1.06757

Methyl 4-hydroxybenzoate

EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, NF

• Synonym(s): Methyl 4-hydroxybenzoate, Methylparaben, 4-Hydroxybenzoic acid methyl ester
• Linear Formula: 4-(OH)C₆H₄(COOCH₃)
• CAS Number: 99-76-3
• Molecular Weight: 152.15
• MDL number: MFCD00002352
• EC Index Number: 202-785-7

Properties

• Agency: BP; JP; NF; Ph. Eur.
• Quality Level: 500
• vapor pressure: 0.000005 hPa ( 20 °C)
• product line: EMPROVE^® ESSENTIAL
• assay: 99.0-100.5% (HPLC); 99.0-102.0% (acidimetric)
• form: solid
• autoignition temp.: >600 °C
• technique(s): API processing | cocrystal formation: suitable
• pH: 5.8 (20 °C in H₂O, saturated solution)
• mp: 125 °C
• solubility: 1.88 g/L
• density: 1.38 g/cm³ at 20 °C
• application(s): liquid formulation; ophthalmics; parenterals; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 15-25°C
• InChI: 1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3
• InChI key: LXCFILQKKLGQFO-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate.

Packaging

25 g in Plastic bottle

5 kg in PE bag (in carton)

20 kg in double PE bag (DPES in carton)

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS09
• Hazard Statements: H411
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 334.4 °F
• Flash Point(C): 168 °C