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- Nickel-catalyzed intramolecular [3 + 2 + 2] cycloadditions of alkylidenecyclopropanes. A straightforward entry to fused 6,7,5-tricyclic systems.
Nickel-catalyzed intramolecular [3 + 2 + 2] cycloadditions of alkylidenecyclopropanes. A straightforward entry to fused 6,7,5-tricyclic systems.
Organic letters (2014-09-19)
Lucía Saya, Israel Fernández, Fernando López, José L Mascareñas
PMID25232684
ABSTRACT
A highly diastereo- and chemoselective intramolecular nickel-catalyzed cycloaddition of alkene- and alkyne-tethered alkynylidenecyclopropanes is reported. The method constitutes the first fully intramolecular [3 + 2 + 2] alkylidenecyclopropropane cycloaddition occurring via a proximal cleavage of the cyclopropane and makes it possible to build relevant 6,7,5-tricyclic frameworks in a single-pot reaction. Importantly, the reaction outcome is highly dependent on the characteristics of the nickel ligands.
MATERIALS
Product Number
Brand
Product Description
Nickel, tube, 100mm, outside diameter 3.6mm, inside diameter 3.5mm, wall thickness 0.05mm, hard, 99.5%
Nickel, sphere, 500pcs, diameter 3.0mm, precision sphere grade 200, 99%
Nickel, rod, 200mm, diameter 16mm, 99.99+%
Nickel, foil, 15mm disks, thickness 0.0025mm, 99.95%
Nickel, foil, 15mm disks, thickness 0.0125mm, 99.9%
Nickel, foil, 15mm disks, thickness 0.015mm, 99.9%
Nickel, tube, 100mm, outside diameter 5.5mm, inside diameter 5mm, wall thickness 0.25mm, hard, 99.5%
Nickel, tube, 200mm, outside diameter 0.762mm, inside diameter 0.204mm, wall thickness 0.279mm, hard, 99.5%
Nickel, tube, 100mm, outside diameter 1.5mm, inside diameter 1.2mm, wall thickness 0.15mm, hard, 99.5%
Nickel, foil, 1m coil, thickness 0.015mm, 99.9%
Nickel, foil, 1m coil, thickness 0.125mm, coil width 50mm, annealed, 99%
Nickel, tube, 1000mm, outside diameter 0.78mm, inside diameter 0.2mm, wall thickness 0.29mm, as drawn, 99.5%
Nickel, tube, 1000mm, outside diameter 0.35mm, inside diameter 0.3mm, wall thickness 0.025mm, hard, 99.5%
Nickel, rod, 50mm, diameter 3.3mm, 99.99+%
Nickel, tube, 1000mm, outside diameter 5.5mm, inside diameter 5mm, wall thickness 0.25mm, hard, 99.5%
Nickel, tube, 100mm, outside diameter 7.11mm, inside diameter 6.57mm, wall thickness 0.27mm, hard, 99.5%
Nickel, foil, 1m coil, thickness 0.20mm, coil width 1mm, annealed, 99%
Nickel, tube, 1000mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, hard, 99.5%
Nickel, foil, 1m coil, thickness 0.004mm, hard, 99.98%
Nickel, foil, 1m coil, thickness 0.0125mm, annealed, 99%
Nickel, tube, 200mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, hard, 99.5%
Nickel, foil, 15mm disks, thickness 0.003mm, 99.95%
Nickel, tube, 100mm, outside diameter 0.762mm, inside diameter 0.204mm, wall thickness 0.279mm, hard, 99.5%
Nickel, tube, 1000mm, outside diameter 0.8mm, inside diameter 0.5mm, wall thickness 0.15mm, as drawn, 99.5%
Nickel, foil, 15mm disks, thickness 0.05mm, annealed, 99.98%
Nickel, foil, 1m coil, thickness 0.0025mm, 99.95%
Nickel, foil, 15mm disks, thickness 0.02mm, 99.9%
Nickel, tube, 100mm, outside diameter 2.0mm, inside diameter 1.8mm, wall thickness 0.1mm, hard, 99.5%
Nickel, foil, 15mm disks, thickness 0.25mm, annealed, 99%
Nickel, tube, 1000mm, outside diameter 2.5mm, inside diameter 2mm, wall thickness 0.25mm, hard, 99.5%