81172

Poly(ethylene glycol)

tested according to Ph. Eur., 400

• Synonym(s): Macrogol 400, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• PubChem Substance ID: 24887676
• NACRES: NA.21

Properties

• Agency: tested according to Ph. Eur.
• Quality Level: 200
• form: liquid
• mol wt: 380-420
• application(s): pharmaceutical (small molecule)
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Polyethylene glycol (PEG) is a polyether compound with repeated ethylene glycol units[-(CH₂CH₂O)_n].

Application

Poly(ethylene glycol) has been used as a liquid medium to prepare shear thickening fluid (STF) by directly mixing it with fumica silica.

Biochem/physiol Actions

Polyethylene glycol (PEG) is a synthetic polymer and is used as an additive in food, cosmetics, and pharmaceuticals. It is also involved in biomedical applications like biosensing, imaging, and tissue engineering. PEG is used as a gold standard in bioconjugation and nanomedicine thereby increasing blood circulation time and improving drug efficacy. PEG-conjugated drugs are approved by the U.S. Food and Drug Administration (FDA). They are considered safe for use in humans. PEG reduces the liver uptake and repels protein adsorption, which makes it useful in nanocoating.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves