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141101P

Avanti

Brain Extract Polar

Avanti Polar Lipids

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Synonym(s):
Brain Polar Lipid Extract (Porcine)
CAS Number:
86088-88-2
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 100 mg (141101P-100mg)
pkg of 5 × 100 mg (141101P-500mg)

manufacturer/tradename

Avanti Polar Lipids

lipid type

lipid extracts

shipped in

dry ice

storage temp.

−20°C

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Brain Extract Polar Avanti Polar Lipids

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Heart Extract Polar Avanti Polar Lipids

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Heart Extract Polar

Heart Extract Polar Avanti Polar Lipids

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packaging

pkg of 1 × 100 mg (141101P-100mg), pkg of 5 × 100 mg (141101P-500mg)

packaging

pkg of 1 × 4 mL (141101C-100mg), pkg of 5 × 4 mL (141101C-500mg)

packaging

pkg of 1 × 4 mL (171204C-100mg)

packaging

pkg of 1 × 100 mg (171204P-100mg)

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids 171204C

manufacturer/tradename

Avanti Polar Lipids 171204P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Brain Extract Polar comprises phosphatidylethanolamine as a major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.

Application

Brain Extract Polar has been used in parallel artificial membrane permeability assay (PAMPA) for coating membrane to evaluate blood brain-barrier permeability, and for drug permeability studies.

Biochem/physiol Actions

Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes. Brain lipid, especially the polar fraction play a key role in the inhibition of prion seeded amyloid formation.

Packaging

5 mL Clear Glass Sealed Ampule (141101P-100mg)
5 mL Clear Glass Sealed Ampule (141101P-500mg)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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Liver Extract Total Avanti Polar Lipids

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Heart Extract Total Avanti Polar Lipids

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Heart Extract Total

Sigma-Aldrich

Sigma-Aldrich

B3635

Brain Extract from bovine brain

Sphingomyelin Quantification Colorimetric Assay Kit sufficient for 100 colorimetric tests

Sigma-Aldrich

MAK262

Sphingomyelin Quantification Colorimetric Assay Kit

E. coli Extract Polar Avanti Polar Lipids

Avanti

100600C

E. coli Extract Polar

Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition
Zhu J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 151, 42-48 (2018)
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Hallifax D, et al.
European Journal of Pharmaceutical Sciences, 45(5), 570-574 (2012)
Irene Paterniti et al.
PloS one, 6(1), e15937-e15937 (2011-02-08)
Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and
Laura Campello et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 142-159 (2020-02-07)
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords
Endogenous brain lipids inhibit prion amyloid formation in vitro
Hoover CE, et al.
Journal of Virology, 91(9), e02162-e02116 (2017)
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