Some new cadmium(II) Schiff base complexes CdLX2 (where X=Cl(-), Br(-), I(-), SCN(-) and N3(-) and L=N,N-bis((E)-3-(4-(dimethylamino)phenyl)allylidene)benzene-1,2-diamine) were synthesized and characterized by elemental analysis, FT-IR, UV-visible, (1)HNMR spectra, and conductivity measurements. Moreover, the structure of the CdLI2 was determined by single crystal X-ray crystallography. CdLI2 crystallizes in a triclinic system with space group P 1̅. The molecular structure shows distorted tetrahedral coordination geometry. The CH....π and π-π stacking interactions connect the molecules to a supramolecular network. The thermal properties of the compounds were investigated from the room temperature to 800 °C with a heating rate of 10 °C/min and decomposition activation parameters were evaluated from the TG/DTG plots. Antibacterial/antifungal activities of the compounds were screened by the disk diffusion method against the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and the fungi strain Aspergillus niger and Candida albicans. The antimicrobial activities were determined for all compounds and the complexation was found to enhance the inhibitory activity. Finally, the DNA cleavage potential of the compounds was investigated by agarose gel electrophoresis method.