Merck
All Photos(1)

332615

Sigma-Aldrich

Methyl-β-cyclodextrin

average Mn 1310

Synonym(s):
MβCD, MEBCD, Methyl-β-CD, Methyl-beta-cyclodextrin
CAS Number:
NACRES:
NA.22

form

powder

Quality Level

optical activity

[α]25/D +159°, c = 1 in H2O

mol wt

average Mn 1310

extent of labeling

1.6-2.0 mol CH3 per unit anhydroglucose

mp

180-182 °C (lit.)

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3

InChI key

QGKBSGBYSPTPKJ-UHFFFAOYSA-N

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This Item
PHR1439239760C4767
Beta-Cyclodextrin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1439

Beta-Cyclodextrin

β-Cyclodextrin Homogeneous cyclic α1,4-linked D-glucopyranose units in a seven-member ring. Forms clathrates. Suitable for use with dansyl chloride to form water-soluble complexes for fluorescent labeling of proteins.

Millipore

239760

β-Cyclodextrin

β-Cyclodextrin ≥97%

Sigma-Aldrich

C4767

β-Cyclodextrin

form

powder

form

powder

form

solid

form

powder

mp

180-182 °C (lit.)

mp

290-300 °C (dec.) (lit.)

mp

-

mp

290-300 °C (dec.) (lit.)

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

200

optical activity

[α]25/D +159°, c = 1 in H2O

optical activity

[α]20/D +162±3°, c = 1.5% in H2O

optical activity

-

optical activity

[α]20/D +162±3°, c = 1.5% in H2O

mol wt

average Mn 1310

mol wt

-

mol wt

-

mol wt

-

extent of labeling

1.6-2.0 mol CH3 per unit anhydroglucose

extent of labeling

-

extent of labeling

-

extent of labeling

-

General description

Methyl-β-cyclodextrin (MβCD) is a macrocyclic compound that can form inclusion complexes with a number of guest molecules. It shows higher solubility in aqueous solutions and greater solubilizing and complexing power compared to the parent β-cyclodextrin. MβCD can be used to enhance the enzyme activity and enantioselectivity of subtilizing enzyme in organic solvents.

Application

Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
Methyl-β-cyclodextrin may be used as:
  • A buffer additive for the effective separation of aminophospholipids by modified micellar electrokinetic capillary chromatography (MEKC) coupled with laser-induced fluorescence detection.
  • A mobile phase additive for the analysis of R,S-naproxen mixtures in commercial tablet formulations by conventional and nano-liquid chromatography (nano-LC).
  • An analytical standard for the determination of the analyte in biological samples by high performance liquid chromatography (HPLC).
  • A chiral selector for the resolution of repaglinide enantiomers in pharmaceutical formulations by capillary electrophoresis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

368.6 °F

Flash Point(C)

187 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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