Metabolic Imaging with ISOTEC® Stable Isotopes

Compounds labeled with stable isotopes are used in magnetic resonance imaging to render visible metabolic changes in the body. The goal of this application is the early diagnosis and treatment of neuropsychiatric disorders, cancer, and other disease states.

The use of stable isotopes in MRI/MRS imaging has advanced exponentially. Researchers are using stable isotopes for advanced technologies such as hyperpolarization for in vivo MRI imaging to create metabolic profiles to map and study alterations due to diseases. Dynamic Nuclear Polarization (DNP) and Para Hydrogen Induced Polarization (PHIP) are two hyperpolarization techniques currently used in MRI. Each technique has advantages that researchers are exploring for potential use in clinical applications. Stable isotopes, in conjunction with 13C-MRS in vivo techniques, provide a way to explore fluxes through energy-related metabolic pathways. Various 13C labeled glucose, pyruvate and lactate compounds elucidate tricarboxylic acid (TCA) cycle turnover and glutamate and glutamine metabolism. As such, 13C-MRS studies involve understanding metabolism at the molecular level.

We offer a wide variety of isotopically-labeled compounds for all MRI / MRS applications, including hyperpolarization. Our S&E tested products and full GMP certified material adhere to the most rigorous standards in the industry to meet customer specifications.