779776

Methyl-β-cyclodextrin

Wacker Chemie AG, ≥95.0% cyclodextrin basis (calculated)

• Synonym(s): Cavasol^® W7 M, Methyl-beta-cyclodextrin
• CAS Number: 128446-36-6
• MDL number: MFCD00066764
• UNSPSC Code: 12352201
• NACRES: NA.22

Properties

• Assay: ≥95.0% cyclodextrin basis (calculated)
• form: powder
• manufacturer/tradename: Wacker Chemie AG
• extent of labeling: 1.6-1.9 molar substitution
• impurities: ≤0.2% unsubstituted cyclodextrin; ≤0.2% volatile organics; ≤2% chloride
• loss: ≤7.0% loss on drying
• mp: 180-182 °C (lit.)
• SMILES string: O1C2OC(C(OC3OC(C(OC4OC(C(OC5OC(C(OC6OC(C(OC7OC(C(OC8OC(C1C(C8OC)O)COC)C(C7OC)O)COC)C(C6OC)O)COC)C(C5OC)O)COC)C(C4OC)O)COC)C(C3OC)O)COC)C(C2OC)O)COC
• InChI: 1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3
• InChI key: QGKBSGBYSPTPKJ-UHFFFAOYSA-N

Description

Application

Methyl-β-cyclodextrin (M-β-CD) can be used as a reactant to prepare ternary inclusion complex of diclofenac (DCF) in the presence of monoethanolamine (MEA). This complex improves the percutaneous absorption of DCF in human skin.[1] It can also be used to form an inclusion complex with olanzapine (OLP) to increase its solubility for efficient drug delivery.[2]

Other Notes

For R&D Use

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): 368.6 °F
• Flash Point(C): 187 °C