Development and characterization of stable nanovesicular carrier for drug delivery.

Artificial cells, nanomedicine, and biotechnology (2013-07-20)
Praveen Kumar Gaur, Suresh Purohit, Yatendra Kumar, Shikha Mishra, Anil Bhandari

Lipid vesicles are an important drug carrier which can serve for controlled delivery of drugs; however, these vesicles are quite unstable at ambient temperature and require stringent storage condition. Present work was done to develop a stable vesicular system for drug delivery. Vesicles of ceramide-2, cholesterol, cholesterol sulfate, and palmitic acid were prepared and compared with phosphatidylcholine vesicles for physicochemical parameters and accelerated stability. Diclofenac sodium was used as a model drug. Based on physicochemical parameter and in vitro release PCV-3 and CV-3 were selected for further studies in three different accelerated stability conditions. PCV-3 showed moderate changes at 4°C but was severely affected at 25°C and 40°C. CV-3 showed stable characteristics at 4°C and 25°C whereas at 40°C, CV-3 showed signs of slight modification owing to moisture absorption. Based on the study, CV-3 containing highest content of palmitic acid was found to be most stable.

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Palmitic acid, ≥99%
Palmitic acid, BioXtra, ≥99%
Palmitic acid, analytical standard
Palmitic acid, Pharmaceutical Secondary Standard; Certified Reference Material
Palmitic acid, ≥95%, FCC, FG
Palmitic acid, natural, 98%, FG
Palmitic acid, United States Pharmacopeia (USP) Reference Standard
Palmitic acid, ≥98% palmitic acid basis (GC)
Palmitic acid, European Pharmacopoeia (EP) Reference Standard
Palmitic acid, certified reference material, TraceCERT®