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P4338

Sigma-Aldrich

Poly(ethylene glycol)

BioXtra, average mol wt 3,350, powder

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Synonym(s):
PEG
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.23

product line

BioXtra

Quality Level

form

powder

mol wt

average mol wt 3,350

impurities

≤0.01% Phosphorus (P)
≤0.1% Insoluble matter

solubility

water: soluble (PEG is soluble in water approximately 670 mg/ml, 20 °C)

density

1.0962 g/mL at 60 °C
1.0764 g/mL at 80 °C

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

Ω-end

hydroxyl

α-end

hydroxyl

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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Poly(ethylene glycol) BioXtra, average mol wt 3,350, powder

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Poly(ethylene glycol) Hybri-Max™, mol wt 3,000-3,700, waxy solid, BioReagent, suitable for hybridoma

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Poly(ethylene glycol)

Poly(ethylene glycol) Vetec™, reagent grade, avg mol wt 8,000

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Poly(ethylene glycol)

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

-

mol wt

average mol wt 3,350

mol wt

average mol wt 8,000

mol wt

3,000-3,700

mol wt

avg mol wt 8,000

α-end

hydroxyl

α-end

hydroxyl

α-end

-

α-end

-

Ω-end

hydroxyl

Ω-end

hydroxyl

Ω-end

-

Ω-end

-

impurities

≤0.01% Phosphorus (P), ≤0.1% Insoluble matter

impurities

-

impurities

endotoxin, tested

impurities

-

General description

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. PEG is a suitable material for biological applications because it does not trigger an immune response.

Application

Poly (ethylene glycol) (PEG) can be used to functionalize magnetic nanoparticles in combination with nonionic surfactant Tween 80. PEG functionalization improves the biocompatibility of magnetite nanoparticles. It also reduces the surface charge and maintains the magnetic characteristics of nanoparticles.

PEG can be used as an exterior coating for the pharmaceutical final dosage forms. This can avoid moisture from encountering active pharmaceutical ingredients. For example, Naproxen solid dispersions are coated with PEG by drop printing technique. The PEG layer protects the solid dispersions from moisture-accelerated crystallization and enhances their stability.

Nanostructured hydroxyapatite (HAP) can be prepared by a sol-gel technique using PEG as an organic modifier. The addition of PEG has an influence on the morphology of HAP particles. At high temperatures, more flexible PEG molecules result in the formation of large-sized HAP platelets. At low synthesis temperatures, less flexible PEG colloids form nanostructured HAP.

PEG powder can also be used as a laxative agent.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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