Merck
All Photos(1)

1.03893

SAFC

Benzenesulfonic acid

EMPROVE® EXPERT

Synonym(s):
Benzene sulphonic acid, Benzenesulphonic acid, Besylic acid, Phenylsulfonic acid, Phenylsulphonic acid
Linear Formula:
C6H5SO3H
CAS Number:
Molecular Weight:
158.18
Beilstein:
742513
EC Number:
MDL number:

Quality Level

biological source

synthetic

product line

EMPROVE® EXPERT

form

crystalline

impurities

endotoxins, low

application(s)

liquid formulation
parenterals
pharmaceutical

SMILES string

OS(=O)(=O)c1ccccc1

InChI

1S/C6H6O3S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H,7,8,9)

InChI key

SRSXLGNVWSONIS-UHFFFAOYSA-N

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General description

For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. Benzenesulfonic Acid Emprove® Expert is part of this new proprietary technology platform.

Packaging

1038930500 / 500g / Glass bottle
1038931000 / 1kg / Glass bottle

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Certificate of Analysis

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Certificate of Quality

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What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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Quality Management Dossier

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Operational Excellence Dossier

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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