Merck
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SML3498

Sigma-Aldrich

L6H21

≥98% (HPLC)

All Photos(1)
Synonym(s):
(2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one, (E)-2,3,4′-Trimethoxy-chalcone, (E)-2,3-Dimethoxy-4′-methoxychalcone, L 6H21
Empirical Formula (Hill Notation):
C18H18O4
CAS Number:
24533-47-9
Molecular Weight:
298.33
MDL number:
MFCD01901426

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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This Item
SMB00388SML2798SML3678
L6H21 ≥98% (HPLC)

Sigma-Aldrich

SML3498

L6H21

2,4,3′,5′-tetramethoxystilbene ≥98% (HPLC)

Sigma-Aldrich

SMB00388

2,4,3′,5′-tetramethoxystilbene

Sigma-Aldrich

Sigma-Aldrich

SML2798

CH625

ML-SI3 ≥98% (HPLC)

Sigma-Aldrich

SML3678

ML-SI3

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to yellow

color

white to beige

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

Biochem/physiol Actions

L6H21 is an orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist and shows a great inhibitory effect on pro-inflammatory cytokines expression levels. L6H21 binds to the hydrophobic pocket of MD2 in a dose-dependent manner with a high affinity (Kd = 33.3 µM) and inhibits the ability of LPS to recognize TLR4/MD2 complex. Suppresses NLRP3 inflammasome activation and may serve as a potential candidate for the treatment of allograft rejection.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H400

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Huaicheng Chen et al.
Experimental & molecular medicine, 53(4), 681-694 (2021-04-21)
Modified LDL-induced inflammation and oxidative stress are involved in the pathogenesis of diabetic retinopathy. Recent studies have also shown that modified LDL activates Toll-like receptor 4 (TLR4) to mediate retinal injury. However, the mechanism by which modified LDL activates TLR4
Yi Zhang et al.
Molecules (Basel, Switzerland), 25(1) (2019-12-22)
Angiotensin II (Ang II) participates in the pathogenesis of liver injury. Our previous publications reported that myeloid differentiation protein 2 (MD2) mediates Ang II-induced cardiac and kidney inflammation by directly binding to Ang II. Thus, we hypothesize that MD2 is
Thura Tun Oo et al.
British journal of pharmacology, 179(6), 1220-1236 (2021-11-20)
Chronic high-fat diet (HFD) intake instigates prediabetes and brain pathologies, which include cognitive decline and neuroinflammation. The myeloid differentiation factor 2 (MD-2)/toll-like receptor 4 (TLR4) complex plays a pivotal role in neuroinflammation. The MD-2 inhibitor (L6H21) reduces systemic inflammation and

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