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L9650

Sigma-Aldrich

Lithium chloride

for molecular biology, ≥99%

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Synonym(s):
LiCl
Linear Formula:
LiCl
CAS Number:
Molecular Weight:
42.39
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.31

grade

for molecular biology

Quality Level

Assay

≥99%

form

powder

mp

605 °C (lit.)

solubility

H2O: 100 mg/mL at 20 °C, clear, colorless

anion traces

sulfate (SO42-): ≤0.01%

cation traces

Ba: ≤0.003%
Fe: ≤0.001%
K: ≤0.01%
Na: ≤0.20%
heavy metals (as Pb): ≤0.002%

foreign activity

DNase, NICKase, RNase, protease, none detected

SMILES string

[Li+].[Cl-]

InChI

1S/ClH.Li/h1H;/q;+1/p-1

InChI key

KWGKDLIKAYFUFQ-UHFFFAOYSA-M

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1 of 4

This Item
L4408213233793620
Lithium chloride for molecular biology, ≥99%

L9650

Lithium chloride

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Lithium chloride BioXtra, ≥99.0% (titration)

L4408

Lithium chloride

Premium Grade
Lithium chloride ReagentPlus®, 99%

213233

Lithium chloride

-
Lithium chloride anhydrous, free-flowing, Redi-Dri™, ReagentPlus®, 99%

793620

Lithium chloride

-
solubility

H2O: 100 mg/mL at 20 °C, clear, colorless

solubility

H2O: 1 M, clear, colorless

solubility

-

solubility

-

assay

≥99%

assay

≥99.0% (titration)

assay

99%

assay

99%

grade

for molecular biology

grade

-

grade

-

grade

anhydrous

anion traces

sulfate (SO42-): ≤0.01%

anion traces

sulfate (SO42-): ≤0.01%

anion traces

-

anion traces

-

mp

605 °C (lit.)

mp

605 °C (lit.)

mp

605 °C (lit.)

mp

605 °C (lit.)

Application

Lithium chloride has been used:
  • in the preparation of wash buffer for chromatin immunoprecipitation
  • in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
  • to treat aged myoblast as glycogen synthase kinase (GSK) inhibitor to analyse its effect on wingless/tailess (wnt) signaling

May be used to selectively pre­cipitate RNA.

Biochem/physiol Actions

Lithium chloride has the ability to block glycogen synthase kinase (GSK). It may also possess anti-inflammatory effects at low and non-toxic concentrations.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A laboratory practical illustrating the use of the ChIP-qPCR method in a robust model: Estrogen receptor alpha immunoprecipitation using Mcf-7 culture cells
Lacazette E
Biochemistry and Molecular Biology Education, 45(2), 152-160 (2017)
mTOR and neuroinflammation
Molecules to Medicine with mTOR, 317-329 (2016)
Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms
Liu R, et al.
Molecular and cellular biology, 28(23), 7236-7244 (2008)
Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts
Vertino AM, et al.
Molecular Biology of the Cell, 16(4), 2039-2048 (2005)
Alessandro Di Maio et al.
EvoDevo, 6, 17-17 (2015-07-15)
Wnt signaling is one of the earliest and most highly conserved regulatory pathways for the establishment of the body axes during regeneration and early development. In regeneration, body axes determination occurs independently of tissue rearrangement and early developmental cues. Modulation

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