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850725P

Avanti

18:1 (Δ9-Cis) PE (DOPE)

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, powder

Synonym(s):
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; DOPE; PE(18:1(9Z)/18:1(9Z)); 110635
Empirical Formula (Hill Notation):
C41H78NO8P
CAS Number:
Molecular Weight:
744.03
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850725P-1g)
pkg of 2 × 100 mg (850725P-200mg)
pkg of 5 × 100 mg (850725P-500mg)
pkg of 1 × 25 mg (850725P-25mg)

manufacturer/tradename

Avanti Polar Lipids 850725P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

General description

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.

Application

18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) forms a stable lipid layer and rapidly fuses with endosomal lipid bilayer. DOPE in combination with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) has high in vitro transfection efficiency.

Packaging

20 mL Clear Glass Screw Cap Vial (850725P-1g)
5 mL Clear Glass Sealed Ampule (850725P-200mg)
5 mL Clear Glass Sealed Ampule (850725P-25mg)
5 mL Clear Glass Sealed Ampule (850725P-500mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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