New cholinesterase inhibitors from Garcinia atroviridis.

Fitoterapia (2014-06-14)
Wen-Nee Tan, Melati Khairuddean, Keng-Chong Wong, Kooi-Yeong Khaw, Murugaiyah Vikneswaran
RESUMEN

A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge.

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