Access to large cyclic peptides by a one-pot two-peptide segment ligation/cyclization process.

Organic letters (2014-12-17)
Emmanuelle Boll, Jean-Philippe Ebran, Hervé Drobecq, Ouafâa El-Mahdi, Laurent Raibaut, Nathalie Ollivier, Oleg Melnyk
RESUMEN

The use of the N-acetoacetyl protecting group for N-terminal cysteine residue enabled creation of an efficient and mild one-pot native chemical ligation/SEA ligation sequence giving access to large cyclic peptides.

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