Merck
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SML2897

Sigma-Aldrich

Flomoxef Sodium

≥97% (HPLC)

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Synonym(s):
(6R,7R)-7-[[2-[(Difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt, 6315-S Sodium salt, FMOX Sodium salt
Empirical Formula (Hill Notation):
C15H17F2N6O7S2 · Na
CAS Number:
92823-03-5
Molecular Weight:
518.45

Quality Level

100

Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

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Flomoxef Sodium

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Cefotiam dihydrochloride hydrate

Cefapirin sodium analytical standard

Supelco

43989

Cefapirin sodium

Ceftibuten hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0037

Ceftibuten hydrate

form

powder

form

powder

form

-

form

powder

color

white to beige

color

white to tan

color

-

color

white to beige

solubility

H2O: 2 mg/mL, clear

solubility

H2O: ≥22 M

solubility

-

solubility

DMSO: ≥50 mg/mL

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

Biochem/physiol Actions

Flomoxef is a semisynthetic oxacephem antibiotic. Flomoxef exhibit activity against epidermides, streptococci, propionibacteria, and both methicillin-resistant and -susceptible Staphylococcus aureus. Flomoxef appear to be stable to the common plasmid beta-lactamases TEM and SH4V-1 or by the betalactamases of S. aureus or B. fragilis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Chen-Hsiang Lee et al.
Infection and drug resistance, 11, 2471-2480 (2018-12-21)
Flomoxef is potentially effective against β-lactamase-producing Enterobacteriaceae because limited clinical data demonstrate its effectiveness against Enterobacteriaceae bloodstream infections (BSIs) based on its minimum inhibitory concentrations (MICs). This study was conducted to determine the optimal breakpoints based on the survival of
H C Neu et al.
Antimicrobial agents and chemotherapy, 30(5), 638-644 (1986-11-01)
6315-S, a novel difluoromethyl thioacetamido oxacephem, had in vitro activity comparable to that of cefotaxime and moxalactam against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Klebsiella oxytoca, Citrobacter diversus, Salmonella spp., and Shigella spp., inhibiting 90% at less than or equal
Jen-Jia Yang et al.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 51(5), 681-687 (2017-07-12)
Suppression of intestinal flora by broad-spectrum antimicrobial agents facilitated risk of colonization or infection with resistant pathogen. We aimed to investigate the changes in bowel carriage of target resistant microorganisms (TRO) among patients treated with three different classes of Pseudomonas-sparing

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