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Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic.

Current topics in medicinal chemistry (2006-08-22)
Terrence R Burke
ABSTRACT

Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes. Among pTyr mimetics reported to date, phosphono(diflouromethyl)phenylalanine (F(2)Pmp) has shown particular utility when dealing with protein-tyrosine phosphatases (PTPs). The current overview presents the development of F(2)Pmp and a summary of approaches toward its synthesis and use.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-Phenylalanine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
L-Phenylalanine, reagent grade, ≥98%
Sigma-Aldrich
L-Phenylalanine, BioUltra, ≥99.0% (NT)
Supelco
L-Phenylalanine, certified reference material, TraceCERT®
Sigma-Aldrich
L-Phenylalanine, 99%, FCC
Supelco
L-Phenylalanine, analytical standard, for Nitrogen Determination According to Kjeldahl Method
Supelco
L-Phenylalanine, Pharmaceutical Secondary Standard; Certified Reference Material
USP
L-Phenylalanine, United States Pharmacopeia (USP) Reference Standard
Phenylalanine, European Pharmacopoeia (EP) Reference Standard