigma-Aldrich
Hydrogen sulfide solution, 0.8 M in THF
Sigma-Aldrich
L-Cysteine, produced by Wacker Chemie AG, Burghausen, Germany, ≥98.0%