Merck
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SML0801

Sigma-Aldrich

Palomid 529

≥98% (HPLC)

Synonym(s):
8-(1-Hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one, 8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one, P529, SG 00529
Empirical Formula (Hill Notation):
C24H22O6
CAS Number:
Molecular Weight:
406.43
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

InChI

1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3

InChI key

YEAHTLOYHVWAKW-UHFFFAOYSA-N

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Palomid 529

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SML1335

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

room temp

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Biochem/physiol Actions

Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor, which is unique in that it causes the dissociation of both the TORC1 and TORC2 complexes and inhibits both Akt and mTOR signaling. Palomid 529 has been shown to inhibit tumor growth, angiogenesis, and vascular permeability. Palomid 529 (P529) inhibited glioblastoma growth, penetrating the blood brain barrier with little affinity for ATP-binding cassette (ABC) drug efflux transporters ABCB1 and ABCG2. Palomid 529 has also shown promise as a possible treatment for macular degeneration and keloid disease.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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