High-Quality Granulated Raw Materials

Granulated materials are particularly beneficial when powder materials tend to cake during storage, exhibit poor flow properties, and stick together. Especially when large volumes of material are stored for longer timeframes, caking and clumping can present a significant issue for processability and operator safety. We have identified several key materials where pharma and biopharma manufacturers of liquid dosages benefit most from granulation: ammonium sulfate, glycine, potassium chloride, sodium acetate trihydrate, sodium chloride, sodium dihydrogen phosphate dihydrate, di-sodium hydrogen phosphate heptahydrate, and urea—all of which demonstrate superior performance compared to their ungranulated counterparts. As we continually seek to enhance our offerings, the portfolio of granulated materials may expand in the future.

Compared to standard bulk powder material, granulated products offer improved flowability and reduced tendency to cake or clump, which leads to better handling and increased operator safety. In contrast, caked material can be extremely challenging to weigh or feed into the process, as blocks must first be broken apart. This not only frequently causes time delays but can also result in operator injury. While managing caked material may be more feasible during small-scale development (though still inconvenient), it can lead to process disruptions in large-scale production. Additionally, granulated materials produce less dust, further improving operator safety. Watch our webinar “Addressing Raw Material Handling Challenges by Dry Granulation” to learn more about risks of caking.

From a chemical perspective, the powder material and our granulated material are identical, as no additives are added during the dry powder compaction process, which is gentle and does not involve high temperatures. However, physical properties of the granulated material differ from the original powder form; granulated material demonstrates increased particle size and improved flowability.

Key benefits of granulated raw materials include their significantly reduced caking behavior, improved handling and processability, and increased operator safety due to less dust formation and eliminating the need to manually break apart caked blocks. This results in a smoother process flow and helps avoid time delays and process disruption.

Additionally, all our Emprove^® chemicals come with comprehensive technical, regulatory and supply documentation to facilitate risk assessment and regulatory filing. Our Emprove^® Expert products feature specified low endotoxin and microbial levels, making them ideal for high-risk applications.