1.06756

Methyl 4-hydroxybenzoate sodium salt

EMPROVE^® ESSENTIAL, Ph. Eur., BP, NF

• Synonym(s): Methyl 4-hydroxybenzoate sodium salt, 4-Hydroxybenzoic acid methyl ester sodium salt, Methylparaben sodium salt
• Linear Formula: Na⁺[4-(O)C₆H₄(COOCH₃)]^-
• CAS Number: 5026-62-0
• Molecular Weight: 174.13
• MDL number: MFCD00016470
• EC Index Number: 225-714-1

Properties

• Agency: BP; NF; Ph. Eur.
• Quality Level: 500
• product line: EMPROVE^® ESSENTIAL
• form: solid
• autoignition temp.: >600 °C
• pH: 9.7-10.3 (1 g/L in H₂O)
• mp: >125 °C
• density: 1.42 g/cm³ at 20 °C
• application(s): liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 15-25°C
• InChI: 1S/C8H8O3.Na/c1-11-8(10)6-2-4-7(9)5-3-6;/h2-5,9H,1H3;/q;+1/p-1
• InChI key: PESXGULMKCKJCC-UHFFFAOYSA-M

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard methyl 4-hydroxybenzoate.

Packaging

5 kg in PE bottle

20 kg in double PE bag (DPES in carton)

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H315 - H318 - H412
• Precautionary Statements: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1